Results 111 to 120 of about 137,088 (214)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

One health and human animal-bond intervention strategies- assessing veterinary-social service collaborations. [PDF]

Front Vet Sci
Orchard RJ, Scarbrough E, Crow A, Baldwin M, Moreau C.   +4 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Benefits of the human-animal bond for older veterans and their companion dogs two years after enrolling in a foster-to-adopt program. [PDF]

Explore (NY)
Rekant J, Giffuni J, Addison O, Ortmeyer H.   +3 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Golden Years and Companion Animals: Investigating How the Human-Animal Bond Shapes Pet Wellness in Later Life from the Owner's Perception. [PDF]

Vet Sci
Goma AA, Kieson E.
europepmc   +1 more source

The Dog narratives: Benefits of the human-animal bond for women with HIV. [PDF]

J HIV AIDS Soc Serv, 2015
Kabel A, Khosla N, Teti M.
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Editorial: Human-Animal Interaction (HAI) Research: A Decade of Progress

Frontiers in Veterinary Science, 2020
Sandra McCune, Peggy McCardle, Peggy McCardle, James A. Griffin, Layla Esposito, Karyl Hurley, Regina Bures, Katherine A. Kruger   +7 more
doaj   +1 more source

Exploring the influence of human-animal bonds on suicide characteristics: cross-sectional study of human-animal bond associated suicide in the USA using the National Violent Death Reporting System. [PDF]

BMJ Public Health
Giron A, John R, Martino A, Goodman LF, Yu P, Gholizadeh M, Ramirez MR, Schomberg J.   +7 more
europepmc   +1 more source