Results 201 to 210 of about 243,473 (347)

Connecting myelin-related and synaptic dysfunction in schizophrenia with SNP-rich gene expression hubs [PDF]

, 2017
Hédi Hegyi
openalex   +1 more source

Identification Cure Hub Genes of Chromophobe Cell Renal Carcinoma : A study based on Weighted Gene Co-expression Network Analysis (WGCNA) and the Cure Defective Models [PDF]

, 2023
Maryam Ahmadian, Zahra Molavi, Ahmad Reza Baghestani, Ali Akbar Khadem Maboudi   +3 more
openalex   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Dysregulated NF-κB signal promotes the hub gene PCLAF expression to facilitate nasopharyngeal carcinoma proliferation and metastasis

, 2020
Feifei Ma, Cheng Zhi, Minling Wang, Tao Li, Shahzad Akbar Khan, Zhaoen Ma, Zhi-Liang Jing, Bo Chen, Qiang Zhou, Shaomei Xia, Shiwen Huang, Sicong Huang, Zhiquan Zhang, Hongyun Jia, Xiaogang Cui, Mingze Yao, Tianxing Ji   +16 more
openalex   +1 more source

Stress‐Programmed Immune Niches Fuel TNFR2+ Treg Activation and Drive Neoadjuvant Chemotherapy Resistance in Breast Cancer

Advanced Science, EarlyView.
Single‐cell sequencing reveals stress‐programmed immune states driving TNFα–TNFR2–mediated Treg activation and therapy resistance in breast cancer, while targeting this axis restores antitumor immunity. ABSTRACT The tumor microenvironment (TME) harbors diverse immune cell states that shape therapeutic outcomes in breast cancer.
Zhibo Shao, Xuliren Wang, Han Zhu, Ling Yao, Qi Zhang, Zihan Zhai, Xinyi Lv, Xinyuan Xia, Yi Zhang, Xinya Lu, Xinyi Quan, Jiawen Yang, Xinwei Li, Jieyi Dong, Zhi‐ming Shao, Ruoxi Wang, Bingqiu Xiu, Jiong Wu, Sheng Chen   +18 more
wiley   +1 more source

Identification of 10 Hub genes related to the progression of colorectal cancer by co-expression analysis

, 2020
Jie Meng, Rui Su, Yun Liao, Yanyan Li, Ling Li   +4 more
openalex   +1 more source

Identification of regulatory networks and hub genes controlling soybean seed set and size using RNA sequencing analysis [PDF]

, 2017
Juan Du, Shoudong Wang, Cunman He, Bin Zhou, Yong‐Ling Ruan, Huixia Shou   +5 more
openalex   +1 more source

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

Advanced Science, EarlyView.
Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
wiley   +1 more source

Integrated Analyses Identify CDH2 as a Hub Gene Associated with Cisplatin Resistance and Prognosis in Ovarian Cancer. [PDF]

Int J Mol Sci
Xu JY, Tian MQ, Yang R, Li ZX, Lin ZH, Wang YF, Chu YH, Sun WN, Wang YM.   +8 more
europepmc   +1 more source

Identifying Hub Genes and Metabolic Pathways in Collagen VI-Related Dystrophies: A Roadmap to Therapeutic Intervention [PDF]

Atakan Burak Ceyhan, Ali Kaynar, Özlem Altay, Cheng Zhang, Şehime Gülsün Temel, Hasan Türkez, Adil Mardinoğlu   +6 more
openalex   +1 more source