Results 51 to 60 of about 375,820 (259)

On the regulation of chromosome segregation in human cells : implications of Bub1 Kinase inhibition during cell division [PDF]

, 2015
The maintenance of correct chromosome number (euploidy) during cell division is essential for health. Loss of euploidy is observed in most cancers and is linked to tumorigenesis.
Baron, Anna
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Rab11A-controlled assembly of the inner membrane complex is required for completion of apicomplexan cytokinesis [PDF]

, 2009
The final step during cell division is the separation of daughter cells, a process that requires the coordinated delivery and assembly of new membrane to the cleavage furrow.
Manuel Rauch, Naissant, B., Sabine Thiberge, Langsley, G., Fathia Ben Rached, Ben Rached, F., Meissner, M, Meissner, M., Rauch, M., Angelika Kretzschmar, Agop-Nersesian, C., Kretzschmar, A., David J P Ferguson, Menard, R., Langsley, G, Ferguson, DJP, Ben Rached, F, Ferguson, DJ, Markus Meissner, David J. P. Ferguson, Rauch, M, Carolina Agop-Nersesian, Naissant, B, Agop-Nersesian, C, Robert Menard, Thiberge, S., Kretzschmar, A, Menard, R, Gordon Langsley, Thiberge, S, Ferguson, D.J.P., Bernina Naissant   +31 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Gap junctions modulate interkinetic nuclear movement in retinal progenitor cells

, 2005
During early retinal development, progenitor cells must divide repeatedly to expand the progenitor pool. During G1 and G2 of the cell cycle, progenitor cell nuclei migrate back-and-forth across the proliferative zone in a process termed interkinetic ...
Lüneborg, N.L., Mobbs, Peter, Becker, D.L., Becker, David L., Pearson, R.A., Mobbs, P., Pearson, Rachael A.; id_orcid, Lüneborg, Nanna L.   +7 more
core   +1 more source

Perturbation of cytokinin and ethylene-signalling pathways explain the strong rooting phenotype exhibited by Arabidopsis expressing the Schizosaccharomyces pombe mitotic inducer, cdc25 [PDF]

, 2012
Background Entry into mitosis is regulated by cyclin dependent kinases that in turn are phosphoregulated. In most eukaryotes, phosphoregulation is through WEE1 kinase and CDC25 phosphatase.
Marchbank, A., Doonan, John, DOONAN J., Prinsen, Els, Angela Marchbank, Rogers Hilary J, Sherong Li, MARCHBANK A., Bruno, Leonardo, PRINSEN E., Li, Sherong, Spadafora Natasha D, Rogers HJ, FRANCIS D., Li Sherong, Doonan J, Diego Albani, Francis D, Parfitt, David, Nieuwland Jeroen, John Doonan, Bitonti MB, Buchanan-Wollaston, Vicky, Natasha Spadafora, Hilary Rogers, Spadafora, Natasha, Rogers, H.J., Vaughn, R., Li S, Parfitt, D., Albani Diego, Bruno Leonardo, Marchbank A, Vaughan R, Nieuwland, Jeroen, BITONTI M. B., Bruno L, Herbert RJ, Spadafora, N.D., Robert Herbert, Marchbank, Angela Maureen, HERBERT R., Li, S., Francis, Dennis, Rhys Vaughan, Albani, Diego Maria, Dennis Francis, Li S., Prinsen Els, Rogers, Hilary J., Leonardo Bruno, Spadafora, Natasha D., SPADAFORA D., PARFITT D., Herbert Robert J, Prinsen E, Vaughan, Rhys, David Parfitt, Jeroen Nieuwland, Francis Dennis, Bruno, L., Herbert, Rob, Bitonti, M.B., Prinsen, E., Maria Beatrice Bitonti, Rogers, Hilary Joan, Els Prinsen, Albani, Diego, Vicky Buchanan-Wollaston, VAUGHAN R., Francis, D. (Dennis), Buchanan-Wollaston Vicky, Spadafora ND, Rogers, Hilary, Herbert, Robert, ROGERS H. R., Nieuwland, J., Albani, D., Parfitt David, Doonan John, Doonan, J., ALBANI D., Buchanan Wollaston V, Buchanan-Wollaston, V., Bitonti, Maria Beatrice, Parfitt D, Nieuwland J, BRUNO L., Marchbank Angela, WOLLASTON B., Bitonti Maria, Francis, D., Marchbank, Angela, Vaughan Rhys, NIEUWLAND J.   +94 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Quantitative analysis of septin Cdc10 & Cdc3-associated proteome during stress response in the fungal pathogen Cryptococcus neoformans.

PLoS ONE
Cryptococcus neoformans is a pathogenic basidiomycetous yeast that primarily infects immunocompromised individuals. Fatal outcome of cryptococcosis depends on the ability of C. neoformans to sense and adapt to 37°C.
Stephani Martinez Barrera, Emma Hatchell, Stephanie D Byrum, Samuel G Mackintosh, Lukasz Kozubowski   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source