Results 61 to 70 of about 108,942 (214)
Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future [PDF]
, 2015 Constitutively activated prosurvival pathways render cancer cells addicted to their effects. Consequently they turn out to be the Achilles’ heels whose inhibition can be exploited in anticancer therapy.
CIRONE, Mara +6 more
core +9 more sources
Integrative Approaches to Treating Cellular Senescence in Kidney Disease
Advanced Science, EarlyView.ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa +3 more
wiley +1 more source
RNAi knockdown of heat shock proteins affects thermotolerance of Ephestia kuehniella (Lepidoptera: Pyralidae) [PDF]
Journal of Crop ProtectionThe Mediterranean flour moth, Ephestia kueheniella is one of the most severe pests in stores worldwide. Like many other stored product pests, chemical pesticides are often used to control this insect.
Ali Reza Bandani, Saeed Farahani
doaj +1 more source
Hsp90 is involved in apoptosis of Candida albicans by regulating the calcineurin-caspase apoptotic pathway. [PDF]
PLoS ONE, 2012 Candida albicans is the most common human fungal pathogen. Recent evidence has revealed the occurrence of apoptosis in C. albicans that is inducible by environmental stresses such as hydrogen peroxide, acetic acid, and amphotericin B.
BaoDi Dai +8 more
doaj +1 more source
Early redox activities modulate Xenopus tail regeneration. [PDF]
, 2018 Redox state sustained by reactive oxygen species (ROS) is crucial for regeneration; however, the interplay between oxygen (O2), ROS and hypoxia-inducible factors (HIF) remains elusive.
Ferreira, Fernando +4 more
core +2 more sources
Advanced Science, EarlyView.Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang +11 more
wiley +1 more source
Expression of HSP90 Gene in the Cryopreserved Bovine Spermatozoa
Scientific Papers Animal Science and Biotechnologies, 2023 Cryopreservation is a technique, commonly used for a long-term storage of male gametes as an effective way to preserve their longevity and vitality. During cryopreservation and following the thawing process, sperm cells are exposed to thermal stress ...
Filip Benko +4 more
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Heat-shock protein 90 promotes nuclear transport of herpes simplex virus 1 capsid protein by interacting with acetylated tubulin. [PDF]
PLoS ONE, 2014 Although it is known that inhibitors of heat shock protein 90 (Hsp90) can inhibit herpes simplex virus type 1 (HSV-1) infection, the role of Hsp90 in HSV-1 entry and the antiviral mechanisms of Hsp90 inhibitors remain unclear.
Meigong Zhong +10 more
doaj +1 more source
Biomimetic Cell Membrane‐Coated MOFs System for Targeted Cancer Therapy
Advanced Science, EarlyView.Biomimetic MOF‐based drug delivery nanoplatforms synthesized using liposomes or cell membranes as camouflage for multiple cancer therapeutics. ABSTRACT The integration of metal‐organic frameworks (MOFs) with cell membrane coatings has emerged as a revolutionary strategy to enhance the therapeutic efficacy of cancer nanomedicine.
Qilu Wu +6 more
wiley +1 more source
Drug Design, Development and Therapy, 2020 Liang-Jian Hong, Ai-Jun Chen, Feng-Zeng Li, Ke-Jun Chen, Sheng Fang Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, People’s Republic of ChinaCorrespondence: Sheng FangDepartment of ...
Hong LJ, Chen AJ, Li FZ, Chen KJ, Fang S
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