Results 181 to 190 of about 109,885 (301)

HSP90 inhibition potentiates oxidant-based antimelanoma action of novel thioquercetin derivatives by compromising AhR/CYP1A1 pathway. [PDF]

Apoptosis
Witkowski W, Słaby J, Wnuk M, Stec P, Piotrowski P, Żebrowski M, Cybularczyk-Cecotka M, Deręgowska A, Romanchikova N, Zayakin P, Linē A, Moros M, Litwinienko G, Lewińska A.   +13 more
europepmc   +1 more source

The Hsp90 Chaperone Machinery [PDF]

Journal of Biological Chemistry, 2008
Sebastian Karl, Wandinger, Klaus, Richter, Johannes, Buchner   +2 more
openaire   +2 more sources

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

A centralized interactive tool for genomic data on heat shock protein 90 in Fagaceae species. [PDF]

BMC Genomics
Postigo-Luque R, Guijo-Rubio D, Martín MÁ, Castro P, Die JV.   +4 more
europepmc   +1 more source

The role of the nucleus in the control of mitochondrial precursor proteins in yeast

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Mitochondria are essential organelles of eukaryotic cells, with vital roles in energy production, biosynthesis of macromolecules, and intracellular signaling. Their function depends on a complex proteome with proteins targeted to different mitochondrial sub‐compartments.
Kira Ritzenhofen, Stefano Rossi, Axel Mogk, Fabian den Brave   +3 more
wiley   +1 more source

Synaptic Chaperone Dysfunction as a Convergent Mechanism in Neurodegenerative and Psychiatric Disorders. [PDF]

Neurosci Insights
Jean D, Li Y.
europepmc   +1 more source

Dynamic disorder is crucial for mitochondrial protein import

Protein Science, Volume 35, Issue 6, June 2026.
Abstract The import of proteins into mitochondria poses fundamental mechanistic challenges: aggregation‐prone precursor proteins must be maintained in aqueous compartments and threaded through narrow pores without becoming stuck or mislocalized. Recent evidence from mitochondrial protein import studies and other chaperone systems underscores the ...
Jakob Schneider, Undina Guillerm, Caroline Simões Pereira, Paul Schanda   +3 more
wiley   +1 more source

Toward Personalized Medicine in Type 1 Diabetes: Understanding How Patient Heterogeneity Influences Therapeutic Efficacy

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4529-4545, June 2026.
ABSTRACT Pharmacologic interventions for type 1 diabetes (T1D) have advanced significantly in recent years with the advent of the first FDA approved therapy teplizumab for delaying symptomatic disease onset in 2022. Despite this progress, major hurdles remain in moving toward personalized medicine approaches for T1D.
Jasmine Pipella, Peter J. Thompson
wiley   +1 more source

Comparative analysis of the impact of Heat shock protein 90 kDa or Cdc37 mutation on the yeast proteome. [PDF]

Cell Stress Chaperones
Rios EI, Johnson JL.
europepmc   +1 more source

Internalized Evolutionary Inertia on Body Plan Evolution

Evolution &Development, Volume 28, Issue 2, June 2026.
Animal development appears to intrinsically bias phenotypic evolution, though the exact mechanism is unclear. This review discusses potential mechanisms by which animal embryogenesis limits phenotypic diversification and considers whether inherent evolutionary inertia could allow us to predict future evolutionary paths.
Wenxin Zeng, Naoki Irie
wiley   +1 more source