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IDH1-R132H enhances oncolytic HSV-1 therapy by facilitating viral entry and immune activation in glioma. [PDF]
Panagioti E +17 more
europepmc +1 more source
Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated mitophagy. [PDF]
Fang Y +9 more
europepmc +1 more source
Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly. [PDF]
Yu Z +14 more
europepmc +1 more source
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SUN2 Modulates the Propagation of HSV-1
Journal of Virology, 2022The large size of herpesviruses prevents them from travelling across the nuclear pores, and they instead egress across the two nuclear membranes, generating short-lived enveloped perinuclear virions. This poses a challenge as the perinuclear space is smaller than the virions.
Kendra Cruz-Palomar +5 more
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Effect of Corilagin on anti-inflammation in HSV-1 encephalitis and HSV-1 infected microglias
European Journal of Pharmacology, 2010The aim of this explore is to study the anti-inflammatory effect of Corilagin in herpes simplex virus (HSV)-1 infected microglial cells and HSV-1 infected mouse brain. The cellular model was set with microglial cells stimulated by HSV-1 and divided respectively, into virus, astragalus polysaccharides (APS), Dexamethasone and Corilagin group.
Yuan-Jin, Guo +7 more
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Management of HSV-1 encephalitis due to reactivation of HSV-1 during late pregnancy
International Journal of Obstetric Anesthesia, 2012A previously healthy 31-year-old G4P2 woman at 33 weeks of gestation was admitted as an emergency with a pyrexia of 39°C, vomiting, headache and neck stiffness associated with photophobia, phonophobia and visual and auditory symptoms. There were no heraldic signs of eclampsia.
J, Pascal +9 more
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Immune Control of HSV-1 Latency
Viral Immunology, 2005A hallmark of the herpes family of viruses is their ability to cause recurrent disease. Upon primary infection, Herpes Simplex virus (HSV) establishes a latent infection in sensory neurons that persists for the life of the individual. Reactivation of these latent viral genomes with virion formation is the source of virus for most HSV recurrent disease.
Vilma, Decman +3 more
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