Results 81 to 90 of about 112,416,099 (307)

DeepLNM: A Multimodal Model for Predicting Lymph Node Metastasis in Colorectal Cancer

Advanced Science, EarlyView.
Traditional diagnosis may miss positive LNM cases, and pathologists face a workload; therefore, we develop DeepLNM, a multimodal model that predicts lymph node metastasis in colorectal cancer from H&E WSIs, CT images, and text. DeepLNM is robust across internal, external, and prospective cohorts and, in a user study, improves diagnostic accuracy while ...
Zhengyu Zhang, Chengyu Lu, Zhen Wang, Zhijian Cen, Yangshu Zhou, Danyi Li, Qi Xie, Bingbing Li, Shujing Guo, Zhijun Gan, Er‐ran Zhu, Jinbang Li, Aihetaimu Aimaier, Rui Mao, Weihao Qiu, Chenglong Zhao, Ying Tan, Xiaolin Liu, Huiting Ma, Tiansu Geng, Peiyue Wu, Huijun Du, Yu Wang, Yueping Liu, Li Liang   +24 more
wiley   +1 more source

Passive Color Imaging Through Macroscopic Strong Scattering Media

Advanced Science, EarlyView.
Light reflected from distant targets is severely attenuated and scattered by dense fog. A color‐channel‐simulated, independently exposed sCMOS array (CISA), combined with a passive colorful de‐scattering pipeline (PCDP), captures and reconstructs extremely weak target signals.
Renrui Wang, Xiaoyu Wang, Jianyu Wang, Zhiyu Yang, Xiangyang Ji   +4 more
wiley   +1 more source

Overcoming Out‐of‐Plane Conduction by Changing Nanosheet Morphology

Advanced Science, EarlyView.
HTaWO6 membrane made of stacked nanotubes exhibits high out‐of‐plane proton conductivity of 1.7 mS/cm. High current density (1.26 A cm−2) and power density (294 mW cm−2) indicate the potential as a fuel‐cell electrolyte. The morphology‐driven strategy establishes topology engineering as a new design principle for efficient ion transport in two ...
Yuichi Sakuda, Kazuto Hatakeyama, Asahi Yuji, Tatsuki Tsugawa, Keigo Ueno, Satsuki Tomatsu, Zulita Dian Utami, Shintaro Ida   +7 more
wiley   +1 more source

Enhanced Acoustic Adhesion Enabling Agile and Small Wall‐Climbing Robot Design With Anisotropic Origami Structure

Advanced Science, EarlyView.
This 28 g robot incorporates innovative ring structures and anisotropic origami springs to achieve high speeds and exceptional load capacity. It successfully carries a 100 g payload while ascending walls or ceilings at speeds of up to 8 and 20 cm/s, demonstrating enhanced adhesion and maneuverability over current climbing robots.
Xinxian Chen, Kanglong Yuan, Ao Qin, Yikun Liu, Yusen Ma, Jun Peng   +5 more
wiley   +1 more source

Analysis of HSV1/2 Infection Reveals an Association between HSV-2 Reactivation and Pregnancy

Viruses
The herpes simplex viruses consist of the strains, HSV-1 and HSV-2, which are prevalent worldwide and lack a definitive cure. We aimed to explore the specific characteristics of HSV 1 and 2 infections, such as differences between gender assigned at birth,
Sara Dovrat, Adar Shabat, Anat Yahav-Dovrat, Zvia Soufiev, Ella Mendelson, Ela Kashi-Zagdoun, Galia Rahav   +6 more
doaj   +1 more source

Herpes Simplex Virus Seroprevalence in Children with Autism Spectrum Disorder: A Cross-Sectional Study [PDF]

Journal of Bioscience and Applied Research
Background: exposure to these viruses, HSV-1 and HSV-2, has been linked to neurological and behavioral problems in children that exhibit symptoms similar to those of schizophrenia and autism, these Viruses can cause neuronal cell death and trigger a ...
Leqaa Radhi, Anfal Khudhair, Nawar Khalil   +2 more
doaj   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Herpes Simplex Virus Type 2 Is More Difficult to Neutralize by Antibodies Than Herpes Simplex Virus Type 1

Vaccines, 2020
Infections with herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are a global health burden. Besides painful oral or genital lesions in otherwise healthy subjects, both viruses can cause devastating morbidity and mortality in immune-compromised and
Christiane Silke Heilingloh, Christopher Lull, Elissa Kleiser, Mira Alt, Leonie Schipper, Oliver Witzke, Mirko Trilling, Anna-Maria Eis-Hübinger, Ulf Dittmer, Adalbert Krawczyk   +9 more
doaj   +1 more source

Effect of herpes simplex suppression on incidence of HIV among women in Tanzania. [PDF]

, 2008
BACKGROUND: Infection with herpes simplex virus type 2 (HSV-2) is associated with an increased risk of acquiring infection with the human immunodeficiency virus (HIV).
HSV trial team, Clare Tanton, Tim Clayton, Weiss, Helen A, Watson-Jones, Deborah, Hambleton, Ian, Louise Knight, Steering and Data Monitoring Committees, Laurent Belec, Kokugonza Mugeye, Tanton, Clare, Le Goff, Jerome, Deborah Watson-Jones, Ross, David, Knight, Louise, Baisley, Kathy, Hayes, Richard, Richard Hayes, Everett, Dean, Clayton, Tim, Kathy Baisley, Mugeye, Kokugonza, Changalucha, John, Mary Rusizoka, Helen A. Weiss, Jerome Le Goff, John Changalucha, Dean Everett, Balira, Rebecca, Ian Hambleton, Rebecca Balira, Rusizoka, Mary, David Ross, Belec, Laurent   +33 more
core   +1 more source

Phosphate‐Engineered DNA Reporters Boost CRISPR‐Cas12a Trans‐Cleavage for Rapid and Sensitive Nucleic Acid Detection

Advanced Science, EarlyView.
We uncover dual CRISPR‐Cas12a trans‐cleavage activities: endonucleolytic cleavage and 3′→5′ exonucleolytic trimming of ssDNA reporters. Mechanism‐guided 3′‐phosphate engineering accelerates substrate cleavage while favoring endonucleolytic processing, enabling Phos‐CRISPR, a rapid (20 min), highly sensitive, and specific platform for nucleic acid ...
Rui Yang, Chong Guo, Minjie Pei, Jiongyu Zhang, Xin Guan, Shuo Zhang, Xingye Liu, Kurt T. Schalper, Lori Avery, Rocco LaSala, David Banach, Changchun Liu   +11 more
wiley   +1 more source