Results 181 to 190 of about 100,698 (279)

Mechanisms of cellular senescence combined with molecular docking strategies: A biomarker study of potential therapeutic targets for allergic rhinitis.

PLoS ONE
ObjectiveBioinformatics and molecular docking methods were used to screen potential biomarkers of cellular senescence in allergic rhinitis (Allergic rhinitis AR), which provided a theoretical basis for revealing the mechanism of AR and exploring new ...
Qingyong Chen, Han Zhang, Yue Wu, Jixin Liu, Dongqing Wang, Dezhong Sun, Zhipeng Chen, Liqiang Lin, Huaiqing Lv, Qiang Shao   +9 more
doaj   +1 more source

Identification of hub genes associated with postmenopausal osteoporosis by Gibbs sampling method

, 2019
Yapeng Zhang, Shuang Ao, Yu Liu, Yu Wang, Yiming Jia, Hao Zhang, Hui Leng   +6 more
openalex   +2 more sources

Nuclear speckles: dynamic hubs of gene expression regulation

, 2022
Complex, multistep biochemical reactions that routinely take place in our cells require high concentrations of enzymes, substrates, and other structural components to proceed efficiently and typically require chemical environments that can inhibit other reactions in their immediate vicinity.
Ilik, I., Aktas, T.
openaire   +1 more source

Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity

Advanced Science, EarlyView.
Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang, Siqi Ren, Yuhui Li, Rongxi Chen, Ling Qiu, Yongmei Tan, Suling Chen, Huiqian Wu, Lianxi Mai, Xiao Tan, Xin Liu, Peisheng Liang, Shijia Kuang, Liansheng Wang, Jingkang Liu, Jintao Li, Yanyan Li, Qiuping Xu, Yongzhi Su, Yuehai Luo, Binyan Wu, Zijing Huang, Haotian Cao, Qunxing Li, Jinsong Li, Tianjun Lan   +25 more
wiley   +1 more source

Additional file 10 of Transcriptomic analysis reveals hub genes and subnetworks related to ROS metabolism in Hylocereus undatus through novel superoxide scavenger trypsin treatment during storage

, 2020
Xin Li, Xueru Liu, Xinyue Pang, Yong Yin, Huichun Yu, Yunxia Yuan, Bairu Li   +6 more
openalex   +1 more source

Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation

Advanced Science, EarlyView.
Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Zhiguo Li, Huiyi Quan, Wanting Liu, Jiaoling Chen, Mengyang Chu, Xin Tang, Ke Xue, Xuan Liu, Jingyi Ma, Yaxing Bai, Ruina Dong, Bing Li, Junfeng Hao, Wei Guo, Qingyang Li, Erle Dang, Johann E Gudjonsson, Gang Wang, Shuai Shao   +18 more
wiley   +1 more source

Additional file 15 of Transcriptomic analysis reveals hub genes and subnetworks related to ROS metabolism in Hylocereus undatus through novel superoxide scavenger trypsin treatment during storage

, 2020
Xin Li, Xueru Liu, Xinyue Pang, Yong Yin, Huichun Yu, Yunxia Yuan, Bairu Li   +6 more
openalex   +1 more source

A Cold Stress‐Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor

Advanced Science, EarlyView.
Seasonal cold adaptation is vital for insect survival, yet the molecular mechanisms linking diapause to mitochondrial resilience remain largely unresolved. We identify ascaroside C9 (asc‐C9) as a key endocrine signal that enhances diapause survival during cold stress by activating the AKHR–PGC1α–UCP4 axis, thereby driving cold‐induced lipolysis and ...
Jiao Zhou, Junxian Chen, Hongxia Zhang, Lu Guo, Kevin Mai, Elijah Abraham, Dilip V. Prajapati, Yue Chang, Jing Ning, Xinchen Wang, Defeng Li, Dan‐Dan Zhang, Jianghua Sun, Rebecca A. Butcher, Lilin Zhao   +14 more
wiley   +1 more source

Peer Review #1 of "Identification of hub genes and transcription factor-miRNA-mRNA pathways in mice and human renal ischemia-reperfusion injury (v0.1)"

, 2021
Ke Peng, Qian Lin, Yi Zhou, Feng Liu, Zhentao Zhang, Chengjie Zheng, Mengnan Chen, Xinlei Huang, Xiaodan Wu, Feng Liu, T Ali, I Khan, W Simpson, G Prescott, J Townend, W Smith, A Macleod, Ambros, D Aufhauser, P Hernandez, S Concors, O 'brien, C Wang, Z Murken, D Samanta, A Beier, U Krumeich, L Bhatti, T Wang, Y Ge, G Wang, L Cheraghlou, S Wagner, F Holson, E Kalin, J Cole, P Hancock, W Levine, M, G Bader, Cwv Hogue, M Bai, H Chen, D Ding, R Song, J Lin, Y Zhang, Y Guo, S Chen, G Ding, Y Zhang, Z Jia, S Huang, J He, L Yang, A Zhang, T Barrett, S Wilhite, P Ledoux, C Evangelista, I Kim, M Tomashevsky, K Marshall, K Phillippy, P Sherman, M Holko, A Yefanov, H Lee, N Zhang, C Robertson, N Serova, S Davis, A Soboleva, H Chen, Y Lan, H Li, C Cheng, P Lai, W Li, H Lin, Y Chen, X Wang, D Chernyakov, A Gro, A Fischer, N Bornkessel, C Schultheiss, D Gerloff, B Edemir, M Correa-Costa, H Azevedo, M Amano, G Gonalves, M Hyane, M Cenedeze, P Renesto, A Pacheco-Silva, C Moreira-Filho, Nos Cmara, W Deng   +99 more
openalex   +2 more sources

Identification of Key Modules, Hub Genes, and Noncoding RNAs in Chronic Rhinosinusitis with Nasal Polyps by Weighted Gene Coexpression Network Analysis [PDF]

, 2020
Xuanchen Zhou, Xiaoyue Zhen, Yiqing Liu, Zhaoyang Cui, Zhiyong Yue, Anting Xu, Jie Han   +6 more
openalex   +1 more source