Results 1 to 10 of about 80,157 (261)

Herpes Simplex Virus Mistyping due to HSV-1 × HSV-2 Interspecies Recombination in Viral Gene Encoding Glycoprotein B

Viruses, 2020
Human herpes simplex viruses (HSV) 1 and 2 are extremely common human pathogens with overlapping disease spectra. Infections due to HSV-1 and HSV-2 are distinguished in clinical settings using sequence-based “typing” assays.
Hong Xie, Amanda Casto, Christine Johnston   +2 more
exaly   +3 more sources

Expansion of the HSV-2-specific T cell repertoire in skin after immunotherapeutic HSV-2 vaccine. [PDF]

JCI Insight
The skin at the site of HSV-2 reactivation is enriched for HSV-2–specific T cells. To evaluate whether an immunotherapeutic vaccine could elicit skin-based memory T cells, we studied skin biopsies and HSV-2–reactive CD4 + T cells from PBMCs by T cell receptor (TCR) β chain (
Ford ES, Li AZ, Laing KJ, Dong L, Diem K, Jing L, Mayer-Blackwell K, Basu K, Ott M, Tartaglia J, Gurunathan S, Reid JL, Ecsedi M, Chapuis AG, Huang ML, Magaret AS, Johnston C, Zhu J, Koelle DM, Corey L.   +19 more
europepmc   +3 more sources

Antibody to HSV gD peptide induced by vaccination does not protect against HSV-2 infection in HSV-2 seronegative women. [PDF]

PLoS ONE, 2017
BACKGROUND:In the HIV-1 vaccine trial RV144, ALVAC-HIV prime with an AIDSVAX® B/E boost reduced HIV-1 acquisition by 31% at 42 months post first vaccination.
Peter B Gilbert, Jean-Louis Excler, Georgia D Tomaras, Lindsay N Carpp, Barton F Haynes, Hua-Xin Liao, David C Montefiori, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Jaranit Kaewkungwal, Gustavo H Kijak, Sodsai Tovanabutra, Donald P Francis, Carter Lee, Faruk Sinangil, Phillip W Berman, Nakorn Premsri, Prayura Kunasol, Robert J O'Connell, Nelson L Michael, Merlin L Robb, Rhoda Morrow, Lawrence Corey, Jerome H Kim   +24 more
doaj   +5 more sources

Analysis of HSV1/2 Infection Reveals an Association between HSV-2 Reactivation and Pregnancy [PDF]

Viruses
The herpes simplex viruses consist of the strains, HSV-1 and HSV-2, which are prevalent worldwide and lack a definitive cure. We aimed to explore the specific characteristics of HSV 1 and 2 infections, such as differences between gender assigned at birth,
Sara Dovrat, Adar Shabat, Anat Yahav-Dovrat, Zvia Soufiev, Ella Mendelson, Ela Kashi-Zagdoun, Galia Rahav   +6 more
doaj   +2 more sources

Epidemiological Characteristics of HSV-1 and HSV-2 in 177,599 Patients Based on PCR Testing in South Korea (2018–2022) [PDF]

Pathogens
HSV-1 is associated with oral lesions and non-sexual transmission; HSV-2 is primarily transmitted through sexual contact and causes genital infections.
Hyeong Ho Kim, Sung Hun Jang, Jeong Su Han, Jae-Sik Jeon, Jae Kyung Kim   +4 more
doaj   +2 more sources

Seroprevalence of antibodies to herpes simplex virus 1 and 2 in patients with HIV positive from Ebonyi State, Nigeria: a cross-sectional study

BMJ Open, 2023
Objectives To assess the seroprevalence of herpes simplex virus (HSV) types 1 and 2 in patients infected with HIV in Nigeria.Design Cross-sectional design from January to June 2019.Setting Federal Teaching Hospital, Ebonyi State, Nigeria.Participants A ...
Euslar Nnenna Onu, Uchechukwu Onyeukwu Ekuma, Hawraa K Judi, Ogbonnaya Ogbu, Nworie Okoro, Gloria C Ajugwo, Sousan Akrami, Chukwudum S Okoli, Chioma Ngozi Anyanwu, Morteza Saki, Peter Anyigor Edeh   +10 more
doaj   +1 more source

HSV-2: in pursuit of a vaccine [PDF]

Journal of Clinical Investigation, 2011
Herpes simplex virus type 2 (HSV-2) is one of the most prevalent sexually transmitted infections worldwide. In addition to recurrent genital ulcers, HSV-2 causes neonatal herpes, and it is associated with a 3-fold increased risk for HIV acquisition. Although many HSV-2 vaccines have been studied in animal models, few have reached clinical trials, and ...
Christine, Johnston, David M, Koelle, Anna, Wald   +2 more
openaire   +2 more sources

Pan-HSV-2 IgG antibody in vaccinated mice and guinea pigs correlates with protection against herpes simplex virus 2. [PDF]

PLoS ONE, 2013
We lack a correlate of immunity to herpes simplex virus 2 (HSV-2) that may be used to differentiate whether a HSV-2 vaccine elicits robust or anemic protection against genital herpes.
William P Halford, Joshua Geltz, Edward Gershburg   +2 more
doaj   +1 more source

The Ticking CLOCK of HSV-2 Pathology [PDF]

Journal of Investigative Dermatology, 2018
Herpes simplex virus type 2 (HSV-2) is the causative agent of genital herpes. Matsuzawa et al have demonstrated that, in a mouse model, HSV-2 pathology is influenced by the time infection occurs. Increased expression of the HSV-2 receptor Nectin-1 under the control of CLOCK coincided with an increase in viral titer suggesting that HSV-2 infection is ...
Bayliss, Rebecca J., Piguet, Vincent
openaire   +2 more sources

Recurrent Benign Lymphocytic Meningitis Due to HSV-2: A Case Report

Dr. Sulaiman Al Habib Medical Journal, 2023
Recurrent benign lymphocytic meningitis (RBLM) is an uncommon form of aseptic meningitis characterized by the recurrence of meningeal symptoms followed by spontaneous recovery.
Sirine Ahmad, Mohammed Alsaeed
doaj   +1 more source