Results 41 to 50 of about 29,028 (218)

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source

Conductive Hydroxyethyl Cellulose/Soy Protein Isolate/Polyaniline Conduits for Enhancing Peripheral Nerve Regeneration via Electrical Stimulation

Frontiers in Bioengineering and Biotechnology, 2020
Nerve regeneration remains a challenge to the treatment of peripheral nerve injury. Electrical stimulation (ES) is an assistant treatment to enhance recovery from peripheral nerve injury.
Ping Wu, Ping Wu, Yanan Zhao, Yanan Zhao, Yanan Zhao, Feixiang Chen, Feixiang Chen, Ao Xiao, Ao Xiao, Qiaoyue Du, Qiaoyue Du, Qi Dong, Qi Dong, Meifang Ke, Meifang Ke, Xiao Liang, Xiao Liang, Qing Zhou, Yun Chen, Yun Chen, Yun Chen   +20 more
doaj   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Iron‐Tannic Acid Hydrogel Mediated Mild Photothermal Therapy Combined With Ferroptosis Enhances Anti‐Tumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An injectable gelatin‐based tannic acid–iron hydrogel with mild photothermal therapy could not only induce immunogenic cell death, but also elicit ferroptosis of both tumor cells and tumor‐associated macrophages, resulting in DC maturation, T‐cell infiltration and down‐regulation of ferroptosis‐sensitive M2‐type TAMs levels.
Yuan Zhu, Xi Yu, Tao Wang, Wanyi Liu, Chang Lu, Jiani Zhong, Yujie He, Wei Li, Kunxi Zhang, Peihao Yin, Zeting Yuan   +10 more
wiley   +1 more source

Role of Heat Shock Proteins and Plasma Membrane on Thermotolerance in Saccharomyces cerevisiae-VS3 Strain [PDF]

Journal of Stress Physiology & Biochemistry, 2023
Aim: Study of HSPs synthesis after heat and cold shock and explanation of thermotolerance by the transport of HSPs to the plasma membrane. Methods and Results: Physical (cold and heat shock) and chemical (lignocaine) damage to plasma membrane was ...
Shaik Muzammil Pasha, Shaik Musfera, L. Venkateswar Rao, Chand Pasha   +3 more
doaj  

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Roles of heat shock proteins in tumor immune microenvironment

Visualized Cancer Medicine
Heat shock proteins (HSPs) are the most abundant molecular chaperones in cells, categorized based on function and molecular weight into HSP families, namely, HSP40, HSP70, HSP90, HSP110, and HSPB (heat shock protein B), et al.
Zhou Qin, Guan Xin-Yuan, Li Yan
doaj   +1 more source

Formation, Transformation, and Synergistic Interplay of Crystalline Orientation in Conjugated Polymers via Solution‐State Aggregation Control

Advanced Science, EarlyView.
Molecular engineering (i.e., tuning donors) and three film processing strategies (i.e., drop‐casting from different solvents, thermal and solvent vapor annealing, and blending) were synergistically utilized to tailor the solution‐state aggregation and thus the formation, transformation, and interplay of solid‐state crystalline orientation (face‐on and ...
Hao Zheng, Lixin Li, Yanan Guo, Bingjie Wu, Xuebing Luo, Hao Zhan, Yongjie Dong, Ze‐Fan Yao, Juan Peng, Jian Pei   +9 more
wiley   +1 more source

Helper, Healer, Mitigator: The Essential Role of the Human Services Provider in Current and Post-Pandemic Climates

Journal of Human Services, 2021
In the heart of the current COVID-19 outbreak, individuals are experiencing higher rates of mental and emotional distress associated with the unpredictability of a pandemic experience.
Brittany G. Suggs, Lauren B. Robins, Megan Cannedy, Alexandra C. Gantt, Dana L. Brookover, Kaprea F. Johnson   +5 more
doaj   +1 more source

Freestanding Hierarchical‐Porous BCZT Thin Films Enable Efficient Ultrasonic Energy Harvesting in Soft Tissue

Advanced Science, EarlyView.
Freestanding hierarchical‐porous BCZT thin films integrate a compliant porous surface with a dense piezoceramic backbone to balance mechanical reliability, voltage sensitivity, and acoustic coupling. The films enable stable wearable pulse‐wave monitoring and enhanced tissue‐coupled ultrasonic energy harvesting, offering a promising route toward soft ...
Zifan Li, Shengwei Gao, Wang Hong, Yuxin Chen, Yiyang Gu, Xu Wang, Chen Tang, Ying Hong, Xuemu Li, Xiaodong Yan, Yi Zheng, Yiming Liu, Junchen Liao, Biao Wang, Shiyuan Liu   +14 more
wiley   +1 more source