Results 181 to 190 of about 76,334 (253)

Lysosome‐Targeted Squaramide Anion Transporters

Chemistry – A European Journal, Volume 32, Issue 36, 24 September 2026.
Lysosome‐targeted squaramide anion transporters elicit different biological effects depending on the targeting group employed. ABSTRACT Targeting anion transporters to specific organelles has previously been shown to be an effective strategy to enhance their cytotoxicities against cancerous cell lines.
Elba Feo, Edward York, Anthony Thai, William G. Ryder, Daniel A. McNaughton, Philip A. Gale   +5 more
wiley   +1 more source

Post-Translational Modification as an Allosteric Switch in Hsp90: How Dual Phosphorylation Locks Chaperone Complexes into Hyperstabilized States. [PDF]

J Phys Chem Lett
Bonollo G, Roncati B, Torielli L, Wang S, Pasala C, Pavoni S, Frigerio F, Cinquini F, Chiosis G, Serapian SA, Colombo G.   +10 more
europepmc   +1 more source

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

Evolution of Hsp90 targeting: From stress biology to clinical translation. [PDF]

Cell Stress Chaperones
Zarguan I, Belayachi L, Benjouad A, Chadli A.   +3 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, Volume 20, Issue 9, Page 2296-2322, September 2026.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

An isotype-specific phosphorylation of Hsp90 rewires co-chaperone regulations. [PDF]

J Biol Chem
Banerjee T, Moroni E, Riedl M, Colombo G, Buchner J.   +4 more
europepmc   +1 more source

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, Volume 15, Issue 36, 25 September 2026.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

Comment on Sklifasovskaya et al. Hypertension and Diabetes Cooperatively Drive HSP90 Activation, HSP70 Suppression, and Left Ventricular Interstitial Expansion: Relevance to Maladaptive Myocardial Remodeling. <i>Pathophysiology</i> 2026, <i>33</i>, 19. [PDF]

Pathophysiology
Amaç B.
europepmc   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, Volume 13, Issue 50, 7 September 2026.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Sorafenib Restores Pentose Phosphate Pathway-Related Redox Homeostasis via the c-Raf/HSP90/G6PD Axis in Hepatic Ischemia-Reperfusion Injury. [PDF]

MedComm (2020)
Gao F, Dong L, Tan Y, Zhang Z, Xu S, Lou Z, Wu Y, Chen S, Zhuang L, Lian Z, Zheng S, Qiu N, Wang K, Xu X.   +13 more
europepmc   +1 more source