Results 1 to 10 of about 82,727 (264)
Expansion of the HSV-2-specific T cell repertoire in skin after immunotherapeutic HSV-2 vaccine. [PDF]
JCI InsightThe skin at the site of HSV-2 reactivation is enriched for HSV-2–specific T cells. To evaluate whether an immunotherapeutic vaccine could elicit skin-based memory T cells, we studied skin biopsies and HSV-2–reactive CD4 + T cells from PBMCs by T cell receptor (TCR) β chain (
Ford ES +19 more
europepmc +3 more sources
Epidemiological Characteristics of HSV-1 and HSV-2 in 177,599 Patients Based on PCR Testing in South Korea (2018–2022) [PDF]
PathogensHSV-1 is associated with oral lesions and non-sexual transmission; HSV-2 is primarily transmitted through sexual contact and causes genital infections.
Hyeong Ho Kim +4 more
doaj +2 more sources
BMJ Open, 2023 Objectives To assess the seroprevalence of herpes simplex virus (HSV) types 1 and 2 in patients infected with HIV in Nigeria.Design Cross-sectional design from January to June 2019.Setting Federal Teaching Hospital, Ebonyi State, Nigeria.Participants A ...
Euslar Nnenna Onu +10 more
doaj +1 more source
Recurrent Benign Lymphocytic Meningitis Due to HSV-2: A Case Report
Dr. Sulaiman Al Habib Medical Journal, 2023 Recurrent benign lymphocytic meningitis (RBLM) is an uncommon form of aseptic meningitis characterized by the recurrence of meningeal symptoms followed by spontaneous recovery.
Sirine Ahmad, Mohammed Alsaeed
doaj +1 more source
Pan-HSV-2 IgG antibody in vaccinated mice and guinea pigs correlates with protection against herpes simplex virus 2. [PDF]
PLoS ONE, 2013 We lack a correlate of immunity to herpes simplex virus 2 (HSV-2) that may be used to differentiate whether a HSV-2 vaccine elicits robust or anemic protection against genital herpes.
William P Halford +2 more
doaj +1 more source
HSV-2: in pursuit of a vaccine [PDF]
Journal of Clinical Investigation, 2011 Herpes simplex virus type 2 (HSV-2) is one of the most prevalent sexually transmitted infections worldwide. In addition to recurrent genital ulcers, HSV-2 causes neonatal herpes, and it is associated with a 3-fold increased risk for HIV acquisition. Although many HSV-2 vaccines have been studied in animal models, few have reached clinical trials, and ...
Christine, Johnston +2 more
openaire +2 more sources
The Ticking CLOCK of HSV-2 Pathology [PDF]
Journal of Investigative Dermatology, 2018 Herpes simplex virus type 2 (HSV-2) is the causative agent of genital herpes. Matsuzawa et al have demonstrated that, in a mouse model, HSV-2 pathology is influenced by the time infection occurs. Increased expression of the HSV-2 receptor Nectin-1 under the control of CLOCK coincided with an increase in viral titer suggesting that HSV-2 infection is ...
Bayliss, Rebecca J., Piguet, Vincent
openaire +2 more sources
Vaccines, 2020 The modified vaccinia virus Ankara (MVA), a severely attenuated strain of vaccinia virus, is a promising vector platform for viral-vectored vaccine development because of its attributes of efficient transgene expression and safety profile, among others ...
Vajini N. Atukorale +2 more
doaj +1 more source
Elsberg syndrome in HSV-2 infection
IDCases, 2023 Elsberg syndrome (ES) is a neuroinflammatory disease that causes acute or subacute lumbosacral radiculitis, with or without myelitis which accounts for approximately 5-10% of cauda equina syndrome and myelitis. We herein present a case of a middle-aged female who recently returned from the Dominican Republic and presented to the emergency room with ...
Omar Belfaqeeh +4 more
openaire +3 more sources
Drug Delivery, 2021 Chitosan glutamate (gCS) spray-dried microparticles appear promising carriers to overcome challenges associated with vaginal microbicide delivery. This study aimed at elucidating the penetration and mucoadhesive behavior of developed gCS multiunit ...
Emilia Szymańska +6 more
doaj +1 more source