Results 1 to 10 of about 9,442,423 (244)

Cell division cycle 37 change after bortezomib-based induction therapy helps to predict clinical response and prognosis in multiple myeloma patients

Hematology, 2023
Objective Cell division cycle 37 (CDC37) modulates disease progression and bortezomib resistance in multiple myeloma by regulating X-box binding protein 1, nuclear factor-kappa-B, etc.
Wuqiang Lin, Xiuli Chen, Heyong Zheng, Zhenjie Cai   +3 more
doaj   +1 more source

Rational design, synthesis and structural characterization of peptides and peptidomimetics to target Hsp90/Cdc37 interaction for treating hepatocellular carcinoma

Computational and Structural Biotechnology Journal, 2023
Heat shock protein 90 (Hsp90) and cell division cycle 37 (Cdc37) work together as a molecular chaperone complex to regulate the activity of a multitude of client protein kinases.
Surya Sukumaran, Mingdian Tan, Shulamit Fluss Ben-Uliel, Hui Zhang, Marta De Zotti, Mei-Sze Chua, Samuel K. So, Nir Qvit   +7 more
doaj   +1 more source

Identification of co-chaperone Cdc37 in Penaeus monodon: coordination with Hsp90 can reduce cadmium stress-induced lipid peroxidation

Ecotoxicology and Environmental Safety, 2021
Cell division cycle 37 (Cdc37) is an important cytoplasmic phosphoprotein, which usually functions as a complex with heat shock protein 90 (Hsp90), to effectively reduce the damage caused by heavy metals, such as cadmium (Cd), in aquatic animals.
Chao Zhao, Chao Peng, Pengfei Wang, Sigang Fan, Lulu Yan, Lihua Qiu   +5 more
doaj   +1 more source

Cdc48 and cofactors Npl4-Ufd1 are important for G1 progression during heat stress by maintaining cell wall integrity in Saccharomyces cerevisiae. [PDF]

PLoS ONE, 2011
The ubiquitin-selective chaperone Cdc48, a member of the AAA (ATPase Associated with various cellular Activities) ATPase superfamily, is involved in many processes, including endoplasmic reticulum-associated degradation (ERAD), ubiquitin- and proteasome ...
Meng-Ti Hsieh, Rey-Huei Chen
doaj   +1 more source

Ginsenoside Rg5 enhances the radiosensitivity of lung adenocarcinoma via reducing HSP90-CDC37 interaction and promoting client protein degradation

Journal of Pharmaceutical Analysis, 2023
Ginsenoside Rg5 is a rare ginsenoside showing promising tumor-suppressive effects. This study aimed to explore its radio-sensitizing effects and the underlying mechanisms. Human lung adenocarcinoma cell lines A549 and Calu-3 were used for in vitro and in 
Hansong Bai, Jiahua Lyu, Xinyu Nie, Hao Kuang, Long Liang, Hongyuan Jia, Shijie Zhou, Churong Li, Tao Li   +8 more
doaj   +1 more source

Recognition of BRAF by CDC37 and Re-Evaluation of the Activation Mechanism for the Class 2 BRAF-L597R Mutant

Biomolecules, 2022
The kinome specific co-chaperone, CDC37 (cell division cycle 37), is responsible for delivering BRAF (B-Rapidly Accelerated Fibrosarcoma) to the Hsp90 (heat shock protein 90) complex, where it is then translocated to the RAS (protooncogene product p21 ...
Dennis M. Bjorklund, R. Marc L. Morgan, Jasmeen Oberoi, Katie L. I. M. Day, Panagiota A. Galliou, Chrisostomos Prodromou   +5 more
doaj   +1 more source

Dynamic compartmentalization of the pro-invasive transcription factor NHR-67 reveals a role for Groucho in regulating a proliferative-invasive cellular switch in C. elegans

eLife, 2023
A growing body of evidence suggests that cell division and basement membrane invasion are mutually exclusive cellular behaviors. How cells switch between proliferative and invasive states is not well understood.
Taylor N Medwig-Kinney, Brian A Kinney, Michael AQ Martinez, Callista Yee, Sydney S Sirota, Angelina A Mullarkey, Neha Somineni, Justin Hippler, Wan Zhang, Kang Shen, Christopher Hammell, Ariel M Pani, David Q Matus   +12 more
doaj   +1 more source

Identification of crucial genes based on expression profiles of hepatocellular carcinomas by bioinformatics analysis [PDF]

PeerJ, 2019
Hepatocellular carcinoma (HCC) is one of the most heterogeneous malignant cancers with no effective targets and treatments. However, the molecular pathogenesis of HCC remains largely uncertain. The aims of our study were to find crucial genes involved in
Ze-Kun Liu, Ren-Yu Zhang, Yu-Le Yong, Zhi-Yun Zhang, Can Li, Zhi-Nan Chen, Huijie Bian   +6 more
doaj   +2 more sources

A global view of substrate phosphorylation and dephosphorylation during budding yeast mitotic exit

Microbial Cell, 2018
The cell cycle is the process by which a cell duplicates its DNA during S-phase and divides its chromosomes during M-phase, creating two genetically identical daughter cells.
Sandra A. Touati, Frank Uhlmann
doaj   +1 more source

miR-15a and miR-20b sensitize hepatocellular carcinoma cells to sorafenib through repressing CDC37L1 and consequent PPIA downregulation

Cell Death Discovery, 2022
Sorafenib is a classical targeted drug for the treatment of advanced hepatocellular carcinoma (HCC), but intrinsic resistance severely limited its therapeutic effects.
Li Li, Shijun Yu, Jingde Chen, Ming Quan, Yong Gao, Yandong Li   +5 more
doaj   +1 more source