Results 41 to 50 of about 32,566,170 (304)
Web Performance Characteristics of HTTP/2 and Comparison to HTTP/1.1 [PDF]
, 2018 The HTTP/1.1 protocol has long been a staple on the web, for both pages and apps. However, it has started to show its age, especially with regard to page load performance and the overhead it entails due to its use of multiple underlying connections. Its successor, the newly standardized HTTP/2, aims to improve the protocol’s performance and reduce its ...
Robin Marx +4 more
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Супян Виктор Борисович http://americana.socionet.ru/files/Supyan.jpg [PDF]
: Супян Виктор Борисович, доктор экономических наук, профессор, заместитель директора Института США и Канады РАН (экономическое и управленческое направление, Диссертационный совет (экономический)). Родился 12 января 1948 г. в г. Москва.
http://www.iskran.ru/usovet.php?id=33Contacts: VSupyan@yahoo.com
core +2 more sources
Радіоелектронні і комп'ютерні системиThe subject matter of this article is the methods to detect distributed denial-of-service (DDoS) attacks at the Hypertext Transfer Protocol (HTTP) level with the purpose of justifying the requirements for creating software capable of identifying ...
Arkadii Kravchuk, Mykola Onai
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
, 1895 D majorAll brillanteA Seville, belles Senoras, On brave les frimas8205Published by Heugel & Cie Au Ménestrel, 2bis.
Massenet, Jules, 1842-1912 +3 more
core
A Relational Learning Approach to Structure-Activity Relationships in Drug Design Toxicity Studies
Journal of Integrative Bioinformatics, 2011 It has been recognized that the development of new therapeutic drugs is a complex and expensive process. A large number of factors affect the activity in vivo of putative candidate molecules and the propensity for causing adverse and toxic effects is ...
Camacho Rui +6 more
doaj +1 more source
Desarrollo del nuevo paradigma educativo. Más allá de la formación online: la formación en red
RIED: Revista Iberoamericana de Educación a Distancia, 2002 En este artículo tratamos de analizar en primer lugar las ventajas que ha supuesto la integración de las Nuevas Tecnologías, sobre todo Internet y el correo electrónico, en la educación a distancia. Es lo que a se ha llamado e-learning o formación online.
Luis Ángel Fernández Hermana +2 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source