Results 11 to 20 of about 95,433 (302)
Fatal fulminant HSV-2 myocarditis: A complicated presentation [PDF]
International Journal of Infectious Diseases, 2022 Herpes simplex virus type 2 (HSV-2) infection is the leading cause of genital lesions. Infrequently HSV-2 primary infection can spread and involve other tissue and organs, however in immunocompetent individuals extra-genital complications are rare findings.
Daniele Colombo +7 more
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Pan-HSV-2 IgG antibody in vaccinated mice and guinea pigs correlates with protection against herpes simplex virus 2. [PDF]
PLoS ONE, 2013 We lack a correlate of immunity to herpes simplex virus 2 (HSV-2) that may be used to differentiate whether a HSV-2 vaccine elicits robust or anemic protection against genital herpes.
William P Halford +2 more
doaj +1 more source
The Ticking CLOCK of HSV-2 Pathology [PDF]
Journal of Investigative Dermatology, 2018 Herpes simplex virus type 2 (HSV-2) is the causative agent of genital herpes. Matsuzawa et al have demonstrated that, in a mouse model, HSV-2 pathology is influenced by the time infection occurs. Increased expression of the HSV-2 receptor Nectin-1 under the control of CLOCK coincided with an increase in viral titer suggesting that HSV-2 infection is ...
Bayliss, Rebecca J., Piguet, Vincent
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Immunization with Herpes Simplex Virus 2 (HSV-2) Genes plus Inactivated HSV-2 Is Highly Protective against Acute and Recurrent HSV-2 Disease [PDF]
Journal of Virology, 2011 ABSTRACTTo date, no vaccine that is safe and effective against herpes simplex virus 2 (HSV-2) disease has been licensed. In this study, we evaluated a DNA prime-formalin-inactivated-HSV-2 (FI-HSV2) boost vaccine approach in the guinea pig model of acute and recurrent HSV-2 genital disease.
Christopher S, Morello +3 more
openaire +2 more sources
HSV-2 Infection of Human Genital Epithelial Cells Upregulates TLR9 Expression Through the SP1/JNK Signaling Pathway [PDF]
, 2020 It is known that herpes simplex virus type 2 (HSV-2) triggers the activation of Toll-like receptor (TLR) 9 signaling pathway and the consequent production of antiviral cytokines in dendritic cells.
Barreto, M +11 more
core +1 more source
Vaccines, 2020 The modified vaccinia virus Ankara (MVA), a severely attenuated strain of vaccinia virus, is a promising vector platform for viral-vectored vaccine development because of its attributes of efficient transgene expression and safety profile, among others ...
Vajini N. Atukorale +2 more
doaj +1 more source
Viruses, 2023 Adolescents and young people are particularly vulnerable to contracting STIs, including HSV-2; furthermore, vaginal shedding of HSV-2 during pregnancy can cause vertical transmission and neonatal herpes.
Julio Cesar Muñiz-Salgado +6 more
doaj +1 more source
Expansion of the HSV-2-specific T cell repertoire in skin after immunotherapeutic HSV-2 vaccine [PDF]
, 2022 ABSTRACTThe skin at the site of HSV-2 reactivation is enriched for HSV-2-specific T cells. To evaluate whether an immunotherapeutic vaccine could elicit skin-based memory T cells, we studied skin biopsies and HSV-2-reactive CD4+T cells from peripheral blood mononuclear cells (PBMCs) by T cell receptor β (TRB) sequencing before and after vaccination ...
Ford, Emily S. +18 more
openaire +2 more sources
Recurrent Benign Lymphocytic Meningitis Due to HSV-2: A Case Report
Dr. Sulaiman Al Habib Medical Journal, 2023 Recurrent benign lymphocytic meningitis (RBLM) is an uncommon form of aseptic meningitis characterized by the recurrence of meningeal symptoms followed by spontaneous recovery.
Sirine Ahmad, Mohammed Alsaeed
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2020 A vaccine to prevent genital herpes is an unmet public health need. We previously reported that a trivalent vaccine containing herpes simplex virus type 2 (HSV-2) glycoproteins C, D, and E (gC2, gD2, gE2) produced in baculovirus and administered with CpG/
Kevin Egan +4 more
doaj +1 more source