Results 31 to 40 of about 29,485 (183)

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

The Impact of Immune Response on HTLV-I in HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) [PDF]

Iranian Journal of Basic Medical Sciences, 2013
Human T lymphotropic virus type I (HTLV-I) is a retrovirus which is associated with adult T cells leukaemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a minority of HTLV-I-infected individuals.
Houshang Rafatpanah, Reza Farid Hosseini2, Seyed Hassan Pourseyed   +2 more
doaj  

Erectile insufficiency as first symptom of HTLV-I/II associated myelopathy: case report Insuficiência erétil como primeiro sintoma da mielopatia associada ao HTLV I/II: relato de caso

Arquivos de Neuro-Psiquiatria, 1998
A case of HTLV-I/II myelopathy in which the initial complaint was erectile insufficiency (EI) is reported. The only abnormalities found on the neurological exam were discrete weakness of the psoas and increased knee jerk reflexes.
JOSÉ TEOTONIO OLIVEIRA, ANNA BÁRBARA F. CARNEIRO-PROIETTI, MARIA VIRGÍNIA C. LIMA-MARTINS, MARINA LOBATO MARTINS, FERNANDO AUGUSTO PROIETTI   +4 more
doaj   +1 more source

Glycoengineered Recombinant Alpha1‐Antitrypsin Results in Comparable In Vitro and In Vivo Activities to Human Plasma‐Derived Protein

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Alpha‐1‐antitrypsin (A1AT) is a multifunctional, clinically important, high‐value therapeutic glycoprotein that can be used for the treatment of many diseases, such as A1AT deficiency, diabetes, graft‐versus‐host disease, cystic fibrosis, and various viral infections. Currently, the only U.S. food and drug administration‐approved treatment for
Frances Rocamora, Chen‐Lin Hsieh, Sanne Schoffelen, Johnny Arnsdorf, Eric A. Toth, Abdul S. Yunus, Thomas E. Cleveland IV, Sara Petersen Bjørn, Mina Ying Min Wu, Noel G. McElvaney, Bjørn Gunnar Rude Voldborg, Thomas R. Fuerst, Nathan E. Lewis   +12 more
wiley   +1 more source

Heat Shock Enhances the Expression of the Human T Cell Leukemia Virus Type-I (HTLV-I) Trans-Activator (Tax) Antigen in Human HTLV-I Infected Primary and Cultured T Cells

Viruses, 2016
The environmental factors that lead to the reactivation of human T cell leukemia virus type-1 (HTLV-I) in latently infected T cells in vivo remain unknown.
Marie Kunihiro, Hideki Fujii, Takuya Miyagi, Yoshiaki Takahashi, Reiko Tanaka, Takuya Fukushima, Aftab A. Ansari, Yuetsu Tanaka   +7 more
doaj   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Pulmonary function testing in HTLV-I and HTLV-II infected humans: a cohort study

BMC Pulmonary Medicine, 2003
Background HTLV-I infection has been linked to lung pathology and HTLV-II has been associated with an increased incidence of pneumonia and acute bronchitis. However it is unknown whether HTLV-I or -II infection alters pulmonary function.
Garratty George, Smith James W, Ownby Helen E, Murphy Edward L, Hutching Sheila T, Wu Ying, Ameti Dannie I   +6 more
doaj   +1 more source

Burden and Correlates of Multiple Chronic Infections and Their Associations With Cancer Incidence in Chinese Adults: A Large Case‐Cohort Study

International Journal of Cancer, EarlyView.
While several oncogenic pathogens cause site‐specific cancers, uncertainties remain about many other chronic infections and combined pathogen effects, especially in non‐Western populations. Using a large case–cohort study nested within the China Kadoorie Biobank, the authors found that co‐infection was common, with a mean of 10 pathogens per individual.
Ling Yang, Jonathan Clarke, Lea Kröller, Christiana Kartsonaki, Hannah Fry, Rima Jeske, Andrew Gordon, Sarah Clark, Michael Hill, Daniel Avery, Yiping Chen, Huaidong Du, Jun Lv, Dianjianyi Sun, Canqing Yu, Liming Li, Iona Y. Millwood, Tim Waterboer, Zhengming Chen, on behalf of the China Kadoorie Biobank Collaborative Group, Junshi Chen, Zhengming Chen, Robert Clarke, Rory Collins, Liming Li, Jun Lv, Richard Peto, Robin Walters, Liming Li, Jun Lv, Canqing Yu, Dianjianyi Sun, Yuanjie Pang, Yuting Han, Can Hou, Qingmei Xia, Chao Liu, Pei Pei, Lang Pan, Xiao Han, Honglu Bian, Xinxin Chen, Daniel Avery, Maxim Barnard, Derrick Bennett, Ruth Boxall, Yiping Chen, Zhengming Chen, Jonathan Clarke, Robert Clarke, Huaidong Du, Ahmed Edris Mohamed, Hannah Fry, Prapthi Harish, Pek Kei Im, Andri Iona, Christiana Kartsonaki, Kshitij Kolhe, Hubert Lam, Kuang Lin, James Liu, Iona Millwood, Sam Morris, Qunhua Nie, Alfred Pozarickij, Maryam Rahmati, Paul Ryder, Maruf Sarder, Dan Schmidt, Becky Stevens, Iain Turnbull, Robin Walters, Baihan Wang, Lin Wang, Neil Wright, Ling Yang, Xiaoming Yang, Pang Yao, Zengchang Pang, Ruqin Gao, Kunzheng Lv, Shanpeng Li, Haiping Duan, Shaojie Wang, Yongmei Liu, Ranran Du, Liang Cheng, Xiaocao Tian, Hua Zhang, Dan Hu, Xiaoyan Zheng, Yujie Wang, Wei Sun, Shichun Yan, Chi Wang, Zhenyuan Wu, Lishun Zhai, Zhaoxi Pang, Shiwen Dong, Li Liu, Dapeng Yin, Bin He, Ying Liu, Xingren Wang, Tingting Ou, Xiangyang Zheng, Dewei Zheng, Shuai Yang, Lihui Li, Xingjiao Chen, Yan Xu, Jinyi Zhou, Ran Tao, Jian Su, Xikang Fan, Xuejia Chen, Yuxiao Huang, Yan Lu, Yujie Hua, Li Xing, Shuxian Wang, Jianrong Jin, Juping Ma, Jinchao Liu, Kaifei Zhu, Hongfu Ren, Xingfeng Shen, Ge Zhong, Wei Mao, Zhenzhen Lu, Yanxu Zhong, Lifang Zhou, Rong Pan, Jian Lan, Xiaoping Tan, Jinxue Tan, Yishan Xie, Liuping Wei, Liyuan Zhou, Sisi Wang, Xianping Wu, Ningmei Zhang, Xiaofang Chen, Xiaoyu Chang, Zhuo Wang, Yujin He, Mingqiang Yuan, Ling Wang, Xiaofang Chen, Zhaodong Wang, Qiang Sun, Yang Lin, Faqing Chen, Xiaolan Ren, Lijun Chang, Feiming Zhong, Jianjun Feng, Weijie Hu, Xiaofang Zhang, Yalin Chen, Honghong Wang, Jun Wang, Linqi Diao, Zhiwei Han, Dengjun Zhu, Kai Kang, Shixian Feng, Wenjie Yang, Huizi Tian, Yali Yan, Bing Han, Li Gao, Shaofang Li, Tianfang Xing, Wei Tang, Xiaolin Li, Huarong Sun, Xiaocong Zhao, Ying Li, Chen Hu, Pan He, Xukui Zhang, Yuanyuan Jin, Lan Luo, Min Yu, Ruying Hu, Hao Wang, Weiwei Gong, Jieming Zhong, Meng Wang, Chunxiao Xu, Keqing Gong, Hao Xu, Yuan Cao, Kaixu Xie, Lingli Chen, Xiaomei Tu, Junlong Pan, Xiaojun Li, Li Yin, Huilin Liu, Yuan Liu, Lei Yin, Xian Xie, Jing Wang, Bo Xiao, Zongwei Deng, Yuan Peng, Libo Zhang, Chan Qu, li Deng, Qili Jiang, Yanling Chen   +212 more
wiley   +1 more source

The Relevance of HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis in Iran: A Review Study [PDF]

Reviews in Clinical Medicine, 2019
Human T-cell lymphotropic virus type I (HTLV-I) is a retrovirus, which is the causative agent of adult T-cell leukaemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
Masoud Keikha, mohsen Karbalaei Zadeh Babaki, Luiz Augusto Marcondes Fonseca, Jorge Casseb   +3 more
doaj   +1 more source