Results 111 to 120 of about 136,891 (214)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

One health and human animal-bond intervention strategies- assessing veterinary-social service collaborations. [PDF]

Front Vet Sci
Orchard RJ, Scarbrough E, Crow A, Baldwin M, Moreau C.   +4 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Benefits of the human-animal bond for older veterans and their companion dogs two years after enrolling in a foster-to-adopt program. [PDF]

Explore (NY)
Rekant J, Giffuni J, Addison O, Ortmeyer H.   +3 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Golden Years and Companion Animals: Investigating How the Human-Animal Bond Shapes Pet Wellness in Later Life from the Owner's Perception. [PDF]

Vet Sci
Goma AA, Kieson E.
europepmc   +1 more source

The Dog narratives: Benefits of the human-animal bond for women with HIV. [PDF]

J HIV AIDS Soc Serv, 2015
Kabel A, Khosla N, Teti M.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Editorial: Human-Animal Interaction (HAI) Research: A Decade of Progress

Frontiers in Veterinary Science, 2020
Sandra McCune, Peggy McCardle, Peggy McCardle, James A. Griffin, Layla Esposito, Karyl Hurley, Regina Bures, Katherine A. Kruger   +7 more
doaj   +1 more source

Exploring the influence of human-animal bonds on suicide characteristics: cross-sectional study of human-animal bond associated suicide in the USA using the National Violent Death Reporting System. [PDF]

BMJ Public Health
Giron A, John R, Martino A, Goodman LF, Yu P, Gholizadeh M, Ramirez MR, Schomberg J.   +7 more
europepmc   +1 more source