Results 21 to 30 of about 17,745,525 (306)
Pan-HSV-2 IgG antibody in vaccinated mice and guinea pigs correlates with protection against herpes simplex virus 2. [PDF]
PLoS ONE, 2013 We lack a correlate of immunity to herpes simplex virus 2 (HSV-2) that may be used to differentiate whether a HSV-2 vaccine elicits robust or anemic protection against genital herpes.
William P Halford +2 more
doaj +1 more source
The Ticking CLOCK of HSV-2 Pathology [PDF]
Journal of Investigative Dermatology, 2018 Herpes simplex virus type 2 (HSV-2) is the causative agent of genital herpes. Matsuzawa et al have demonstrated that, in a mouse model, HSV-2 pathology is influenced by the time infection occurs. Increased expression of the HSV-2 receptor Nectin-1 under the control of CLOCK coincided with an increase in viral titer suggesting that HSV-2 infection is ...
Bayliss, Rebecca J., Piguet, Vincent
openaire +2 more sources
Viruses, 2023 Adolescents and young people are particularly vulnerable to contracting STIs, including HSV-2; furthermore, vaginal shedding of HSV-2 during pregnancy can cause vertical transmission and neonatal herpes.
Julio Cesar Muñiz-Salgado +6 more
doaj +1 more source
Vaccines, 2020 The modified vaccinia virus Ankara (MVA), a severely attenuated strain of vaccinia virus, is a promising vector platform for viral-vectored vaccine development because of its attributes of efficient transgene expression and safety profile, among others ...
Vajini N. Atukorale +2 more
doaj +1 more source
Elsberg syndrome in HSV-2 infection
IDCases, 2023 Elsberg syndrome (ES) is a neuroinflammatory disease that causes acute or subacute lumbosacral radiculitis, with or without myelitis which accounts for approximately 5-10% of cauda equina syndrome and myelitis. We herein present a case of a middle-aged female who recently returned from the Dominican Republic and presented to the emergency room with ...
Omar Belfaqeeh +4 more
openaire +3 more sources
Recurrent Benign Lymphocytic Meningitis Due to HSV-2: A Case Report
Dr. Sulaiman Al Habib Medical Journal, 2023 Recurrent benign lymphocytic meningitis (RBLM) is an uncommon form of aseptic meningitis characterized by the recurrence of meningeal symptoms followed by spontaneous recovery.
Sirine Ahmad, Mohammed Alsaeed
doaj +1 more source
Expansion of the HSV-2-specific T cell repertoire in skin after immunotherapeutic HSV-2 vaccine [PDF]
, 2022 ABSTRACT The skin at the site of HSV-2 reactivation is enriched for HSV-2-specific T cells. To evaluate whether an immunotherapeutic vaccine could elicit skin-based memory T cells, we studied skin biopsies and HSV-2-reactive CD4 + T cells from peripheral blood mononuclear cells ...
Ford, Emily S. +18 more
openaire +2 more sources
Dynamics of HSV-2 infection with a therapeutic vaccine [PDF]
Heliyon, 2020 Herpes-Simplex Virus type 2 (HSV-2) is a lifelong infection, which has infected over 400 million individuals aged 15-49 years, worldwide. While the disease can be treated with episodic and suppressive antiviral drugs to reduce the rate of recurrence (i.e., symptomatic disease) and viral shedding, none of the currently available therapies can clear the ...
Ezio Venturino +2 more
openaire +3 more sources
Human Vaccines & Immunotherapeutics, 2020 A vaccine to prevent genital herpes is an unmet public health need. We previously reported that a trivalent vaccine containing herpes simplex virus type 2 (HSV-2) glycoproteins C, D, and E (gC2, gD2, gE2) produced in baculovirus and administered with CpG/
Kevin Egan +4 more
doaj +1 more source
Drug Delivery, 2021 Chitosan glutamate (gCS) spray-dried microparticles appear promising carriers to overcome challenges associated with vaginal microbicide delivery. This study aimed at elucidating the penetration and mucoadhesive behavior of developed gCS multiunit ...
Emilia Szymańska +6 more
doaj +1 more source