Results 51 to 60 of about 167,815 (294)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Observation of human-animal interaction for research (OHAIRE) behavior coding in a randomized control trial of children with attention-deficit hyperactivity disorder (ADHD) and a canine-assisted intervention

Frontiers in Psychiatry
IntroductionDiagnosed in about 10% of children in the United States, attention-deficit hyperactivity disorder (ADHD) is characterized by symptoms including inattention, hyperactivity, and impulsivity.
Leanne O. Nieforth, Noémie A. Guerin, Annamarie Stehli, Sabrina E. B. Schuck, Katherine Yi, Marguerite E. O’Haire   +5 more
doaj   +1 more source

Dogs Supporting Human Health and Well-Being: A Biopsychosocial Approach

Frontiers in Veterinary Science, 2021
Humans have long realized that dogs can be helpful, in a number of ways, to achieving important goals. This is evident from our earliest interactions involving the shared goal of avoiding predators and acquiring food, to our more recent inclusion of dogs
Nancy R. Gee, Kerri E. Rodriguez, Aubrey H. Fine, Janet P. Trammell   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Australian animal painting and the human-animal bond in art [PDF]

, 2014
Animal painting is a critically important part of Australian art history, yet it has been afforded scant–if any–scholarly attention. Additionally, as the genre reached an apotheosis in the nineteenth century, animal painting represents a window into ...
Kovacic, Katherine Vanessa
core  

WSAVA animal welfare survey: information sources used by companion animal veterinarians [PDF]

, 2021
Introduction: Veterinarians are expected to have expertise not only in the maintenance of health and the treatment and prevention of disease in animals, but also in matters relating to animal welfare.
van Lith, Hein, Endenburg, Nienke
core  

Is There a Correlation Between Dog Obesity and Human Obesity? Preliminary Findings of Overweight Status Among Dog Owners and Their Dogs

Frontiers in Veterinary Science, 2021
Background and Aim: Obesity is a serious health issue in people and their pets, with a need for innovative and engaging prevention strategies. One possible strategy is a One Health approach incorporating dogs into prevention programs; however, little ...
Deborah E. Linder, Deborah E. Linder, Sasha Santiago, Eli D. Halbreich   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Human-human and human-animal interaction [PDF]

, 2010
The aim of the present thesis was to investigate hormonal and physiological effects in mothers during a breastfeeding session and in dogs and their owners in response to short-term interaction.
Handlin, Linda
core