Results 11 to 20 of about 6,074 (204)

HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation

Nature Communications, 2022
Binding to HSP90-CDC37 is essential for the activity of many protein kinases, but its function is unclear. Here, the authors show that HSP90-CDC37 provides a structural platform for the phosphatase PP5 to dephosphorylate a bound kinase, ‘factory ...
Jasmeen Oberoi, Xavi Aran Guiu, Emily A. Outwin, Pascale Schellenberger, Theodoros I. Roumeliotis, Jyoti S. Choudhary, Laurence H. Pearl   +6 more
doaj   +4 more sources

Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes [PDF]

EMBO Journal, 2002
Cdc37 has been shown to be required for the activity and stability of protein kinases that regulate different stages of cell cycle progression. However, little is known so far regarding interactions of Cdc37 with kinases that play a role in cell division. Here we show that the loss of function of Cdc37 in Drosophila leads to defects in mitosis and male
Elena Rebollo, Cayetano Gonzalez
exaly   +4 more sources

Molecular mechanism of PINK1 regulation by the Hsp90 machinery [PDF]

Nature Communications
Hundreds of human kinases, including PINK1—a protein kinase associated with familial Parkinson’s disease—are regulated by Hsp90 and its cochaperones. While previous studies have elucidated the mechanism of kinase loading into the Hsp90 machinery, the ...
Xuyang Tian, Jiayue Su, Ziyi Wang, Tao Liu, Huifang Xiong, Shan Sun, Kunrong Mei, Sen-Fang Sui   +7 more
doaj   +2 more sources

Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements [PDF]

Communications Biology
RAF kinases are integral to the RAS-MAPK signaling pathway, and proper RAF1 folding relies on its interaction with the chaperone HSP90 and the cochaperone CDC37.
Lorenzo I. Finci, Mayukh Chakrabarti, Gulcin Gulten, Joseph Finney, Carissa Grose, Tara Fox, Renbin Yang, Dwight V. Nissley, Frank McCormick, Dominic Esposito, Trent E. Balius, Dhirendra K. Simanshu   +11 more
doaj   +2 more sources

AURKB/CDC37 complex promotes clear cell renal cell carcinoma progression via phosphorylating MYC and constituting an AURKB/E2F1-positive feedforward loop [PDF]

Cell Death and Disease
As the second most common malignant tumor in the urinary system, renal cell carcinoma (RCC) is imperative to explore its early diagnostic markers and therapeutic targets.
Fang Li, Xiaofei Wang, Jinyuan Zhang, Xintao Jing, Jing Zhou, Qiuyu Jiang, Li Cao, Shuang Cai, Jiyu Miao, Dongdong Tong, John Y-J. Shyy, Chen Huang   +11 more
doaj   +2 more sources

Therapeutic Potential of the Hsp90/Cdc37 Interaction in Neurodegenerative Diseases

Frontiers in Neuroscience, 2019
Alzheimer’s, Huntington’s, and Parkinson’s are devastating neurodegenerative diseases that are prevalent in the aging population. Patient care costs continue to rise each year, because there is currently no cure or disease modifying treatments for these ...
Liam Gracia, Gabriella Lora, Laura J. Blair, Umesh K. Jinwal   +3 more
doaj   +3 more sources

Bombinin-BO1 induces hepatocellular carcinoma cell-cycle arrest and apoptosis via the HSP90A-Cdc37-CDK1 axis [PDF]

iScience
Summary: Bombinin-BO1 (BO1), a bombinin peptide derived from the skin secretion of Bombina orientalis, exhibits broad-spectrum antimicrobial activity. To date, the anticancer effect of BO1 remains unclear.
Xiaoting Wang, Peiyu Tang, Yitong Gong, Hang Yao, Mingpeng Liang, Hongxia Qu, Xiao Han, Qiusheng Zheng, Zhen Shi, Defang Li, Qingling Jiang   +10 more
doaj   +2 more sources

Utilizing Multi-omics analysis to elucidate the role of mitochondrial gene defects in Gastric cancer progression. [PDF]

PLoS ONE
BackgroundGastric cancer is a leading cause of cancer-related mortality worldwide, with poor survival outcomes despite advances in diagnostic and therapeutic methods.
Jie Chu, Hanying Song, Kemin Fu, Wei Xiao, Jiudong Jiang, Qixin Gan, Bo Deng   +6 more
doaj   +2 more sources

Effect of the CSFV NS5A protein on key proteins in the MAPK and PI3K-mTOR signaling pathways in porcine macrophages [PDF]

Frontiers in Microbiology
Classical swine fever (CSF) is a highly contagious disease caused by classical swine fever virus (CSFV). NS5A, a non-structural protein of CSFV, plays an important role in regulating viral replication and protein translation.
Yidan Wang, Xiaoru Zheng, Yingying Yang, Xinru Zhao, Min Li, Juan Huang, Qiaoya Zhang, Xiaobing Qin, Ying Yu, Qing Pan, Zhi Cao   +10 more
doaj   +2 more sources

Self-Assembled Dictamni Cortex Nanoparticles Ameliorate Psoriasis by Epigenetic Modulation of HSP90AB1 and Suppression of the Inflammatory Response. [PDF]

Adv Sci (Weinh)
This study develops self‐assembled Dictamni Cortex (BXP)‐Fe(III) infinite coordination polymer nanoparticles (NB) to improve BXP's solubility and bioavailability for psoriasis. NB transdermally treats psoriasis by targeting the epigenetic regulator CTCF (CCCTC‐binding factor), suppressing HSP90AB1 (heat shock protein 90 alpha family class B member 1 ...
Zhang Z, Du W, Zhang X, Cui H, Cheng B, Han X, He K, Yin T, Liu X, Xian N, Wang Z, Liu M, Han D, Liu J, Zheng Y, Wang Y.   +15 more
europepmc   +2 more sources