Results 191 to 200 of about 76,334 (253)

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, Volume 78, Issue 9, Page 1989-1999, September 2026.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Ge-Gen Decoction Modulates the HSP90/AKT Signaling Pathway and the NLRP3 Inflammasome to Alleviate Primary Dysmenorrhea. [PDF]

J Pain Res
Xie Y, Xu L, He Y.
europepmc   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, Volume 4, Issue 3, September 2026.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies. [PDF]

Adv Sci (Weinh)
Zhang B, Zou X, Zhou J, Sun Q, Chen D.
europepmc   +1 more source

Phytochemical Profiling and Biological Evaluation of Pistacia lentiscus L. grown in Chlef (Algeria): An Integrated In Vitro, In Vivo, and In Silico Study

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The antihypoxic and antioxidant activities of Pistacia lentiscus L. extract are assessed. High total phenolics and flavonoids contents are noted. Various phenolic acids and flavonoids are identified via HPLC‐MS analysis. The extract demonstrates important scavenging and reducing power, enhances mice survival under normobaric hypoxia, and reduces ...
Halima Saiah, Ali Zineddine Boumehira, Wassila Saiah, Salima Boudane, Asma Al‐farajein   +4 more
wiley   +1 more source

Plasmodium falciparum HSP90 inhibitors show divergent resistance despite a shared ATP-binding site. [PDF]

Cell Rep
Ko FH, Lukens AK, Laureano de Souza M, Foy A, Hsiao J, Ndiaye T, Okombo J, Yeo T, Park H, Uhlemann AC, Boonyalai N, Kumpornsin K, Girling G, Pasaje C, Godoy L, Kapoor P, Durst GL, Ottilie S, Chatterjee A, Niles J, Lee M, Fidock DA, Wirth DF, Winzeler EA.   +23 more
europepmc   +1 more source

CRISPR/Cas9‐Mediated Editing of Four Ca2+‐Binding Receptor‐Like Cytoplasmic Kinases Improves Soybean Seed Size and Yield at Dense Planting

Plant Biotechnology Journal, Volume 24, Issue 10, Page 5369-5371, October 2026.
Wanhong Li, Jun Jin, Tianyue Gu, Xiaoxi Cai, Bowei Jia, Yan Wang, Dezhi Han, Xiaofei Yan, Xiping Hu, Xiaoli Sun, Sijia Lu, Mingzhe Sun   +11 more
wiley   +1 more source

Interactions Between E3 Ubiquitin Ligases and Deubiquitinases in AKT Regulation: Implications in Skeletal Muscle Homeostasis

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT AKT (protein kinase B, PKB) coordinates the balance between anabolic and catabolic signaling in skeletal muscle through distinct ubiquitin chain types. Some E3 ubiquitin ligases (E3s) and deubiquitinases (DUBs) form stable binary complexes via non‐catalytic interfaces, adding a regulatory layer unavailable to either enzyme alone.
Rajesh Dabur
wiley   +1 more source

Beyond Inhibition: Rebalancing the Hsp90 Chaperone Network as a Therapeutic Strategy for Alzheimer's Disease. [PDF]

Drug Des Devel Ther
Tang Z, Xie H, Xu Y, Zhou Z, Lu F, Wu Q, Liang W, Zhong M, Li S.   +8 more
europepmc   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, Volume 2, Issue 3, September 2026.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source