Viruses, 2023 The thymidine kinase (TK) and DNA polymerase (pol) genes of the herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) are two important genes involved in antiviral resistance.
Jungwon Hyun +7 more
doaj +1 more source
Seroprevalence, predictors and estimated incidence of maternal and neonatal Herpes Simplex Virus Type 2 infection in semi-urban women in Kilifi, Kenya [PDF]
, 2011 Background: Herpes Simplex Virus type 2 (HSV-2) has public health importance as a leading cause of genital ulcers, a co-factor in HIV-1 acquisition and transmission and as a cause of neonatal herpes infections.
Awuondo Ken +35 more
core +1 more source
Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations
BMC Infectious Diseases, 2002 Background The thymidine kinase (tk) mutagenesis assay is often utilized to determine the frequency of herpes simplex virus (HSV) replication-mediated mutations. Using this assay, clinical and laboratory HSV-2 isolates were shown to have a 10- to 80-fold
Leary Jeffry J +8 more
doaj +1 more source
Fatal fulminant HSV-2 myocarditis: A complicated presentation [PDF]
International Journal of Infectious Diseases, 2022 Herpes simplex virus type 2 (HSV-2) infection is the leading cause of genital lesions. Infrequently HSV-2 primary infection can spread and involve other tissue and organs, however in immunocompetent individuals extra-genital complications are rare findings.
Daniele Colombo +7 more
openaire +3 more sources
Antibodies Are Required for Complete Vaccine-Induced Protection against Herpes Simplex Virus 2.
PLoS ONE, 2015 Herpes simplex virus 2 (HSV-2) 0ΔNLS is a live HSV-2 ICP0- mutant vaccine strain that is profoundly attenuated in vivo due to its interferon-hypersensitivity.
William P Halford +3 more
doaj +1 more source
Disseminated HSV-2 presenting with relapsing encephalomyelitis [PDF]
Neurology Clinical Practice, 2016 A previously healthy 39-year-old woman presented with 3 weeks of progressive leg numbness. Examination showed mild bilateral iliopsoas weakness and patchy leg numbness. She was admitted, and spinal MRI revealed T2 enhancing thoracic lesions, nonenhancing cervical cord lesions (figure, A), and subtle pial and cauda equina enhancement (figure, B).
Clotilde, Hainline +6 more
openaire +2 more sources
PLoS ONE, 2010 Herpes simplex virus 1 (HSV-1) ICP0(-) mutants are interferon-sensitive, avirulent, and elicit protective immunity against HSV-1 (Virol J, 2006, 3:44).
William P Halford +2 more
doaj +1 more source
Virus-specific immune memory at peripheral sites of herpes simplex virus type 2 (HSV-2) infection in guinea pigs. [PDF]
PLoS ONE, 2014 Despite its importance in modulating HSV-2 pathogenesis, the nature of tissue-resident immune memory to HSV-2 is not completely understood. We used genital HSV-2 infection of guinea pigs to assess the type and location of HSV-specific memory cells at ...
Jingya Xia +4 more
doaj +1 more source
Risk factors for herpes simplex virus type 2 and HIV among women at high risk in northwestern Tanzania: preparing for an HSV-2 intervention trial. [PDF]
, 2007 OBJECTIVES: To determine prevalence of and risk factors for herpes simplex virus type 2 (HSV-2) and HIV among women being screened for a randomized, controlled trial of HSV suppressive therapy in northwestern Tanzania. METHODS: Two thousand seven hundred
Mugeye, Kokugonza +10 more
core +1 more source
Seroprevalence of Herpes Simplex Virus Type 1 and 2 in Taiwan and Risk Factor Analysis, 2007. [PDF]
PLoS ONE, 2015 Herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) are common human pathogens and might cause severe illness. Following primary infection, the viruses establish lifelong latent infection and are transmitted by close contact, both sexual and nonsexual ...
Jen-Hsiang Shen +5 more
doaj +1 more source