Results 31 to 40 of about 112,416,099 (307)

Fatal fulminant HSV-2 myocarditis: A complicated presentation [PDF]

International Journal of Infectious Diseases, 2022
Herpes simplex virus type 2 (HSV-2) infection is the leading cause of genital lesions. Infrequently HSV-2 primary infection can spread and involve other tissue and organs, however in immunocompetent individuals extra-genital complications are rare findings.
Daniele Colombo, Marco Albore, Franca Del Nonno, Giorgio Bolino, Mario D'Ambrosio, Alessandra Salvi, Camilla Cecannecchia, Laura Falasca   +7 more
openaire   +3 more sources

Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations

BMC Infectious Diseases, 2002
Background The thymidine kinase (tk) mutagenesis assay is often utilized to determine the frequency of herpes simplex virus (HSV) replication-mediated mutations. Using this assay, clinical and laboratory HSV-2 isolates were shown to have a 10- to 80-fold
Leary Jeffry J, Halsey Wendy M, Bartus Joan O, Wittrock Robert J, Nguyen Tammy T, Quail Matthew R, Duffy Karen E, Bacon Teresa H, Sarisky Robert T   +8 more
doaj   +1 more source

Melatonin as an immunomodulator in combined therapy of herpesvirus skin diseases associated with HIV

Journal of V. N. Karazin Kharkiv National University: Series Medicine, 2021
Introduction. Highly active antiretroviral therapy is the current standard of care for patients with HIV/AIDS. Although antiretroviral therapy is etiotropic, quite effective in reducing viral load, recurrent opportunistic infections can lead to adverse ...
Diana Dorosh, Tetiana Liadova, Popov Mykola, Iryna Kadygrob, Mykola Shustval, Roman Malantschuk   +5 more
doaj   +1 more source

Antibodies Are Required for Complete Vaccine-Induced Protection against Herpes Simplex Virus 2.

PLoS ONE, 2015
Herpes simplex virus 2 (HSV-2) 0ΔNLS is a live HSV-2 ICP0- mutant vaccine strain that is profoundly attenuated in vivo due to its interferon-hypersensitivity.
William P Halford, Joshua Geltz, Ronald J Messer, Kim J Hasenkrug   +3 more
doaj   +1 more source

Herpes simplex virus 2 ICP0 mutant viruses are avirulent and immunogenic: implications for a genital herpes vaccine.

PLoS ONE, 2010
Herpes simplex virus 1 (HSV-1) ICP0(-) mutants are interferon-sensitive, avirulent, and elicit protective immunity against HSV-1 (Virol J, 2006, 3:44).
William P Halford, Ringo Püschel, Brandon Rakowski   +2 more
doaj   +1 more source

Disseminated HSV-2 presenting with relapsing encephalomyelitis [PDF]

Neurology Clinical Practice, 2016
A previously healthy 39-year-old woman presented with 3 weeks of progressive leg numbness. Examination showed mild bilateral iliopsoas weakness and patchy leg numbness. She was admitted, and spinal MRI revealed T2 enhancing thoracic lesions, nonenhancing cervical cord lesions (figure, A), and subtle pial and cauda equina enhancement (figure, B).
Clotilde, Hainline, Dominique, Rosales, Purvi, Parikh, Eddie, Louie, Jonathan, Howard, Nina, Kim, Steven L, Galetta   +6 more
openaire   +2 more sources

Expansion of the HSV-2-specific T cell repertoire in skin after immunotherapeutic HSV-2 vaccine. [PDF]

JCI Insight
The skin at the site of HSV-2 reactivation is enriched for HSV-2–specific T cells. To evaluate whether an immunotherapeutic vaccine could elicit skin-based memory T cells, we studied skin biopsies and HSV-2–reactive CD4 + T cells from PBMCs by T cell receptor (TCR) β chain (
Ford ES, Li AZ, Laing KJ, Dong L, Diem K, Jing L, Mayer-Blackwell K, Basu K, Ott M, Tartaglia J, Gurunathan S, Reid JL, Ecsedi M, Chapuis AG, Huang ML, Magaret AS, Johnston C, Zhu J, Koelle DM, Corey L.   +19 more
europepmc   +3 more sources

Detection of Viruses associated with Herpes Labialis Patients in Babylon Province Pre and Post Treatment with Low Power Laser Therapy (Diode Laser)

Medical Journal of Babylon
Background:The secondary or recurrent herpetic infections (RHIs) are caused by herpes simplex virus (HSV) type-1 and type-2. low-power laser therapy 940 nm may consider one of the best and most optimistic and optional local therapeutic and biological ...
Ahmed Jaber Aboob, Ali Mihsen Hussein Alyassiri, Younis Abdulridha Alkhafaji   +2 more
doaj   +1 more source

Correlates of HIV-1 genital shedding in Tanzanian women. [PDF]

, 2011
BACKGROUND: Understanding the correlates of HIV shedding is important to inform strategies to reduce HIV infectiousness. We examined correlates of genital HIV-1 RNA in women who were seropositive for both herpes simplex virus (HSV)-2 and HIV-1 and who ...
Clare Tanton, David A. Ross, Watson-Jones Deborah, Weiss, Helen A, Watson-Jones, Deborah, Helen A Weiss, Richard J. Hayes, Laurent Belec, Tanton, Clare, Le Goff, Jerome, Hayes, Richard J, Deborah Watson-Jones, Le Goff Jerome, Belec Laurent, Baisley, Kathy, Changalucha John, Weiss Helen A., Everett Dean, Ross, David A, Everett, Dean, David A Ross, Kathy Baisley, Changalucha, John, Mary Rusizoka, Jerome Le Goff, Helen A. Weiss, John Changalucha, Tanton Clare, Dean Everett, Richard J Hayes, Baisley Kathy, Ross David A., Rusizoka, Mary, Rusizoka Mary, Hayes Richard J., Belec, Laurent   +35 more
core   +1 more source

Inactivating and inhibitory activity of dry ethanol extracts of wormwood (Artemisia spp.) on herpes simplex virus of the 2 type in vitro

Юг России: экология, развитие
Aim. In vitro assessment of the inactivating and inhibitory activity of dry ethanol extracts of various wormwood species (Artemisia spp.) native to the Novosibirsk region and Altai Republic on the replication of Herpes simplex virus type 2 (HSV-2 ...
E. I. Каzachinskaia, V. V. Velichko, V. D. Romanova, D. S. Kruglov, D. L. Prokusheva, A. A. Chepurnov, Yu. V. Коnonova, L. Fu, Sh. Shao, M. A. Gulyaeva, A. M. Shestopalov   +10 more
doaj   +1 more source