Results 1 to 10 of about 3,736 (194)

Tumor‐Derived CDC37 Inhibits Antigen Cross‐Presentation in Dendritic Cells and Impairs Anti‐Tumor Immunity in Breast Cancer [PDF]

Advanced Science
Tumor mutational burden (TMB), usually representing high immunogenicity, cannot always predict treatment response of immune checkpoint blockade (ICB).
Ruxin Wang, Yunyi Zhang, Xiangyu Meng, Jianli Zhao, Yue Xing, Qian Ouyang, Ning Zhang, Huiping Chen, Nanyan Miao, Erwei Song, Di Huang   +10 more
doaj   +3 more sources

Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System

Cell Reports, 2017
Summary: Selective recruitment of protein kinases to the Hsp90 system is mediated by the adaptor co-chaperone Cdc37. We show that assembly of CDK4 and CDK6 into protein complexes is differentially regulated by the Cdc37-Hsp90 system.
Martyna W Pastok, Martin Noble, Laurence Pearl   +2 more
exaly   +5 more sources

Comparative analysis of the impact of Heat shock protein 90 kDa or Cdc37 mutation on the yeast proteome [PDF]

Cell Stress & Chaperones
Hsp90 is an abundant and essential molecular chaperone that is required for the folding and/or activity of up to 15%-20% of all yeast proteins. Hsp90 and its cochaperone Cdc37 are of interest due to their cooperative role in chaperoning oncogenic protein
Erick I. Rios, Jill L. Johnson
doaj   +2 more sources

Heat Shock Proteins in Cancer: Mechanisms and Therapeutic Targeting. [PDF]

MedComm (2020)
This review illustrates heat shock proteins (HSPs) as central regulators of cancer metabolic reprogramming. By stabilizing key metabolic enzymes and coordinating glycolysis, oxidative phosphorylation, redox homeostasis, and stress adaptation, HSPs support tumor growth, metastasis, and therapeutic resistance. Targeting HSP networks may therefore provide
Ma S, Liu CQ, Ma SY, Wang SG, Xia QD, Xu MY.   +5 more
europepmc   +2 more sources

Self-Assembled Dictamni Cortex Nanoparticles Ameliorate Psoriasis by Epigenetic Modulation of HSP90AB1 and Suppression of the Inflammatory Response. [PDF]

Adv Sci (Weinh)
This study develops self‐assembled Dictamni Cortex (BXP)‐Fe(III) infinite coordination polymer nanoparticles (NB) to improve BXP's solubility and bioavailability for psoriasis. NB transdermally treats psoriasis by targeting the epigenetic regulator CTCF (CCCTC‐binding factor), suppressing HSP90AB1 (heat shock protein 90 alpha family class B member 1 ...
Zhang Z, Du W, Zhang X, Cui H, Cheng B, Han X, He K, Yin T, Liu X, Xian N, Wang Z, Liu M, Han D, Liu J, Zheng Y, Wang Y.   +15 more
europepmc   +2 more sources

The oncolytic avian reovirus p17 protein triggers chaperone-mediated autophagy by modulating Hsp90 and the T-complex protein-1 ring complex chaperones and co-chaperones to activate the IKK/NF-κB signaling [PDF]

Journal of Virology
This study is the first to reveal that oncolytic avian reovirus (ARV) modulates the IKK/NF-κB signaling through the Hsp90-Cdc37, T-complex protein-1 ring complex (TRiC)/Hsc70, and TRiC-phosducin-like protein 1 (PhLP1) chaperone complexes, thereby ...
Wei‐Ru Huang, Jyun-Yi Li, Tsai-Ling Liao, Lon-Fye Lye, Muhammad Munir, Hung-Jen Liu   +5 more
doaj   +2 more sources

Koumine exerts its anti-colorectal cancer effects by disrupting the interaction between HSP90 and CDC37, thereby downregulating downstream signaling pathways [PDF]

Frontiers in Oncology
BackgroundKoumine, a principal bioactive alkaloid derived from the traditional Chinese herb Gelsemium elegans, has demonstrated broad cytotoxic activity against various cancer cell lines. However, its specific anti-tumor efficacy and underlying molecular
HaiLing Lin, YuXuan Bao, XiTong Cheng, ShuMing Zhang, DanYang Zhou, WanCai Que, WanCai Que   +6 more
doaj   +2 more sources

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies. [PDF]

Adv Sci (Weinh)
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Zhang B, Zou X, Zhou J, Sun Q, Chen D.
europepmc   +2 more sources

Molecular mechanism of PINK1 regulation by the Hsp90 machinery [PDF]

Nature Communications
Hundreds of human kinases, including PINK1—a protein kinase associated with familial Parkinson’s disease—are regulated by Hsp90 and its cochaperones. While previous studies have elucidated the mechanism of kinase loading into the Hsp90 machinery, the ...
Xuyang Tian, Jiayue Su, Ziyi Wang, Tao Liu, Huifang Xiong, Shan Sun, Kunrong Mei, Sen-Fang Sui   +7 more
doaj   +2 more sources

Integrating Single-Cell Transcriptomics and Mendelian Randomization to Identify RAC1 as a Causal Metabolic Driver of Pericyte Dysfunction in Systemic Sclerosis. [PDF]

Mediators Inflamm
Background Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular injury and progressive fibrosis. Although microvascular injury is an inciting event and pericytes are recognized as a major source of myofibroblasts, the precise phenotypic heterogeneity of pericytes in the SSc microenvironment and the genetic mechanisms driving ...
Wang X, Zhang Z, Jiang E, Zhang M, Hu G.
europepmc   +2 more sources