Results 191 to 200 of about 109,885 (301)

Beyond a Passive Tether: Structural Insights into the Disordered Tail of Hsp90. [PDF]

J Am Chem Soc
Edinach E, Giannouli A, Dalaloyan A, Oranges M, Banik D, Yardeni EH, Elimelech A, Sattler M, Ntermanakis E, Su XC, Goldfarb D.   +10 more
europepmc   +1 more source

PAX8‐positive conventional urothelial carcinomas of the urinary bladder and their distinct molecular profiles – A clinicopathologic study of 101 consecutive cases with next‐generation sequencing in 20 cases

Histopathology, Volume 88, Issue 7, Page 1315-1323, June 2026.
PAX8 expression in urothelial carcinoma was investigated in 101 consecutive transurethral resections of the urinary bladder. PAX8 was positive in 10% of cases, with targeted molecular testing of these cases revealing universal TERT promoter mutations and frequent alterations in TSC1, NOTCH1 and WT1. Aims PAX8 immunohistochemistry (IHC) is often used to
Sarah Mae Lammert, Wendy Luo, Allen C Zhu, Peng Wang, Tatjana Antic, Jung Woo Kwon   +5 more
wiley   +1 more source

Genome-wide comparative analysis of the HSP90 gene family in four Ipomoea species and functional insights into the potentiality of IbHSP90-2 in low temperature tolerance. [PDF]

Front Plant Sci
Shu L, Zhu K, Wang X, Cheng L, Zhou S, Zhu M, Gou X, Li Z.   +7 more
europepmc   +1 more source

Development of the HTRF assay to evaluate the auxin‐induced binding between TIR1 and IAA7

New Phytologist, Volume 250, Issue 5, Page 3475-3485, June 2026.
Summary Auxin plays diverse roles in plant growth and development, including sensing environmental changes. Quantifying the interaction between auxin coreceptors provides the molecular basis for cells to sense and adapt to environmental cues. Although several assays are available, a more high‐throughput method is necessary to efficiently evaluate the ...
Jekson Robertlee, Shinya Hagihara
wiley   +1 more source

Enabling Synthetically Feasible Molecular Editing in Drug Discovery via Reaction-Regulated Graph-Based Genetic Algorithms. [PDF]

JACS Au
Moon SW, Ahn SH, Ahn JH, Kim HW.
europepmc   +1 more source

Breaking the Heat Tolerance Response: The Crucial Role of MFAP4 in Combating Heat‐Induced Cardiac Injury

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
MFAP4 deficiency exacerbates heatstroke outcomes, accelerating hyperthermia, delaying recovery, reducing survival, and worsening cardiac injury. Conversely, MFAP4 overexpression enhances cellular thermoresistance. MFAP4 orchestrates transcriptional reprogramming in response to HS.
LiJun Fan, MingXiao Song, QingHan Zhang, ZiYi Guo, Jing Wang, XueWei Chen, ChenYi Hu, JunYu Lu, ZhuGe Xi   +8 more
wiley   +1 more source

Identification of drug candidates against glioblastoma with machine learning and high-throughput screening of heterogeneous cellular models.

Digit Discov
Smer-Barreto V, Elliott RJR, Dawson JC, Lorente-Macías Á, Furqan M, Unciti-Broceta A, Oyarzún DA, Carragher NO.   +7 more
europepmc   +1 more source

GABARAPL1 is important for the activation of HRI during eIF2α phosphorylation-dependent stress response to sodium arsenite. [PDF]

Sci Rep
Campenet S, Lamarre M, Durand J, Perez V, Peixoto P, Delage-Mourroux R, Guittaut M, Baguet A, Despouy G.   +8 more
europepmc   +1 more source

Plasminogen Activator Inhibitor‐1 is Internalized by Endothelial Cells via A Pinocytosis‐Like Mechanism and Evades Degradation

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Plasminogen activator inhibitor 1 (PAI1) is a secreted protein that also regulates intracellular processes, such as inhibition of endothelial nitric oxide synthase (eNOS). Interaction between Plasminogen Activators (PA) and PAI1 results in a covalent linkage.
Molly McAdow, Gjina Ahmetaj, Rachel Hauschel, Anne Eichmann, William Sessa   +4 more
wiley   +1 more source

Galleria mellonella infected with Bacillus thuringiensis involves Hsp90

Open Life Sciences, 2013
Wojda Iwona, Kowalski Patryk
doaj   +1 more source