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Spatial organization of gene expression: the active chromatin hub
Chromosome Research, 2003Developmental and tissue-specific expression of higher eukaryotic genes involves activation of transcription at the appropriate time and place and keeping it silent otherwise. Unlike housekeeping genes, tissue-specific genes generally do not cluster on the chromosomes.
de Laat, WL (Wouter), Grosveld, Frank
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Identification of Potential Hub Genes in Alopecia Areata
Experimental DermatologyABSTRACT Alopecia areata (AA) is an immune‐mediated chronic alopecia disease, but its specific pathogenesis is unclear. Gene expression data for AA patients (AAs) and healthy controls (HCs) were retrieved from the GEO database, and the differentially expressed genes (DEGs) between AAs and HCs were identified.
Runqiu Liu +7 more
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Identification of hub genes and pathways in cholangiocarcinoma by coexpression analysis
Cancer Biomarkers, 2020BACKGROUND: Cholangiocarcinoma (CCA) is the most common biliary malignancy worldwide. However, the molecular mechanisms of its tumorigenesis and progression are still largely unclear. OBJECTIVE: This study aimed to explore the hub genes and pathways associated with CCA prognosis by coexpression analysis.
Junjie, Kong +3 more
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Identifying Hub Genes Associated with Sex Disparities in Prolactinomas
Genetic Testing and Molecular BiomarkersBackground: Male patients with prolactinomas exhibit greater invasiveness, resistance to dopamine agonists, making treatment more challenging. This study aims to explore the potential different genes contributing to sex disparities in prolactinomas ...
Yuan Zhang +5 more
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Unveiling the Hub Genes Involved in Cadmium-Induced Hepatotoxicity
Biological Trace Element ResearchCadmium (Cd) is a highly toxic heavy metal that can cause severe liver damage in both humans and animals. However, the specific genes responsible for Cd-induced hepatotoxicity are still not fully understood. Therefore, the aim of this study was to identify the key genes associated with Cd-induced liver damage.
Bing, Yang +3 more
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