Results 61 to 70 of about 17,745,525 (306)

An HSV-2 nucleoside-modified mRNA genital herpes vaccine containing glycoproteins gC, gD, and gE protects mice against HSV-1 genital lesions and latent infection.

PLoS Pathogens, 2020
HSV-1 causes 50% of first-time genital herpes infections in resource-rich countries and affects 190 million people worldwide. A prophylactic herpes vaccine is needed to protect against genital infections by both HSV-1 and HSV-2. Previously our laboratory
Kevin P Egan, Lauren M Hook, Alexis Naughton, Norbert Pardi, Sita Awasthi, Gary H Cohen, Drew Weissman, Harvey M Friedman   +7 more
doaj   +1 more source

A live-attenuated HSV-2 ICP0 virus elicits 10 to 100 times greater protection against genital herpes than a glycoprotein D subunit vaccine. [PDF]

PLoS ONE, 2011
Glycoprotein D (gD-2) is the entry receptor of herpes simplex virus 2 (HSV-2), and is the immunogen in the pharmaceutical industry's lead HSV-2 vaccine candidate.
William P Halford, Ringo Püschel, Edward Gershburg, Andrew Wilber, Svetlana Gershburg, Brandon Rakowski   +5 more
doaj   +1 more source

Melatonin as an immunomodulator in combined therapy of herpesvirus skin diseases associated with HIV

Journal of V. N. Karazin Kharkiv National University: Series Medicine, 2021
Introduction. Highly active antiretroviral therapy is the current standard of care for patients with HIV/AIDS. Although antiretroviral therapy is etiotropic, quite effective in reducing viral load, recurrent opportunistic infections can lead to adverse ...
Diana Dorosh, Tetiana Liadova, Popov Mykola, Iryna Kadygrob, Mykola Shustval, Roman Malantschuk   +5 more
doaj   +1 more source

Incidence and risk factors for herpes simplex virus type 2 seroconversion among pregnant women in Uganda: A prospective study

Journal of Infection in Developing Countries, 2016
Introduction: Herpes simplex virus type 2 (HSV-2) acquired during pregnancy is associated with adverse outcomes such as perinatal HSV-2 transmission. HSV-2 seroconversion occurs within four weeks of HSV-2 acquisition.
Sarah Nakubulwa, Dan K Kaye, Freddie Bwanga, Nazarius Mbona Tumwesigye, Edith Nakku-Joloba, Florence M Mirembe   +5 more
doaj   +1 more source

Residual‐Lithium‐to‐LiF Conversion Enables a LiF–Fluorinated Carbon Interphase for Reconstruction‐Resistant Ni‐Rich Cathodes

Advanced Functional Materials, EarlyView.
A fluorine‐rich acrylate monomer (PFHEA) was solvent‐free applied to NCM90 and thermally decomposed under Ar to convert residual lithium into LiF and form a pre‐built LiF/fluorinated amorphous carbon (LiF/FC) interphase. The LiF/FC layer suppresses NiO rock‐salt reconstruction and microcrack propagation, lowers interfacial resistance, and improves Li ...
Pangyu Kim, Juyeon Han, Junhyeok Kim, Younghoon Kim, Eunha Seo, Dain Kim, Jeeyoung Yoo   +6 more
wiley   +1 more source

Digital Microneedles for Multiplexed Transdermal Sensing via Fluorescent QR Codes

Advanced Materials, EarlyView.
Digital fluorescent microneedles encode biochemical information in skin into scannable QR codes through threshold‐activated probes that generate binary on/off signals. By transforming analog fluorescence into discrete digital patterns, this platform enables calibration‐free, multiplexed transdermal sensing of physiologically relevant biomarkers ...
Farbod Abazar, Shahrokh Vahabi, Elena Bellotti, Martina Corsi, Irene Nocera, Paola Orlandi, Guido Bocci, Giuseppe Barillaro   +7 more
wiley   +1 more source

Anti-herpes simplex virus (HSV)-1 and anti-HSV-2 activities of monogalactosyl diacylglyceride (MGDG).

, 2019
Anti-herpes simplex virus (HSV)-1 and anti-HSV-2 activities of monogalactosyl diacylglyceride (MGDG).
Jung-Bum Lee (707906), Toshimitsu Hayashi (707908), Mana Kanazashi (6984119), Tamaki Shibayama (2263486), Kyoko Hayashi (707905), Toshio Kawahara (6790970), Kinya Atsumi (6984116), Kazumasa Okamoto (4663246)   +7 more
core   +1 more source

HSV-2 sacral radiculitis (Elsberg syndrome)

Neurology, 2004
A self-limiting syndrome of acute urinary retention in combination with variable other signs of spinal cord dysfunction and CSF pleocytosis was described by Elsberg >70 years ago.1 In many instances, a viral etiology is found, and herpes simplex virus type 2 (HSV-2) reactivation from spinal ganglia is the most common associated infection.
Eberhardt, O, Küker, W, Dichgans, J, Weller, M   +3 more
openaire   +3 more sources

Ultra‐High‐Throughput Discovery of Multifunctional Polyphenolic Coatings on Droplet Microarrays

Advanced Materials, EarlyView.
An ultra‐high‐throughput (UHT) combinatorial strategy enables the miniaturized synthesis and screening of ≈30 000 polyamine‐polyphenolic (PaPp) coatings using droplet microarrays (DMA). This approach reveals hundreds of previously unknown fluorescent, redox‐active, and antibacterial materials, including multifunctional, cell‐compatible surfaces ...
Vania Tanda Widyaya, Joaquín E. Urrutia Gómez, Paul Reuß, Alexander Welle, Rolf A. Gattung, Jana Mayer, Peter Krolla, Markus Reischl, Pascal Friederich, Anna A. Popova, Thomas Schwartz, Pavel A. Levkin   +11 more
wiley   +1 more source

Herpes Simplex Virus 1 and 2 Infections during Differentiation of Human Cortical Neurons

Viruses, 2021
Herpes simplex virus 1 (HSV-1) and 2 (HSV-2) can infect the central nervous system (CNS) with dire consequences; in children and adults, HSV-1 may cause focal encephalitis, while HSV-2 causes meningitis.
Petra Bergström, Edward Trybala, Charlotta E. Eriksson, Maria Johansson, Tugce Munise Satir, Sibylle Widéhn, Stefanie Fruhwürth, Wojciech Michno, Faisal Hayat Nazir, Jörg Hanrieder, Soren Riis Paludan, Lotta Agholme, Henrik Zetterberg, Tomas Bergström   +13 more
doaj   +1 more source