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Association analysis of hepatocellular carcinoma‐related hub proteins and hub genes
PROTEOMICS – Clinical Applications, 2023AbstractPurposeHepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The occurrence and development of HCC are closely related to epigenetic modifications. Epigenetic modifications can regulate gene expression and related functions through DNA methylation.
Xinhong Zhang +3 more
openaire +2 more sources
Journal of Biomolecular Structure and Dynamics, 2023
Fanconi anemia (FA) is a genetic disorder that occurs when certain genes responsible for repairing DNA replication and promoting homologous recombination fail to function properly. This leads to severe clinical symptoms and a wide range of cancer-related
Alaa R. Hameed +9 more
semanticscholar +1 more source
Fanconi anemia (FA) is a genetic disorder that occurs when certain genes responsible for repairing DNA replication and promoting homologous recombination fail to function properly. This leads to severe clinical symptoms and a wide range of cancer-related
Alaa R. Hameed +9 more
semanticscholar +1 more source
RANKING DIFFERENTIAL HUBS IN GENE CO-EXPRESSION NETWORKS
Journal of Bioinformatics and Computational Biology, 2012Identifying the genes that change their expressions between two conditions (such as normal versus cancer) is a crucial task that can help in understanding the causes of diseases. Differential networking has emerged as a powerful approach to detect the changes in network structures and to identify the differentially connected genes among two networks ...
Omar Odibat, Chandan K. Reddy
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Journal of Periodontal Research, 2022
BACKGROUND AND OBJECTIVE Periodontitis is an inflammatory disease of the periodontium. However, the hub genes in periodontitis and their correlation with immune cells are not clear.
Xudong Gao +5 more
semanticscholar +1 more source
BACKGROUND AND OBJECTIVE Periodontitis is an inflammatory disease of the periodontium. However, the hub genes in periodontitis and their correlation with immune cells are not clear.
Xudong Gao +5 more
semanticscholar +1 more source
Spatial organization of gene expression: the active chromatin hub
Chromosome Research, 2003Developmental and tissue-specific expression of higher eukaryotic genes involves activation of transcription at the appropriate time and place and keeping it silent otherwise. Unlike housekeeping genes, tissue-specific genes generally do not cluster on the chromosomes.
de Laat, WL (Wouter), Grosveld, Frank
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Biochemical and Biophysical Research Communications - BBRC, 2022
Obesity is a risk factor for cardiovascular disease, leading to ventricular dysfunction and cardiac fibrosis, in which non-cardiomyocytes (nonCMs) play an important role.
Xiaoyu Pan +11 more
semanticscholar +1 more source
Obesity is a risk factor for cardiovascular disease, leading to ventricular dysfunction and cardiac fibrosis, in which non-cardiomyocytes (nonCMs) play an important role.
Xiaoyu Pan +11 more
semanticscholar +1 more source
Identification of hub genes and pathways in cholangiocarcinoma by coexpression analysis
Cancer Biomarkers, 2020BACKGROUND: Cholangiocarcinoma (CCA) is the most common biliary malignancy worldwide. However, the molecular mechanisms of its tumorigenesis and progression are still largely unclear. OBJECTIVE: This study aimed to explore the hub genes and pathways associated with CCA prognosis by coexpression analysis.
Junjie, Kong +3 more
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Identifying Hub Genes Associated with Sex Disparities in Prolactinomas
Genetic Testing and Molecular BiomarkersBackground: Male patients with prolactinomas exhibit greater invasiveness, resistance to dopamine agonists, making treatment more challenging. This study aims to explore the potential different genes contributing to sex disparities in prolactinomas ...
Yuan Zhang +5 more
openaire +2 more sources