Results 21 to 30 of about 29,028 (218)

Different Heat Shock Proteins Bind α-Synuclein With Distinct Mechanisms and Synergistically Prevent Its Amyloid Aggregation

Frontiers in Neuroscience, 2019
α-Synuclein (α-Syn) forms pathological amyloid aggregates deposited in Lewy bodies and Lewy neurites in the brain of Parkinson’s disease (PD) patients.
Chunyu Jia, Chunyu Jia, Xiaojuan Ma, Xiaojuan Ma, Zhenying Liu, Zhenying Liu, Jinge Gu, Jinge Gu, Xiang Zhang, Xiang Zhang, Dan Li, Shengnan Zhang   +11 more
doaj   +1 more source

Traditional Chinese Medicine Targeting Heat Shock Proteins as Therapeutic Strategy for Heart Failure

Frontiers in Pharmacology, 2022
Heart failure (HF) is the terminal stage of multifarious heart diseases and is responsible for high hospitalization rates and mortality. Pathophysiological mechanisms of HF include cardiac hypertrophy, remodeling and fibrosis resulting from cell death ...
Yanchun Wang, Junxuan Wu, Dawei Wang, Rongyuan Yang, Qing Liu   +4 more
doaj   +1 more source

Comprehensive strategy of conduit guidance combined with VEGF producing Schwann cells accelerates peripheral nerve repair

Bioactive Materials, 2021
Peripheral nerve regeneration requires stepwise and well-organized establishment of microenvironment. Since local delivery of VEGF-A in peripheral nerve repair is expected to promote angiogenesis in the microenvironment and Schwann cells (SCs) play ...
Ping Wu, Zan Tong, Lihua Luo, Yanan Zhao, Feixiang Chen, Yinping Li, Céline Huselstein, Qifa Ye, Qingsong Ye, Yun Chen   +9 more
doaj   +1 more source

Heat Shock Proteins in Cancer

Pharmedicine Journal
Heat shock proteins (HSPs) are vital in the progression of cancer, aiding in the survival, proliferation, and metastasis of tumor cells. The overexpression of particular HSPs, such as HSP70 and HSP27, is often found in various malignancies, including ...
Seyma Sagır, Lütfi Tutar, Yusuf Tutar
doaj   +1 more source

Molecular insights into the heat shock proteins of the human parasitic blood fluke Schistosoma mansoni

Parasites & Vectors, 2022
Background Heat shock proteins (HSPs) are evolutionarily conserved proteins, produced by cells in response to hostile environmental conditions, that are vital to organism homeostasis. Here, we undertook the first detailed molecular bioinformatic analysis
Nancy A. Aguoru, Ruth S. Kirk, Anthony J. Walker   +2 more
doaj   +1 more source

Heat Shock Proteins in Cardiovascular Stress

Clinical Medicine Insights: Cardiology, 2008
Heat shock proteins (HSPs) are primarily induced in response to stress stimuli. In cardiovascular diseases, HSPs are expressed pronouncedly and act to protect the cardiac tissue by inhibition of cellular apoptopic mechanisms.
John Geraldine, Sandana Mala, Satoru Takeuchi   +2 more
doaj   +1 more source

Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy

Cells, 2019
Heat shock proteins (HSPs) constitute a large family of molecular chaperones classified by their molecular weights, and they include HSP27, HSP40, HSP60, HSP70, and HSP90.
Chul Won Yun, Hyung Joo Kim, Ji Ho Lim, Sang Hun Lee   +3 more
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Heat Shock Proteins as Immunomodulants

Molecules, 2018
Heat shock proteins (Hsps) are conserved molecules whose main role is to facilitate folding of other proteins. Most Hsps are generally stress-inducible as they play a particularly important cytoprotective role in cells exposed to stressful conditions ...
Tawanda Zininga, Lebogang Ramatsui, Addmore Shonhai   +2 more
doaj   +1 more source