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Prognostic Significance of Heat Shock Proteins HSP70 and HSP90 in Endometrial Carcinomas
Cancer Detection <html_ent glyph="@amp;" ascii="&"/> Prevention, 1998Heat shock proteins HSP70 and HSP90 are sex steroid receptor-associated proteins, and HSP90 expression has reportedly been correlated with sex steroid receptor status in endometrial carcinomas. HSP70 is also known to associate with several oncogene products such as p53 protein, and expression of HSP70 has been reported to be a prognostic factor in ...
K, Nanbu +6 more
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Journal of Medicinal Chemistry, 2020
Hsp90 is one of the most important chaperones involved in regulating the maturation of more than 300 client proteins, many of which are closely associated with refractory diseases, including cancer, neurodegenerative diseases and viral infections ...
Li Li, Lei Wang, Q. You, Xiao-li Xu
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Hsp90 is one of the most important chaperones involved in regulating the maturation of more than 300 client proteins, many of which are closely associated with refractory diseases, including cancer, neurodegenerative diseases and viral infections ...
Li Li, Lei Wang, Q. You, Xiao-li Xu
semanticscholar +1 more source
Phylogenetic Analysis of Eukaryotes Using Heat-Shock Protein Hsp90
Journal of Molecular Evolution, 2003Most eukaryote molecular phylogenies have been based on small-subunit ribosomal RNA as its database includes the most species, but serious problems have been encountered that can make these trees misleading. More recent studies using concatenated protein sequences have increased the data per organism, reducing misleading signals from a single sequence,
Alexandra, Stechmann +1 more
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Clinical, Prognostic and Therapeutic Significance of Heat Shock Proteins in Cancer.
Current Drug Targets, 2017BACKGROUND Heat Shock Proteins (HSPs) constitute a group of proteins that play a crucial role in the process of protein folding. HSPs are also known to modulate a number of key apoptotic factors.
Jasleen Saini, P. Sharma
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Reactive Cysteines of the 90-kDa Heat Shock Protein, Hsp90
Archives of Biochemistry and Biophysics, 2000The 90-kDa heat shock protein (Hsp90) is the most abundant molecular chaperone of the eukaryotic cytoplasm. Its cysteine groups participate in the interactions of Hsp90 with the heme-regulated eIF-2alpha kinase and molybdate, a stabilizer of Hsp90-protein complexes. In our present studies we investigated the reactivity of the sulfhydryl groups of Hsp90.
G, Nardai +4 more
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Redefining the Phenotype of Heat Shock Protein 90 (Hsp90) Inhibitors
Chemistry – A European Journal, 2017AbstractThe phenotypes produced when cells are treated with the heat shock protein 90 (Hsp90) inhibitors AUY922 or 17‐AAG (classical inhibitors) are different to those produced when cells are knocked down with Hsp90α. Pull‐down assays using classical inhibitors suggest that these molecules bind to multiple targets other than Hsp90. Classical inhibitors
Yao Wang +2 more
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Chromatin Immunoprecipitation (ChIP) of Heat Shock Protein 90 (Hsp90)
2017Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is a widely used technique for genome-wide mapping of protein-DNA interactions and epigenetic marks in vivo. Recent studies have suggested an important role of heat shock protein 90 (Hsp90) at chromatin. This molecular chaperone assists other proteins to acquire their mature and functional
Yoveva, A., Sawarkar, R.
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Heat Shock Protein 90-antagonist Destabilizes Bcr-Abl/HSP90 Chaperone Complex
Leukemia & Lymphoma, 2002(2002). Heat Shock Protein 90-antagonist Destabilizes Bcr-Abl/HSP90 Chaperone Complex. Leukemia & Lymphoma: Vol. 43, No. 5, pp. 961-968.
Yukimasa, Shiotsu +2 more
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The glucose-regulated protein grp94 is related to heat shock protein hsp90
Journal of Molecular Biology, 1987We report the sequence of a cDNA clone that encodes the C-terminal half of the hamster 94 X 10(3) Mr glucose-regulated protein, grp94. The amino acid sequence of this protein is about 50% homologous to Drosophila hsp83 and yeast hsp90, suggesting that grp94 and hsp90 have similar functional properties.
P K, Sorger, H R, Pelham
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Allosteric Modulators of Heat Shock Protein 90 (HSP90)
2016Heat shock proteins (HSP) are a family of molecular chaperones that are the most conserved proteins present in both prokaryotes and eukaryotes. HSPs facilitate numerous events in cellular physiology including: protein recycling, transportation, migration, post-translational modification, and the regulation of signalling pathways.
Yen Chin Koay, Shelli McAlpine
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