Results 171 to 180 of about 58,138 (243)

[Retracted] Hsp90 inhibitor 17‑AAG inhibits stem cell‑like properties and chemoresistance in osteosarcoma cells via the Hedgehog signaling pathway. [PDF]

Oncol Rep
Shu X, Liu H, Zhen R, Jie Y, Chen L, Qi H, Wang C, Wang R, Chen D, Ran Y.   +9 more
europepmc   +1 more source

OsCPN10a, cooperating with OsCPN20 and OsHSP60‐3B negatively regulate ABA signaling and enhance seed storability in rice

Journal of Integrative Plant Biology, Volume 68, Issue 7, Page 2242-2263, July 2026.
Abscisic acid signaling homeostasis is essential for seed storability. The molecular chaperone OsCPN10a enhances rice seed storability by forming a trimeric chaperone complex with OsCPN20‐OsHSP60‐3B that attenuates abscisic acid signaling via direct interaction with OsPYL10‐OsABIL1, thereby maintaining starch integrity and offering a promising target ...
Sufeng Liao, Yidong Wei, Yongsheng Zhu, Kunyang Li, Ting Chen, Shuai Zhao, Fangxi Wu, Jinlan Wang, Pengbo Yu, Hongguang Xie, Liping Chen, Qiuhua Cai, Huaan Xie, Jianfu Zhang   +13 more
wiley   +1 more source

Targeting HSP90 in cancer: advances in the development of inhibitors, mechanisms of action, and therapeutic applications. [PDF]

Mol Cancer
Wang X, Ni R, Wang X, Li X.
europepmc   +1 more source

Late Blight Effector Pi05910 Suppresses Plant Immunity by Promoting Destabilisation of Host Scaffold Protein RACK1

Molecular Plant Pathology, Volume 27, Issue 7, July 2026.
The core RXLR effector Pi05910 of P. infestans suppresses host immunity and growth by promoting destabilisation of its binding protein RACK1 via the 26S proteasome pathway, leading to the suppression of PTI and protein translation. ABSTRACT Late blight, caused by oomycete pathogen Phytophthora infestans, is one of the most devastating diseases of ...
Xiong Liu, Yisa Wang, Song Liu, Xiran Li, Liwen Ding, Altyn Shayakhmetova, Yuling Meng, Weixing Shan   +7 more
wiley   +1 more source

<i>TP53</i>-mutant AML with ribosomal gene loss exhibits impaired protein translation and sensitivity to HSP90 inhibition. [PDF]

Sci Adv
Spinella JF, Chagraoui J, Moison C, Boivin I, Carpentier GR, Mayotte N, Béliveau F, Lavallée VP, Hébert J, Sauvageau G.   +9 more
europepmc   +1 more source

The Moniliophthora roreri Effector MrB1 Affects Cellular Homeostasis and Induces Genotype‐Dependent Necrosis in Theobroma cacao

Molecular Plant Pathology, Volume 27, Issue 7, July 2026.
The effector MrB1 induces cytotoxicity in plant cells through oxidative stress, membrane damage, protein folding collapse, and energy failure. These alterations compromise cellular integrity and result in necrosis. ABSTRACT Frosty pod rot (FPR) is an invasive disease responsible for severe yield losses of cacao trees.
Taís Araújo Santos, Maria Luíza do Carmo Santos, Monaliza Macêdo Ferreira, Keilane Silva Farias, Carlos Henrique de Carvalho Neto, Ronan Xavier Corrêa, Uilson Vanderlei Lopes, Carlos Priminho Pirovani   +7 more
wiley   +1 more source

The evolution of heat shock protein 90 C-terminal inhibitors: From novobiocin to potential clinical candidates. [PDF]

Cell Stress Chaperones
Jiang X, Blagg BSJ.
europepmc   +1 more source

Enhancing Tolerance to Combined Heat and Drought Stress in Cool‐Season Grain Legumes: Mechanisms, Genetic Insights, and Future Directions

Plant, Cell &Environment, Volume 49, Issue 7, Page 3848-3870, July 2026.
ABSTRACT The increasing frequency of concurrent heat and drought stress poses a significant challenge to agricultural productivity, particularly for cool‐season grain legumes, including broad bean (Vicia Faba L.), lupin (Lupinus spp.), lentil (Lens culinaris Medik), chickpea (Cicer arietinum L.), grasspea (Lathyrus sativus L.), pea (Pisum sativum L ...
Manu Priya, Muhammad Farooq, Kadambot H. M. Siddique   +2 more
wiley   +1 more source

Antivirulence Strategy against <i>Candida albicans</i>: Cumin Essential Oil Attenuates Virulence and Enhances Host Immune Defense. [PDF]

ACS Omega
Mahesh N, Harith A, Melge AR, Nandini A, Madhavan A, Abhinand K, Prakash PY, Nair BG, Kumar GB, Haripriyan J.   +9 more
europepmc   +1 more source

Quinazolinone and Phthalazinone Inhibitors of the HDAC6/Ubiquitin Protein–Protein Interaction

ChemBioChem, Volume 27, Issue 12, 26 June 2026.
Here, we report the validation and expansion of small‐molecule inhibitors targeting the HDAC6 ZnF‐UBD pocket. Following molecular modeling, hits were synthesized, and candidate compounds were tested in fluorescence polarization of ubiquitin C‐terminal peptide displacement.
Sydney Gordon, Jordi C. J. Hintzen, Sebastian Dilones, Brockton Keen, Callie E. W. Crawford, George M. Burslem   +5 more
wiley   +1 more source