Results 201 to 210 of about 109,885 (301)

Novel Hsp90 inhibitor JD‑02 inhibits HSV‑1 infection via the Raf/MEK/ERK signaling pathway. [PDF]

Int J Mol Med
Zhu Y, Wang X, Lin J, Wang X, Zheng K, Ren Z, Xiao J, Wang Y.   +7 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, Volume 20, Issue 5, Page 1253-1269, May 2026.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Heat shock protein Gp96 (Grp94) in malaria: functional insights at the host-parasite interface and therapeutic perspectives. [PDF]

Front Cell Dev Biol
Djoumoi D, Diouara AAM, Diop M, Nguer CM, Mbengue B, Thiam F.   +5 more
europepmc   +1 more source

Biomimetic Copper Nanoparticles Coated with ACE2‐Overexpressing Membranes for Selective SARS‐CoV‐2 Neutralization and Disinfection

Advanced Healthcare Materials, Volume 15, Issue 17, 8 May 2026.
By fusing ACE2‐overexpressing membrane‐integrated liposome (MIL) with copper nanoparticles, the biomimetic Cu@MIL nanostructures were created that directly hijack the SARS‐CoV‐2 entry pathway. These particles combine potent virus‐targeting precision with intrinsic antiviral activity, achieving rapid neutralization and disinfection.
Pooja Aich, Wei‐Pang Chung, Wen‐Jyun Wang, Hidenobu Takahashi, Ming‐Shun Hsieh, Ying‐Chen Lin, Oh Seok Kwon, Wei‐Peng Li, Wei‐Lun Huang   +8 more
wiley   +1 more source

Heat shock proteins (Hsp70 and Hsp90) in neurodegeneration: pathogenic roles and therapeutic potential. [PDF]

Front Aging Neurosci
Ben Khalaf N.
europepmc   +1 more source

Noninvasive Promotion of Neuronal Differentiation in Human Neural Progenitor Cells Using Terahertz Wave Illumination

Advanced Photonics Research, Volume 7, Issue 5, May 2026.
Terahertz (THz) waves provide a nonionizing and noninvasive approach to regulate neuronal differentiation by resonantly interacting with biomolecular vibrational modes. THz irradiation regulates gene expression and intracellular signaling pathways, enhancing neuronal marker expression and promoting neurite outgrowth. This biophysical modulation enables
Chaeeun Kim, Jisung Kwak, Daehwan Park, Hyun Gyu Song, Hye Young Son, Seung Jae Oh, Minah Seo, Hyun Seok Song, Taehee Kang   +8 more
wiley   +1 more source

[Expression of Concern] Dexmedetomidine protects against sepsis‑associated encephalopathy through Hsp90/AKT signaling. [PDF]

Mol Med Rep
Yin L, Chen X, Ji H, Gao S.
europepmc   +1 more source

Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy‐Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis

Advanced Science, Volume 13, Issue 25, 4 May 2026.
HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang, Maodong Leng, Chenchen Sun, Jingyu Cao, Linfei Li, Yangyang Jia, Yongshuai Han, Yuchun Liu, Yaodong Zhang, Chenglong Zhang, Yingli Men, Ningyuan Liu, Yibing Cheng, Yixia Zhang, Ya Li, Zhenlong Li, Lidan Cui, Xiangzhan Zhu   +17 more
wiley   +1 more source

Embracing diversity: Post-translational modifications, the chaperone code, and the emergence of new chaperone entities. [PDF]

Cell Stress Chaperones
Digwal CS, Wang S, Chiosis G.
europepmc   +1 more source

Tumor suppressor Tsc1 is a new Hsp90 co‐chaperone that facilitates folding of kinase and non‐kinase clients [PDF]

, 2017
et al,, Gutmann, David H, Rensing, Nicholas, Wong, Michael   +3 more
core   +1 more source