Results 51 to 60 of about 13,356,633 (261)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
GeoServer: il server geospaziale Open Source novità della nuova versione 2.3.0
GEOmedia, 2013 GeoServer è un server geospaziale Open Source sviluppato con tecnologia Java Enterprise per la gestione e l’editing di dati geospaziali secondo gli standard OGC e ISO Technical Committee 211.
Simone Giannecchini, Andrea Aime
doaj +2 more sources
El Gloria Fuertes, otra escuela posible
Revista Interuniversitaria de Formación del Profesorado, 2008 En el presente artículo se glosa la trayectoria pedagógica del Colegio Público de Educación Especial Gloria Fuertes de Andorra (Teruel), un centro que constituye una referencia obligada, a nivel nacional e internacional, en los ámbitos científico ...
José Emilio PALOMERO PESCADOR
doaj
ADOPS - Automatic Detection Of Positively Selected Sites
Journal of Integrative Bioinformatics, 2012 Maximum-likelihood methods based on models of codon substitution have been widely used to infer positively selected amino acid sites that are responsible for adaptive changes.
Reboiro-Jato David +5 more
doaj +1 more source
The effect of expanded polystyrene on the heating of particle-polymer package
Наукові праці Лісівничої академії наук України, 2019 This paper is devoted to the study of the influence of expanded polystyrene on the heating of the particle-polymer package during the hot pressing of lightweight particleboards.
Pavlo Bekhta , Liubov Baizova
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Le novità in Quantum GIS: versione 1.8 “Lisboa” ed oltre
GEOmedia, 2013 Quantum GIS, il noto programma GIS libero ed Open Source distribuito con licenza GPL, hacompiuto nel 2012 i primi 10 anni di vita. La sua popolarità tra gli utenti finali è in continuoaumento* (statistiche dei download, gistackexchange, google trends ...
Giovanni Manghi, Paolo Cavallini
doaj +2 more sources
Conocimientos y prácticas de alimentación en gestantes atendidas en un hospital de lima, 2017
Revista de la Facultad de Medicina Humana, 2018 Objetivos: Determinar la asociación entre los conocimientos y las prácticas de alimentación en gestantes atendidas en un Hospital de Lima el mes de setiembre 2017. Métodos: Se realizó un estudio analítico, observacional, cuantitativo y transversal.
Cinthia Francia-Ramos +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source