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HSV shedding

Antiviral Research, 2004
Viral shedding of HSV occurs frequently in infected individuals. HSV is shed asymptomatically from multiple anatomical sites and shedding, like exposure, is a significant risk for transmission. However, the relationship between shedding frequency, viral titer and transmission is unknown. HSV-2 shedding is affected by the site and time since acquisition
S L, Sacks   +10 more
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Seroprevalence of HSV-1 and HSV-2 in Barbados

Medical Microbiology and Immunology, 2004
Type-specific enzyme-linked immunosorbent assays, based upon recombinant glycoprotein G (gG), were used to detect antibodies to HSV-1 and HSV-2, in a small Caribbean island population. A blinded serosurvey was performed on samples from 184 blood donors, 122 pregnant women, and 120 HIV-positive patients. The seroprevalence of HSV-1 and HSV-2 was 81% and
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HSV-2 transmission

Antiviral Research, 2004
A number of important risk factors for the acquisition of HSV-2 have been established including female gender, black or Hispanic ethnic origin, HIV infection, age, and increased number of sexual partners. Transmission is influenced by a number of biological factors such as sexual behavior, use of condoms, duration of relationships, and knowledge of a ...
S L, Sacks   +10 more
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HSV: immunopathological aspects of HSV infection

2007
Introduction “What is food to one man is bitter poison to others” Lucretius De Rerum Natura (50BCE) Foreign material entering multicellular organisms triggers a range of defense reactions which, when successful, subjugates and removes the invaders.
Kaustuv Banerjee, Barry T. Rouse
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Analysis of HSV Polypeptides

2003
Lytic infection by herpes simplex virus (HSV) efficiently inhibits the synthesis of most cellular proteins while a large number of viral proteins is produced, including a host shut off protein (1-3). The inhibitory effect of the protein obviously needs a certain period of time to be fully efficient, but some cellular proteins involved in virus ...
L, Haarr, N, Langeland
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Anterograde transport of HSV-1 and HSV-2 in the visual system

Brain Research Bulletin, 1992
The anterograde spread of herpesvirus in the visual system subsequent to retinitis has been observed clinically. We compared the ability of two well-studied Herpes simplex virus (HSV) strains to be transported in the anterograde direction in the hamster visual system: strain McIntyre, representing HSV-1, and strain 186, representing HSV-2. Intravitreal
R B, Norgren   +5 more
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HSV Mutagenesis

2003
Herpes genomes are large and complex, with many interactions among herpes encoded proteins, herpes DNA and RNA, and the host cell. These interactions begin as the virus enters the cell, and continue as the decision for latency or lytic replication is made.
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HSV and the CNS

The Neuroscientist, 1996
Herpes simplex virus encephalitis (HSVE) is an encephalitis with a predelection for the temporal lobes and related structures that is caused by HSV-1 or HSV-2. Because HSV has many properties that would be ideal for a gene transfer vector targeting the nervous system, an understanding of HSVE is of experimental, as well as clinical, importance to ...
Uta Meyding-Lamadé, Wolfram Lamadé
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Oncolytic Virotherapy by HSV

2018
Oncolytic virotherapy is a kind of antitumor therapy using viruses with natural or engineered tumor-selective replication to intentionally infect and kill tumor cells. An early clinical trial has been performed in the 1950s using wild-type and non-engineered in vitro-passaged virus strains and vaccine strains (first generation oncolytic viruses ...
Daisuke, Watanabe, Fumi, Goshima
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HSV Entry and Spread

2003
This chapter deals with assays commonly used to follow herpes simplex virus type 1 (HSV-1) entry into and spread between cells in tissue culture These are complex processes, known to involve several of the 20 or more HSV-encoded membrane proteins (see refs. 1 and 2 for recent reviews). HSV entry is mediated by a number of proteins on the surface of the
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