Results 211 to 220 of about 109,885 (301)

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Testicular Heat-Shock Protein Expression in Rats Following 3.5 GHz and 24 GHz RF-EMF Exposure. [PDF]

Int J Mol Sci
Syed Taha SMA, Jaffar FHF, Hairulazam A, Vijay S, Jamaludin N, Zulkefli AF, Mat Ros MF, Osman K, Zakaria Z, Mohd Bahar MAA, Ibrahim SF.   +10 more
europepmc   +1 more source

An optimized, broadly applicable piggyBac transposon induction system [PDF]

, 2017
Chen, Xuhua, Mayhew, David, Mitra, Robi David, Qi, Zongtai, Sankararaman, Sumithra, Wilkinson, Michael Nathaniel   +5 more
core   +2 more sources

CRISPR/Cas9‐Based Vanadium MXene‐Free Radical Spatiotemporally Controlled Nanoreactor for Photothermal‐Induced Multi‐Effect Synergistic Antitumor Therapy

Advanced Science, Volume 13, Issue 29, 22 May 2026.
In this study, a MXene‐based V4C3 nanoplatform, VARH, was constructed, which achieved a photothermal conversion efficiency of 44.21% in the NIR‐II window. This platform integrated photothermal therapy, chemodynamic therapy, and thermodynamic therapy with CRISPR/Cas9‐mediated heat shock protein 90 knock‐out technology.
Zi‐Jian Huang, Feng‐Ming Li, Yi‐Fan Tu, Ke‐Ke Feng, Cheng‐Lei Li, Shi‐Cheng Tian, Yong‐Shan Hu, Jing‐Wei Shao, Zhen‐Hua Liu   +8 more
wiley   +1 more source

Attempts to Achieve Targeted Covalent Inhibition of Hsp90β. [PDF]

Chem Biol Drug Des
D'Amico T, Reynolds TS, Serwetnyk MA, Blagg BSJ.   +3 more
europepmc   +1 more source

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science, Volume 13, Issue 28, 18 May 2026.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
wiley   +1 more source

Hypertension and Diabetes Cooperatively Drive HSP90 Activation, HSP70 Suppression, and Left Ventricular Interstitial Expansion: Relevance to Maladaptive Myocardial Remodeling. [PDF]

Pathophysiology
Sklifasovskaya AP, Blagonravov ML, Azova MM, Kurevlev SV, Goryachev VA, Syatkin SP, Zotova TY, Prokofiev DY.   +7 more
europepmc   +1 more source

Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants

Advanced Science, Volume 13, Issue 27, 13 May 2026.
The diversity of plant condensates reflects constraints of sessile organisms to coordinate postembryonic development with environmental adaptation. This review examines how plants employ condensates to integrate temperature, light, redox, and nutrient signals.
Panagiotis N. Moschou, Dorothee Staiger
wiley   +1 more source

ClC-3 mediates angiotensin II-induced endothelial dysfunction by inhibiting Akt-Hsp90-eNOS signaling pathway. [PDF]

Front Pharmacol
Li L, Lin YQ, Peng YS, Chen HH, Wu XJ, Liang G, Du YH.   +6 more
europepmc   +1 more source

Single‐cell transcriptomic analysis reveals APOE genotype‐dependent sex differences in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) is the most common form of dementia, with approximately two‐thirds of AD patients being female. Basic and clinical research studies provide strong evidence that sex‐specific differences contribute to AD complexity.
Gefei Yu, Abigail Thorpe, Qi Zeng, Erming Wang, Alison Goate, Dongming Cai, Minghui Wang, Bin Zhang   +7 more
wiley   +1 more source