Results 81 to 90 of about 34,765 (207)

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

Modeling HTLV-1 and HTLV-2 co-infection dynamics

AIMS Mathematics
With the increasing prevalence of viral infections, the human T-cell leukemia virus (HTLV) is becoming a focal point of research. Of the four identified strains, HTLV-1 and HTLV-2 are particularly associated with various health issues. Both strains exhibit similar biological characteristics and transmission pathways, making them prevalent in specific ...
E. A. Almohaimeed, A. M. Elaiw, A. D. Hobiny   +2 more
openaire   +2 more sources

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Regulation of AP-1 activity by the HTLV-2 APH-2 protein [PDF]

Retrovirology, 2011
In contrast to HTLV-1 which causes adult T-cell leukemia/lymphoma (ATL/ATLL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), the role of HTLV-2 in human disease is less clearly defined but infection is associated with rare lympho-proliferative and neurological disorders.
Sheehy Noreen, Hall William W, Marban Céline   +2 more
openaire   +2 more sources

HTLV-1/-2 and HIV-1 Co-infections: Retroviral Interference On Host Immune Status

Frontiers in Microbiology, 2013
The human retroviruses HIV-1 and HTLV-1/HTLV-2 share similar routes of transmission but cause significantly different diseases. In this review we have outlined the immune mediated mechanisms by which HTLVs affect HIV-1 disease in co-infected hosts ...
Elisabetta ePilotti, Vittoria eBianchi, Andrea eDe Maria, Andrea eDe Maria, Andrea eDe Maria, Federica eBozzano, Federica eBozzano, Maria Grazia Romanelli, Umberto eBertazzoni, Claudio eCasoli   +9 more
doaj   +1 more source

Transcriptomic analyses reveal that the cellular Gem protein promotes HTLV-1 infected cell migration and viral transmission [PDF]

, 2014
International ...
Chevalier, Sébastien, Gessain, Antoine, Mahieux, Renaud, Pise-Masison, Cynthia   +3 more
core   +4 more sources

Pathogen‐reduced platelet concentrates in France: Impact on the risk of transfusion‐transmitted infections, 2017–2024

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Pathogen reduction (PR) using amotosalen‐UVA was implemented for 100% of platelet concentrates (PCs) in France in November 2017. No bacterial testing was in place earlier. The impact of PR on the risk of transfusion‐transmitted infections (TTIs) from November 2017 to December 2022 (vs.
Syria Laperche, Virginie de la Taille, Pierre Gallian, Elodie Pouchol, Catherine Humbrecht, Alexandre Montembault, Lucile Malard, Caroline Bacquet, Marianne Asso‐Bonnet, Sophie Le Cam, Thierry Peyrard, Pierre Tiberghien   +11 more
wiley   +1 more source

Re‐entry of donors deferred for false‐reactive screening tests in Canada: 10 years post implementation

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Canadian Blood Services implemented a re‐entry programme in 2014. Donors deferred because of false‐reactive or indeterminate screening tests can provide a specimen for re‐entry testing 6 months after their initial test, and resume donating if they test negative for all infectious markers.
Chinchin Wang, Steven J. Drews, Mark Bigham, Mindy Goldman, Sheila F. O'Brien   +4 more
wiley   +1 more source

Peripheral T‐Cell Lymphomas in Southern Taiwan: Epidemiology, Treatment Patterns, and Long‐Term Outcomes

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Peripheral T‐cell lymphomas (PTCLs) are heterogeneous neoplasms with poor prognosis and marked geographic variation. Data from Taiwan remain limited. We conducted a 15‐year retrospective cohort study of 249 patients diagnosed with PTCL at two major centers in southern Taiwan between 2010 and 2024 to characterize regional epidemiology, real ...
Bo‐Yu Huang, Li‐Chang Chang, Sheng‐Yen Hsiao, Ya‐Ping Chen, Sin‐Syue Li, Pei‐An Fu, Chen Chang, Kung‐Chao Chang, Tsai‐Yun Chen, Ya‐Ting Hsu   +9 more
wiley   +1 more source

Comparative host protein interactions with HTLV-1 p30 and HTLV-2 p28: insights into difference in pathobiology of human retroviruses

Retrovirology, 2012
Background Human T lymphotropic virus type-1 (HTLV-1) and type 2 (HTLV-2) are closely related human retroviruses, but have unique disease associations.
Doueiri Rami, Anupam Rajaneesh, Kvaratskhelia Mamuka, Green Kari B, Lairmore Michael D, Green Patrick L   +5 more
doaj   +1 more source