Results 191 to 200 of about 10,923,960 (347)

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

united-manufacturing-hub/united-manufacturing-hub: v0.10.4

<h2><a href="https://github.com/united-manufacturing-hub/united-manufacturing-hub/compare/v0.10.3...v0.10.4">0.10.4</a> (2024-01-25)</h2> <h3>Bug Fixes</h3> <ul> <li>no trailing / for registry (<a href ...
kruegeralex, Matteo Danelon, Oto.Nak, fossabot, David Mackel, Ferdinand Linnenberg, JonaVo, Ricardo Christmann, Robert Feldmann, actions-user, Lukas Hennies, ONUR CAN KARAMAN, larswitte, Matthew Judijanto, Semantic Release Bot, Pascal Bro, AMINE AMAACH, Derek Tiffany, Arne, Patrick Melichar, chrisproch, felixmhofmann, Jeremy Theocharis   +22 more
core   +1 more source

Identification of potential biomarkers and therapeutic targets for underactive bladder based on bioinformatics analysis and experimental validation.

PLoS ONE
Underactive bladder (UAB) is a common disorder that significantly affects patients' quality of life, necessitating the exploration of underlying molecular mechanisms for more effective management. This study aims to elucidate the gene expression profiles
Chen Chen, Zhuojing Hu, Yunbo Ma, Qinghua Xia, Zheng Ma, Jiangsong Li, Wei Zhao   +6 more
doaj   +1 more source

Exploring the common mechanism of vascular dementia and inflammatory bowel disease: a bioinformatics-based study

Frontiers in Immunology
ObjectiveEmerging evidence has shown that gut diseases can regulate the development and function of the immune, metabolic, and nervous systems through dynamic bidirectional communication on the brain-gut axis.
Yujiao Wang, Daojun Xie, Shijia Ma, Nan Shao, Xiaoyan Zhang, Xie Wang   +5 more
doaj   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

united-manufacturing-hub/united-manufacturing-hub: v0.13.6

<h2><a href="https://github.com/united-manufacturing-hub/united-manufacturing-hub/compare/v0.13.5...v0.13.6">0.13.6</a> (2024-03-13)</h2> <h3>Bug Fixes</h3> <ul> <li>force new release (<a href="https ...
kruegeralex, Matteo Danelon, Oto.Nak, fossabot, David Mackel, Ferdinand Linnenberg, JonaVo, Ricardo Christmann, Robert Feldmann, actions-user, Lukas Hennies, ONUR CAN KARAMAN, larswitte, Matthew Judijanto, Semantic Release Bot, Pascal Bro, AMINE AMAACH, Derek Tiffany, Arne, Patrick Melichar, chrisproch, felixmhofmann, Jeremy Theocharis   +22 more
core   +1 more source

The identification of key genes and pathways in polycystic ovary syndrome by bioinformatics analysis of next-generation sequencing data

Middle East Fertility Society Journal
Background Polycystic ovary syndrome (PCOS) is a reproductive endocrine disorder. The specific molecular mechanism of PCOS remains unclear. The aim of this study was to apply a bioinformatics approach to reveal related pathways or genes involved in the ...
Varun Alur, Basavaraj Vastrad, Varshita Raju, Chanabasayya Vastrad, Shivakumar Kotturshetti   +4 more
doaj   +1 more source

Experimental validation of cuproptosis-associated molecular signatures and their immunological implications in pulmonary tuberculosis

Frontiers in Immunology
BackgroundThe pathogenic mechanism underlying Mycobacterium tuberculosis (MTB) remains elusive, posing challenges to its diagnosis and treatment. Cuproptosis is a newly identified mechanism of cell death.
Xiaofang Liu, Xiaofang Liu, Qianqian Ma, Zhiming Li, Yong Xue, Jie Mi, Yuxi Li, Chunfeng Bai, Donglin Guo, Yinping Liu, Yan Liang, Jianqin Liang, Xueqiong Wu   +12 more
doaj   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source