Results 61 to 70 of about 33,737 (296)
Journal of Human Services, 2021 In the heart of the current COVID-19 outbreak, individuals are experiencing higher rates of mental and emotional distress associated with the unpredictability of a pandemic experience.
Brittany G. Suggs +5 more
doaj +1 more source
Forcing the Antitumor Effects of HSPs Using a Modulated Electric Field
, 2022 The role of Heat Shock Proteins (HSPs) is a “double-edged sword” with regards to tumors. The location and interactions of HSPs determine their pro- or antitumor activity.
Andras Szasz +3 more
core +1 more source
Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies
Advanced Science, EarlyView.In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang +4 more
wiley +1 more source
Roles of heat shock proteins in tumor immune microenvironment
Visualized Cancer MedicineHeat shock proteins (HSPs) are the most abundant molecular chaperones in cells, categorized based on function and molecular weight into HSP families, namely, HSP40, HSP70, HSP90, HSP110, and HSPB (heat shock protein B), et al.
Zhou Qin, Guan Xin-Yuan, Li Yan
doaj +1 more source
Heat shock proteins (HSPs) and diabetes
Proteini toplinskog šoka (eng. heat shock proteins, HSPs) visoko su očuvana obitelj proteina koje eksprimiraju sve stanice izložene okolišnom stresu i imaju različite funkcije. Razvrstani su u 7 glavnih obitelji prema molekulskoj masi: HSP10 (HSPE); mali
Rajić, Leonarda
core +2 more sources
AI‐Physics‐Experiment Trinity for Integrated Protein Dynamics Modeling
Advanced Science, EarlyView.This review unites experiments, physics‐based simulations, and AI as a synergistic triad for protein dynamics modeling. It highlights integrative strategies, resolves sampling and forcefield bottlenecks, and outlines challenges and future directions for accurate, interpretable conformational ensemble prediction.
Chen Shi +4 more
wiley +1 more source
, 2018 Las proteínas de choque térmico (HSPs) son inducidas por estrés celular y se expresan en niveles elevados en una amplia gama de tumores entre los que se incluyen el cáncer de seno, pulmón, próstata, colon, leucemias y estomago; esta sobre expresión está ...
Guerrero Fonseca, Carlos Arturo +1 more
core +2 more sources
TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain
Advanced Science, EarlyView.TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando +2 more
wiley +1 more source
Transcriptional Modulation of Heat-Shock Protein Gene Expression
Biochemistry Research International, 2011 Heat-shock proteins (Hsps) are molecular chaperones that are ubiquitously expressed but are also induced in cells exposed to stressful stimuli. Hsps have been implicated in the induction and propagation of several diseases.
Anastasis Stephanou, David S. Latchman
doaj +1 more source
Administrative Sciences, 2019 Owing to the contextual challenges, human service professionals (HSP) are creating social value (SV) for diverse vulnerable population groups through social innovation.
Monica Nandan +2 more
doaj +1 more source