Results 301 to 310 of about 194,990 (329)

DECIPHERING KEY HUB GENES IN MEDULLOBLASTOMA: INTEGRATIVE ANALYSIS OF TRANSCRIPTOMIC DATASETS REVEALS POTENTIAL BIOMARKERS AND THERAPEUTIC TARGETS

Muhammad Afzal
openalex   +1 more source

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

NHP2 and PRPF4 are hub genes associated with the prognosis of colorectal cancer. [PDF]

BMC Cancer
Li N, Gao LJ, Guo KX, Wang J, Wang DP, Hou JY, Cao JM.   +6 more
europepmc   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Multi-omics reveals efferocytosis-related hub genes as biomarkers for ustekinumab response in colitis. [PDF]

Front Immunol
Wang JM, Xia WY, Liao YS, Yuan J.
europepmc   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Integrative single-cell transcriptomic analysis reveals immunomodulatory hub genes and candidate compounds for HIV-associated chronic inflammation. [PDF]

Virol J
Hasan MI, Mummidi S, Teufel AI.
europepmc   +1 more source

Identification and analysis of the endoplasmic reticulum stress hub genes in sepsis-associated ARDS. [PDF]

Sci Rep
Gao L, Liu T, Li X.
europepmc   +1 more source

Comprehensive Bioinformatic Analysis Reveals Survival-Associated Hub Genes and MicroRNAs in Multiple Myeloma Patients. [PDF]

Iran J Biotechnol
Hatef E, Bayat R, Seyed Hosseini E, Rahmatipour S, Rezvani Z, Haddad Kashani H.   +5 more
europepmc   +1 more source

Stimulator of interferon genes signaling network‑driven prognostic signature for pancreatic cancer: Hub gene discovery with multimodal validation

Wenjing Yu, Junqun Liao, Jiayan Li, Yongquan Wu   +3 more
openalex   +1 more source