Results 11 to 20 of about 82,727 (264)
Viruses, 2023 Adolescents and young people are particularly vulnerable to contracting STIs, including HSV-2; furthermore, vaginal shedding of HSV-2 during pregnancy can cause vertical transmission and neonatal herpes.
Julio Cesar Muñiz-Salgado +6 more
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Expansion of the HSV-2-specific T cell repertoire in skin after immunotherapeutic HSV-2 vaccine [PDF]
, 2022 ABSTRACT The skin at the site of HSV-2 reactivation is enriched for HSV-2-specific T cells. To evaluate whether an immunotherapeutic vaccine could elicit skin-based memory T cells, we studied skin biopsies and HSV-2-reactive CD4 + T cells from peripheral blood mononuclear cells ...
Ford, Emily S. +18 more
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Dynamics of HSV-2 infection with a therapeutic vaccine [PDF]
Heliyon, 2020 Herpes-Simplex Virus type 2 (HSV-2) is a lifelong infection, which has infected over 400 million individuals aged 15-49 years, worldwide. While the disease can be treated with episodic and suppressive antiviral drugs to reduce the rate of recurrence (i.e., symptomatic disease) and viral shedding, none of the currently available therapies can clear the ...
Ezio Venturino +2 more
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Human Vaccines & Immunotherapeutics, 2020 A vaccine to prevent genital herpes is an unmet public health need. We previously reported that a trivalent vaccine containing herpes simplex virus type 2 (HSV-2) glycoproteins C, D, and E (gC2, gD2, gE2) produced in baculovirus and administered with CpG/
Kevin Egan +4 more
doaj +1 more source
Herpes Simplex Virus Type-2 Paralyzes the Function of Monocyte-Derived Dendritic Cells
Viruses, 2020 Herpes simplex viruses not only infect a variety of different cell types, including dendritic cells (DCs), but also modulate important cellular functions in benefit of the virus. Given the relevance of directed immune cell migration during the initiation
Linda Grosche +7 more
doaj +1 more source
Viruses, 2020 Human herpes simplex viruses (HSV) 1 and 2 are extremely common human pathogens with overlapping disease spectra. Infections due to HSV-1 and HSV-2 are distinguished in clinical settings using sequence-based “typing” assays.
Amanda M. Casto +6 more
doaj +1 more source
Seroprevalence of herpes simplex virus type 1 and type 2 among the migrant workers in Qatar
Virology Journal, 2023 Background Limited data exists on herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infections in migrant populations. This study investigated HSV-1 and HSV-2 seroprevalences and associations among craft and manual workers (CMWs) in Qatar who ...
Gheyath K. Nasrallah +47 more
doaj +1 more source
Immunization with Herpes Simplex Virus 2 (HSV-2) Genes plus Inactivated HSV-2 Is Highly Protective against Acute and Recurrent HSV-2 Disease [PDF]
Journal of Virology, 2011 ABSTRACTTo date, no vaccine that is safe and effective against herpes simplex virus 2 (HSV-2) disease has been licensed. In this study, we evaluated a DNA prime-formalin-inactivated-HSV-2 (FI-HSV2) boost vaccine approach in the guinea pig model of acute and recurrent HSV-2 genital disease.
Christopher S, Morello +3 more
openaire +2 more sources
Kurdistan Journal of Applied Research, 2018 Among many viral causes of miscarriage, maternal infections caused by herpes simplex virus type -1 (HSV-1) and Herpes simplex virus type-2 (HSV-2) infections are important causes.
Zainab A. Hamid +2 more
doaj +3 more sources
Revista de Saúde Pública, 2010 OBJETIVO: Estimar a soroprevalência de anticorpos por vírus herpes simples (HSV-1 e HSV-2) e analisar fatores associados no Brasil. MÉTODOS: Estudo transversal realizado entre 1996 e 1997 em 1.090 indivíduos com idade entre um e 40 anos da população ...
Sue Ann Costa Clemens +1 more
doaj +1 more source