Results 31 to 40 of about 13,356,633 (261)

A Relational Learning Approach to Structure-Activity Relationships in Drug Design Toxicity Studies

Journal of Integrative Bioinformatics, 2011
It has been recognized that the development of new therapeutic drugs is a complex and expensive process. A large number of factors affect the activity in vivo of putative candidate molecules and the propensity for causing adverse and toxic effects is ...
Camacho Rui, Pereira Max, Costa Vítor Santos, Fonseca Nuno A., Adriano Carlos, Simões Carlos J. V., Brito Rui M. M.   +6 more
doaj   +1 more source

Desarrollo del nuevo paradigma educativo. Más allá de la formación online: la formación en red

RIED: Revista Iberoamericana de Educación a Distancia, 2002
En este artículo tratamos de analizar en primer lugar las ventajas que ha supuesto la integración de las Nuevas Tecnologías, sobre todo Internet y el correo electrónico, en la educación a distancia. Es lo que a se ha llamado e-learning o formación online.
Luis Ángel Fernández Hermana, Iban García Casals, Rafa Martín   +2 more
doaj   +1 more source

Limitless HTTP in an HTTPS World

Proceedings of the Ninth ACM Conference on Data and Application Security and Privacy, 2019
We present new analytic techniques for inferring HTTP semantics from passive observations of HTTPS that can infer the value of important fields including the status-code, Content-Type, and Server, and the presence or absence of several additional HTTP header fields, e.g., Cookie and Referer.
Anderson, Blake, Chi, Andrew, Dunlop, Scott, McGrew, David   +3 more
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

ВЫБОР ВЕБ-ТЕХНОЛОГИИ ДЛЯ ИНТЕГРАЦИИ С ПЛАТФОРМОЙ «1С: ПРЕДПРИЯТИЯ 8»

Cifra: Информационные технологии и телекоммуникации
В статье разобраны способы интеграции платформы «1С: Предприятие 8» с веб-технологиями для создания альтернативного пользовательского интерфейса, разрешающего задачи, возникающие у предприятия: реализация интерфейса для работы сотрудников и разработка ...
Ширяев А.И.
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source