Aligning Pathology Assessment in a Learner-Centered Undergraduate Medical Curriculum [PDF]
, 2017 Introduction: The Bond Medical Program delivers pathology in the preclinical years through interactive learning. Assessment for learning demands fit-for-purpose assessment that aligns with the curriculum.
Doshi, Neelam +2 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Measurement of attachment in human-animal interaction research
Human-Animal InteractionsResearchers in the field of human-animal interaction often investigate the construct of the human-animal bond in order to measure contextual information about companion-animal relationships beyond simply living with a pet.
Eli D. Halbreich +3 more
doaj +1 more source
An Exploration of Attitudes toward Dogs among College Students in Bangalore, India [PDF]
, 2019 Conversations in the field of anthrozoology include treatment and distinction of food animals, animals as workers versus pests, and most recently, emerging pet trends including the practice of pet parenting.
Gray, Peter B. +3 more
core +3 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Veterinary Medicine and Science, 2019 Previous studies in human medicine have found that patients prefer their doctors to be more formally attired, and that this influences their trust and confidence in their physician.
Kathryn A. Robb +6 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
A Bright Future for Human-Animal Interaction Research
Human-Animal Interactions, 2023 Steven Feldman
doaj +1 more source
Structure-activity relationships based on 3D-QSAR CoMFA/CoMSIA and design of aryloxypropanol-amine agonists with selectivity for the human β3-adrenergic receptor and anti-obesity and anti-diabetic profiles [PDF]
, 2018 Indexación: Scopus.Acknowledgments: This work was supported by FONDECYT No. 11130701. We would also like to thank fDoTr CthLeafbr efeora vthaeil afrbeilei tayvoafiltahbeilsitoyf towfa trheer seoqfutwireadret orecqaulciureladt etothcealAcuDla(thet ttph:e/
Andrades-Lagos, J. +7 more
core +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source