Results 21 to 30 of about 9,442,423 (244)

Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery

Journal of Hematology & Oncology, 2018
Heat shock protein 90 (Hsp90) is a critical molecular chaperone protein that regulates the folding, maturation, and stability of a wide variety of proteins.
Ting Li, Hu-Lin Jiang, Yun-Guang Tong, Jin-Jian Lu   +3 more
doaj   +1 more source

Hsp90 S-nitrosylation at Cys521, as a conformational switch, modulates cycling of Hsp90-AHA1-CDC37 chaperone machine to aggravate atherosclerosis

Redox Biology, 2022
Endothelial dysfunction is the initial process of atherosclerosis. Heat shock protein 90 (Hsp90), as a molecular chaperone, plays a crucial role in various cardiovascular diseases. Hsp90 function is regulated by S-nitrosylation (SNO).
Shuang Zhao, Xin Tang, Zian Miao, Yurong Chen, Jiawei Cao, Tianyu Song, Daiting You, Yanqing Zhong, Zhe Lin, Dan Wang, Zhiguang Shi, Xinlong Tang, Dongjin Wang, Shaoliang Chen, Liansheng Wang, Aihua Gu, Feng Chen, Liping Xie, Zhengrong Huang, Hong Wang, Yong Ji   +20 more
doaj   +1 more source

Nek family of kinases in cell cycle, checkpoint control and cancer [PDF]

, 2011
Early studies in lower Eukaryotes have defined a role for the members of the NimA related kinase (Nek) family of protein kinases in cell cycle control. Expansion of the Nek family throughout evolution has been accompanied by their broader involvement in ...
Haider Nasir, Nasir Haider, Stambolic Vuk, Previn Dutt, Moniz, L, Larissa Moniz, Dutt Previn, Dutt, P, Haider, N, Stambolic, V, Moniz Larissa, Vuk Stambolic, Haider, Nasir, Dutt, Previn, Moniz, Larissa, Stambolic, Vuk   +15 more
core   +1 more source

Chromosome segregation impacts on cell growth and division site selection in Corynebacterium glutamicum. [PDF]

, 2013
Spatial and temporal regulation of bacterial cell division is imperative for the production of viable offspring. In many rod-shaped bacteria, regulatory systems such as the Min system and nucleoid occlusion ensure the high fidelity of midcell divisome ...
Marc Bramkamp, Bramkamp, Marc, Reinhard Krämer, Catriona Donovan (279787), Astrid Schauss (279788), Astrid Schauss, Catriona Donovan, Marc Bramkamp (251464), Krämer, Reinhard, Reinhard Krämer (68430), Donovan, Catriona, Schauss, Astrid   +11 more
core   +2 more sources

Temperature stress promotes cell division arrest in Xanthomonas citri subsp. citri

MicrobiologyOpen, 2016
Citrus canker is an economically important disease that affects orange production in some of the most important producing areas around the world. It represents a great threat to the Brazilian and North American citriculture, particularly to the states of
Júlia A. P. Sumares, Luana Galvão Morão, Paula M. M. Martins, Daniela A. B. Martins, Eleni Gomes, José Belasque Jr, Henrique Ferreira   +6 more
doaj   +1 more source

Growth regulation in Hydra. Relationship between epithelial cell cycle length and growth rate [PDF]

, 1984
The relationship between epithelial cell production and growth rate was investigated in Hydra attenuata under different feeding regimes. The increase of epithelial cell number was compared to the duration of the epithelial cell cycle using standard ...
Bosch, Thomas C. G., David, Charles N.
core   +1 more source

Therapeutic Potential of the Hsp90/Cdc37 Interaction in Neurodegenerative Diseases

Frontiers in Neuroscience, 2019
Alzheimer’s, Huntington’s, and Parkinson’s are devastating neurodegenerative diseases that are prevalent in the aging population. Patient care costs continue to rise each year, because there is currently no cure or disease modifying treatments for these ...
Liam Gracia, Gabriella Lora, Laura J. Blair, Umesh K. Jinwal   +3 more
doaj   +1 more source

Protein profiling of testicular tissue from boars with different levels of hyperactive sperm motility

Acta Veterinaria Scandinavica, 2022
Hyperactive sperm motility is important for successful fertilization. In the present study, a proteome profiling approach was performed to identify the differences between Landrace boars with different levels of hyperactive sperm motility in liquid ...
Maren van Son, Dag Inge Våge, Morten Skaugen, Nina Hårdnes Tremoen, Ann Helen Gaustad, Teklu Tewoldebrhan Zeremichael, Frøydis Deinboll Myromslien, Eli Grindflek   +7 more
doaj   +1 more source

Asynchronous nuclear division cycles in multinucleated cells [PDF]

, 2006
Synchronous mitosis is common in multinucleated cells. We analyzed a unique asynchronous nuclear division cycle in a multinucleated filamentous fungus, Ashbya gossypii.
Peter Philippsen, Gladfelter, A. S., Amy S. Gladfelter, A. Katrin Hungerbuehler, Hungerbuehler, A. K., Philippsen, P.   +5 more
core   +1 more source

Epidermal growth factor receptor promotes osteoclast differentiation probably through regulating ABCC1 and CDC37

陆军军医大学学报
Objective To observe the expression profile of epidermal growth factor receptor (EGFR) during the differentiation of osteoclasts, and to explore EGFR-related signaling pathways and key genes during the process.
TAN Xin, ZHANG Ziyuan, LIU Xing
doaj   +1 more source