Results 11 to 20 of about 112,416,099 (307)
HSV-2- and HIV-1- permissive cell lines co-infected by HSV-2 and HIV-1 co-replicate HSV-2 and HIV-1 without production of HSV-2/HIV-1 pseudotype particles. [PDF]
Virology journal, 2007 Herpes simplex virus type 2 (HSV-2) is a major cofactor of human immunodeficiency virus type 1 (HIV-1) sexual acquisition and transmission. In the present study, we investigated whether HIV-1 and HSV-2 may interact at the cellular level by forming HIV-1 hybrid virions pseudotyped with HSV-2 envelope glycoproteins, as was previously reported for HSV ...
Bélec Laurent +7 more
openaire +4 more sources
LAT region factors mediating differential neuronal tropism of HSV-1 and HSV-2 do not act in trans. [PDF]
PLoS ONE, 2012 After HSV infection, some trigeminal ganglion neurons support productive cycle gene expression, while in other neurons the virus establishes a latent infection.
Andrea S Bertke +8 more
doaj +3 more sources
Negative epidemiological association between HSV-1 and HSV-2 infections [PDF]
Heliyon, 2019 Objectives: Existing evidence on an epidemiological association between herpes simplex virus (HSV) type 1 and type 2 infections remains conflicting and inconclusive.
Gheyath K. Nasrallah +2 more
doaj +2 more sources
HSV-2: in pursuit of a vaccine [PDF]
Journal of Clinical Investigation, 2011 Herpes simplex virus type 2 (HSV-2) is one of the most prevalent sexually transmitted infections worldwide. In addition to recurrent genital ulcers, HSV-2 causes neonatal herpes, and it is associated with a 3-fold increased risk for HIV acquisition. Although many HSV-2 vaccines have been studied in animal models, few have reached clinical trials, and ...
Christine, Johnston +2 more
openaire +2 more sources
The Ticking CLOCK of HSV-2 Pathology [PDF]
Journal of Investigative Dermatology, 2018 Herpes simplex virus type 2 (HSV-2) is the causative agent of genital herpes. Matsuzawa et al have demonstrated that, in a mouse model, HSV-2 pathology is influenced by the time infection occurs. Increased expression of the HSV-2 receptor Nectin-1 under the control of CLOCK coincided with an increase in viral titer suggesting that HSV-2 infection is ...
Bayliss, Rebecca J., Piguet, Vincent
openaire +2 more sources
Elsberg syndrome in HSV-2 infection
IDCases, 2023 Elsberg syndrome (ES) is a neuroinflammatory disease that causes acute or subacute lumbosacral radiculitis, with or without myelitis which accounts for approximately 5-10% of cauda equina syndrome and myelitis. We herein present a case of a middle-aged female who recently returned from the Dominican Republic and presented to the emergency room with ...
Omar Belfaqeeh +4 more
openaire +3 more sources
Expansion of the HSV-2-specific T cell repertoire in skin after immunotherapeutic HSV-2 vaccine [PDF]
, 2022 ABSTRACT The skin at the site of HSV-2 reactivation is enriched for HSV-2-specific T cells. To evaluate whether an immunotherapeutic vaccine could elicit skin-based memory T cells, we studied skin biopsies and HSV-2-reactive CD4 + T cells from peripheral blood mononuclear cells ...
Ford, Emily S. +18 more
openaire +2 more sources
Dynamics of HSV-2 infection with a therapeutic vaccine [PDF]
Heliyon, 2020 Herpes-Simplex Virus type 2 (HSV-2) is a lifelong infection, which has infected over 400 million individuals aged 15-49 years, worldwide. While the disease can be treated with episodic and suppressive antiviral drugs to reduce the rate of recurrence (i.e., symptomatic disease) and viral shedding, none of the currently available therapies can clear the ...
Ezio Venturino +2 more
openaire +3 more sources
HSV-2 parameter values and assumptions.
, 2022 HSV-2 parameter values and assumptions.
Christine Johnston (375038) +4 more
core +1 more source
Effect of genital herpes on cervicovaginal HIV shedding in women co-infected with HIV AND HSV-2 in Tanzania. [PDF]
, 2013 To compare the presence and quantity of cervicovaginal HIV among HIV seropositive women with clinical herpes, subclinical HSV-2 infection and without HSV-2 infection respectively; to evaluate the association between cervicovaginal HIV and HSV shedding ...
Riedner, Gabriele +32 more
core +1 more source