Results 71 to 80 of about 76,334 (253)

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast [PDF]

, 2012
Acknowledgments We thank Rebecca Shapiro for creating CaLC1819, CaLC1855 and CaLC1875, Gillian Milne for help with EM, Aaron Mitchell for generously providing the transposon insertion mutant library, Jesus Pla for generously providing the hog1 hst7 ...
Munro Carol, Louise Walker, Louise Walker (108683), Michelle D Leach, Walker Louise, Cowen, Leah E, Alistair J P Brown, Susan Budge, Michelle D. Leach (108675), Alistair J. P. Brown (108565), Budge, Susan, Walker, Louise, Carol Munro, Munro, Carol, Carol Munro (108688), Susan Budge (108680), Leah E. Cowen (108693), Leah E Cowen, Brown, Alistair J P, Leach, Michelle, Budge Susan, Brown Alistair J. P., Leach Michelle D., Cowen Leah E.   +23 more
core   +1 more source

Expression of HSP90 Gene in the Cryopreserved Bovine Spermatozoa

Scientific Papers Animal Science and Biotechnologies, 2023
Cryopreservation is a technique, commonly used for a long-term storage of male gametes as an effective way to preserve their longevity and vitality. During cryopreservation and following the thawing process, sperm cells are exposed to thermal stress ...
Filip Benko, Alexandra Geschwandtnerová, Jana Žiarovská, Norbert Lukáč, Eva Tvrdá   +4 more
doaj  

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

The HSP90 Inhibitor, 17-AAG, Influences the Activation and Proliferation of T Lymphocytes via AKT/GSK3β Signaling in MRL/lpr Mice

Drug Design, Development and Therapy, 2020
Liang-Jian Hong, Ai-Jun Chen, Feng-Zeng Li, Ke-Jun Chen, Sheng Fang Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, People’s Republic of ChinaCorrespondence: Sheng FangDepartment of ...
Hong LJ, Chen AJ, Li FZ, Chen KJ, Fang S
doaj  

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

The clickable activity-based probe of anti-apoptotic calenduloside E

Pharmaceutical Biology, 2019
Context: Calenduloside E (CE), one of the primary natural products found in Aralia elata (Miq.) Seem. (Araliaceae), possesses prominent anti-apoptotic potential.
Yu Tian, Shan Wang, Hai Shang, Wen-Qian Wang, Bao-Qi Wang, Xi Zhang, Xu-Dong Xu, Gui-Bo Sun, Xiao-Bo Sun   +8 more
doaj   +1 more source

Calcyclin Binding Protein/Siah-1 Interacting Protein Is a Hsp90 Binding Chaperone. [PDF]

PLoS ONE, 2016
The Hsp90 chaperone activity is tightly regulated by interaction with many co-chaperones. Since CacyBP/SIP shares some sequence homology with a known Hsp90 co-chaperone, Sgt1, in this work we performed a set of experiments in order to verify whether ...
Agnieszka Góral, Paweł Bieganowski, Wiktor Prus, Łucja Krzemień-Ojak, Beata Kądziołka, Hanna Fabczak, Anna Filipek   +6 more
doaj   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Unveiling the antiglioblastoma potential of harmicens, harmine and ferrocene hybrids

Acta Pharmaceutica
The poor prognosis of glioblastoma multiforme, inadequate treatment options, and growing drug resistance urge the need to find new effective agents. Due to the significant anti-cancer potential of harmicens, hybrid compounds which comprise harmine/β ...
Poje Goran, Šakić Davor, Marinović Marina, You Jiangyang, Tarpley Michael, Williams Kevin P., Golub Nikolina, Dernovšek Jaka, Tomašič Tihomir, Bešić Erim, Rajić Zrinka   +10 more
doaj   +1 more source