Viruses, 2023 The thymidine kinase (TK) and DNA polymerase (pol) genes of the herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) are two important genes involved in antiviral resistance.
Jungwon Hyun +7 more
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Vaginal HSV-2 Infection and Tissue Analysis [PDF]
BIO-PROTOCOL, 2017 The vaginal murine HSV-2 infection model is very useful in studying mucosal immunity against HSV-2 ( Overall et al., 1975 ; Renis et al., 1976 ; Parr and Parr, 2003). Histologically, the vagina of Depo-Provera-treated mice is lined by a single layer of mucus secreting columnar epithelial cells overlying two to three layers of proliferative cells.
Marie Iversen +2 more
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Herpes Simplex Virus Type-2 Paralyzes the Function of Monocyte-Derived Dendritic Cells
Viruses, 2020 Herpes simplex viruses not only infect a variety of different cell types, including dendritic cells (DCs), but also modulate important cellular functions in benefit of the virus. Given the relevance of directed immune cell migration during the initiation
Linda Grosche +7 more
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Invasive Obstetric Procedures and Cesarean Sections in Women With Known Herpes Simplex Virus Status During Pregnancy. [PDF]
, 2017 BackgroundNeonatal herpes is a potentially devastating infection that results from acquisition of herpes simplex virus (HSV) type 1 or 2 from the maternal genital tract at the time of vaginal delivery.
Drolette, Linda +7 more
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Antibodies Are Required for Complete Vaccine-Induced Protection against Herpes Simplex Virus 2.
PLoS ONE, 2015 Herpes simplex virus 2 (HSV-2) 0ΔNLS is a live HSV-2 ICP0- mutant vaccine strain that is profoundly attenuated in vivo due to its interferon-hypersensitivity.
William P Halford +3 more
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HSV-2 glycoprotein J promotes viral protein expression and virus spread. [PDF]
, 2018 HSV-2 spread is predominantly dependent on cell-to-cell contact. However, the underlying mechanisms remain to be determined. Here we demonstrate that HSV-2 gJ, which was previously assigned no specific function, promotes HSV-2 cell-to-cell spread and ...
Guan, X +8 more
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Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations
BMC Infectious Diseases, 2002 Background The thymidine kinase (tk) mutagenesis assay is often utilized to determine the frequency of herpes simplex virus (HSV) replication-mediated mutations. Using this assay, clinical and laboratory HSV-2 isolates were shown to have a 10- to 80-fold
Leary Jeffry J +8 more
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Virus-specific immune memory at peripheral sites of herpes simplex virus type 2 (HSV-2) infection in guinea pigs. [PDF]
PLoS ONE, 2014 Despite its importance in modulating HSV-2 pathogenesis, the nature of tissue-resident immune memory to HSV-2 is not completely understood. We used genital HSV-2 infection of guinea pigs to assess the type and location of HSV-specific memory cells at ...
Jingya Xia +4 more
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Herpes Simplex Virus Type 2 Immediate Early Protein ICP27 Inhibits IFN-β Production in Mucosal Epithelial Cells by Antagonizing IRF3 Activation. [PDF]
, 2019 Herpes simplex virus type 2 (HSV-2) is the main cause of genital herpes and infections are common in the lower genital tract. Although neuronal and immune cells can be infected, epithelial cells, and keratinocytes are the primary HSV-2 target cells.
Ming Fu +7 more
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PLoS ONE, 2010 Herpes simplex virus 1 (HSV-1) ICP0(-) mutants are interferon-sensitive, avirulent, and elicit protective immunity against HSV-1 (Virol J, 2006, 3:44).
William P Halford +2 more
doaj +1 more source