Results 31 to 40 of about 9,442,423 (244)

Hsp90 modulates human sperm capacitation via the Erk1/2 and p38 MAPK signaling pathways

Reproductive Biology and Endocrinology, 2021
Background Heat shock protein 90 (Hsp90) is a highly abundant eukaryotic molecular chaperone that plays important roles in client protein maturation, protein folding and degradation, and signal transduction.
Peibei Sun, Yayan Wang, Tian Gao, Kun Li, Dongwang Zheng, Ajuan Liu, Ya Ni   +6 more
doaj   +1 more source

Information homeostasis as a fundamental principle governing the cell division and death [PDF]

, 2011
To express genetic information with minimal error is one of the key functions of a cell. Here we propose an information theory based phenomenological model for the expression of genetic information.
Singh, Harinder Pal, Harinder Pal Singh, Harinder P. Singh, Kumar, Arvind, Arvind Kumar   +4 more
core   +1 more source

3D structure prediction of replication factor C subunits (RFC) and their interactome in Arabidopsis thaliana [PDF]

Network Biology, 2013
DNA stress can causes potentially spontaneous genome damage during DNA replication process. Proteins involved in this process are DNA-dependent ATPases, required for replication and repair.
Mohamed Ragab Abdel Gawwad, Jasmin Sutkovic, Emina Zahirovic, et al.   +2 more
doaj  

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Cell cycle-dependent regulation of structure of endoplasmic reticulum and inositol 1,4,5-trisphosphate-induced Ca2+ release in mouse oocytes and embryos [PDF]

, 2003
The organization of endoplasmic reticulum (ER) was examined in mouse eggs undergoing fertilization and in embryos during the first cell cycle. The ER in meiosis 11 (MII)-arrested mouse eggs is characterized by accumulations (clusters) that are restricted
Carroll, J, Marangos, P, FitzHarris, G
core  

Multilevel regulation of RUVBL2 expression predicts poor prognosis in hepatocellular carcinoma

Cancer Cell International, 2019
Background Hepatocellular carcinoma (HCC) is the second-most lethal cancer worldwide with a complex pathogenesis. RuvB-like 2 (RUVBL2) was previously found to contribute to hepatocarcinogenesis.
Tao Yan, Fang Liu, Jiajia Gao, Haizhen Lu, Jianqiang Cai, Xiaohang Zhao, Yulin Sun   +6 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

MEK1/2 regulates microtubule organization, spindle pole tethering and asymmetric division during mouse oocyte meiotic maturation

, 2007
It is well known that MAPK plays pivotal roles in oocyte maturation, but the function of MEK (MAPK kinase) remains unknown. We have studied the expression, subcellular localization and functional roles of MEK during meiotic maturation of mouse oocytes ...
Bo Xiong, Qing-Yuan Sun, Wang, Chun Min, Zhi-Sheng Zhong, Kui Liu, Schatten, Heide, Yi Hou, Wang, Qiang, Chen, Da-Yuan, Yu, Ling-Zhu, Zhong, Zhi-Sheng, Wang, Chun-Min, Sun, Qing-Yuan, Liu, Kui, Zhong, Zhi Sheng, Da-Yuan Chen, Qiang Wang, Gao, Wen Xue, Huo, Li-Jun, Yu, Ling Zhu, Liu, X. Johne, Sun, Qing Yuan, Huo, Li Jun, Chen, Da Yuan, Wen-Xue Gao, Ling-Zhu Yu, Li-Jun Huo, Xiong, Bo, Heide Schatten, Gao, Wen-Xue, Chun-Min Wang, Johné Liu, Hou, Yi   +32 more
core   +1 more source