Results 61 to 70 of about 884,920 (217)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Epidemiology of BVD and persistently infected cattle across urban and peri-urban dairy farms in central, northern, and southern parts of Ethiopia

BMC Veterinary Research
Background Bovine viral diarrhea (BVD) is an economically significant disease affecting both domestic and wild ruminant species. The causative agent is bovine viral diarrhea virus (BVDV) of the genus Pestivirus within the family Flaviviridae. In Ethiopia,
Asamenew Tesfaye Melkamsew, Tesfaye Sisay Tessema, Abebe Garoma, Jan Paeshuyse   +3 more
doaj   +1 more source

A pilot randomized controlled trial to examine the impact of a therapy dog intervention on loneliness in adult patients hospitalized in a psychiatric unit

Frontiers in Psychiatry
Background and objectivesLoneliness has been linked to a number of health threats and is associated with significant morbidity and mortality risks among people with mental illness.
Nancy R. Gee, Lisa Townsend, Erika Friedmann, Sandra B. Barker, Tushar P. Thakre, Megan K. Mueller   +5 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Host Immune Response to Bovine Viral Diarrhea Virus (BVDV): Insights and Strategies for Effective Vaccine Design

Vaccines
Bovine viral diarrhea (BVD) is caused by bovine viral diarrhea virus (BVDV), a member of the genus Pestivirus and in the family Flaviviridae. According to some studies, the disease incurs USD 1.5–2.5 billion per year and USD 0.50 to USD 687.80 per cow ...
Asamenew Tesfaye Melkamsew, Tesfaye Sisay Tessema, Jan Paeshuyse   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Exploring adolescents’ attitudes and animal ethics orientations in a socio-scientific issues context: insights from a study on animal experimentation

Discover Education
Teaching socio-scientific issues (SSI) fosters students' ethical reasoning, yet many educators struggle with integrating these topics into science classrooms. This exploratory mixed-methods study investigates how ethical reflection influences adolescents'
Sonja Michaela Enzinger-Mühlbacher, Christian Dürnberger   +1 more
doaj   +1 more source

Mixed-reality-based human-animal interaction can relieve mental stress. [PDF]

Front Vet Sci, 2023
Na H, Dong SY.
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source