Results 61 to 70 of about 389,511 (307)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Anytime Algorithms for Multi-Objective Hub Location Problems [PDF]

, 2018
In many logistic, telecommunications and computer networks, direct routing of commodities between any origin and destination is not viable due to economic and technological constraints.
Chicano, Francisco, Domínguez-Merino, Enrique, Luque-Polo, Gabriel Jesús, Ruiz, Ana B.   +3 more
core  

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

HAVAYOLU KARGO TAŞIMACILIĞINDA KAPASİTE SINIRI OLMAYAN ÇOK ATAMALI p-ANA DAĞITIM ÜSSÜ MEDYAN PROBLEMİNE TAMSAYILI MODEL YAKLAŞIMI

Havacılık ve Uzay Teknolojileri Dergisi, 2009
In the hub and spoke network structure, a facility which has the central location serves as a hub. Flows outgoing from other facilities are collected and grouped in the hub.
Asuman Özger , Hakan Oktal
doaj  

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Scaling of mean first-passage time as efficiency measure of nodes sending information on scale-free Koch networks

, 2011
A lot of previous work showed that the sectional mean first-passage time (SMFPT), i.e., the average of mean first-passage time (MFPT) for random walks to a given hub node (node with maximum degree) averaged over all starting points in scale-free small ...
A. Arenas, A. Baronchelli, A. Kittas, A. Lakhtakia, A.-L. Barabási, A.N. Samukhin, C. Chennubhotla, D.J. Watts, D.S. Callaway, E. Agliari, E. Agliari, E. Bollt, F.C. Santos, F.C. Santos, J.D. Noh, J.D. Noh, L.K. Gallos, M.E.J. Newman, O. Bénichou, O. Bénichou, P. Tetali, R. Albert, R. Metzler, R. Pastor-Satorras, S. Boccaletti, S. Condamin, S. Condamin, S. Havlin, S.N. Dorogovtsev, S.N. Dorogvtsev, Shuyang Gao, V. Sood, Z.Z. Zhang, Z.Z. Zhang, Z.Z. Zhang, Z.Z. Zhang, Z.Z. Zhang, Z.Z. Zhang, Zhongzhi Zhang   +38 more
core   +2 more sources

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Hub Covering Location Problem Considering Queuing and Capacity Constraints [PDF]

Journal of Optimization in Industrial Engineering, 2018
In this paper, a hub covering location problem is considered. Hubs, which are the most congested part of a network, are modeled as M/M/C queuing system and located in placeswhere the entrance flows are more than a predetermined value.A fuzzy constraint ...
Mehdi Seifbarghy, Mojtaba Hemmati, Sepideh Soltan Karimi   +2 more
doaj   +1 more source