Results 11 to 20 of about 80,157 (261)
Elsberg syndrome in HSV-2 infection
IDCases, 2023 Elsberg syndrome (ES) is a neuroinflammatory disease that causes acute or subacute lumbosacral radiculitis, with or without myelitis which accounts for approximately 5-10% of cauda equina syndrome and myelitis. We herein present a case of a middle-aged female who recently returned from the Dominican Republic and presented to the emergency room with ...
Omar Belfaqeeh +4 more
openaire +3 more sources
Vaccines, 2020 The modified vaccinia virus Ankara (MVA), a severely attenuated strain of vaccinia virus, is a promising vector platform for viral-vectored vaccine development because of its attributes of efficient transgene expression and safety profile, among others ...
Vajini N. Atukorale +2 more
doaj +1 more source
Expansion of the HSV-2-specific T cell repertoire in skin after immunotherapeutic HSV-2 vaccine [PDF]
, 2022 ABSTRACT The skin at the site of HSV-2 reactivation is enriched for HSV-2-specific T cells. To evaluate whether an immunotherapeutic vaccine could elicit skin-based memory T cells, we studied skin biopsies and HSV-2-reactive CD4 + T cells from peripheral blood mononuclear cells ...
Ford, Emily S. +18 more
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Viruses, 2023 Adolescents and young people are particularly vulnerable to contracting STIs, including HSV-2; furthermore, vaginal shedding of HSV-2 during pregnancy can cause vertical transmission and neonatal herpes.
Julio Cesar Muñiz-Salgado +6 more
doaj +1 more source
Dynamics of HSV-2 infection with a therapeutic vaccine [PDF]
Heliyon, 2020 Herpes-Simplex Virus type 2 (HSV-2) is a lifelong infection, which has infected over 400 million individuals aged 15-49 years, worldwide. While the disease can be treated with episodic and suppressive antiviral drugs to reduce the rate of recurrence (i.e., symptomatic disease) and viral shedding, none of the currently available therapies can clear the ...
Ezio Venturino +2 more
openaire +3 more sources
Drug Delivery, 2021 Chitosan glutamate (gCS) spray-dried microparticles appear promising carriers to overcome challenges associated with vaginal microbicide delivery. This study aimed at elucidating the penetration and mucoadhesive behavior of developed gCS multiunit ...
Emilia Szymańska +6 more
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2020 A vaccine to prevent genital herpes is an unmet public health need. We previously reported that a trivalent vaccine containing herpes simplex virus type 2 (HSV-2) glycoproteins C, D, and E (gC2, gD2, gE2) produced in baculovirus and administered with CpG/
Kevin Egan +4 more
doaj +1 more source
Immunization with Herpes Simplex Virus 2 (HSV-2) Genes plus Inactivated HSV-2 Is Highly Protective against Acute and Recurrent HSV-2 Disease [PDF]
Journal of Virology, 2011 ABSTRACTTo date, no vaccine that is safe and effective against herpes simplex virus 2 (HSV-2) disease has been licensed. In this study, we evaluated a DNA prime-formalin-inactivated-HSV-2 (FI-HSV2) boost vaccine approach in the guinea pig model of acute and recurrent HSV-2 genital disease.
Christopher S, Morello +3 more
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Herpes Simplex Virus Type-2 Paralyzes the Function of Monocyte-Derived Dendritic Cells
Viruses, 2020 Herpes simplex viruses not only infect a variety of different cell types, including dendritic cells (DCs), but also modulate important cellular functions in benefit of the virus. Given the relevance of directed immune cell migration during the initiation
Linda Grosche +7 more
doaj +1 more source
Seroprevalence of herpes simplex virus type 1 and type 2 among the migrant workers in Qatar
Virology Journal, 2023 Background Limited data exists on herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infections in migrant populations. This study investigated HSV-1 and HSV-2 seroprevalences and associations among craft and manual workers (CMWs) in Qatar who ...
Gheyath K. Nasrallah +47 more
doaj +1 more source