Results 171 to 180 of about 1,230,539 (304)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A Re-examination of Epistemological Paradigms Describing Animal Behavior in 8 Points. ‘Animal Consciousness and Science Matter’: a Reply

Relations, 2013
Roberto Marchesini
doaj   +1 more source

Exploring the Role of Cognitive Reserve and Human-Animal Interaction in Late-Life Depression: A Moderation Analysis. [PDF]

Geriatrics (Basel)
de Albuquerque NS, Sessegolo NS, Moret-Tatay C, Irigaray TQ.   +3 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Zoonotic Transmission of Soil-Transmitted Helminths in a Setting with Close Human-Animal Interaction: A Cross-Sectional Pilot Study from Meghalaya, India. [PDF]

Am J Trop Med Hyg
Mawrie UG, Manuel M, Marbaniang PJ, Sangriang IL, Laxmanan S, Ajjampur SSR, Sarkar R.   +6 more
europepmc   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Editorial: Evidencing the impact of human-animal interaction for those living with mental health problems. [PDF]

Front Psychiatry
Shoesmith E, Hawkins RD, Ratschen E.
europepmc   +1 more source

Human-Animal Welfare: The interconnectedness of human well-being and animal welfare [PDF]

One Welfare is a concept that promotes the interconnection between human well-being, animal welfare and environmental sustainability. Therefore, the welfare of one influences the welfare of the others, and vice versa. Based on this approach, this chapter
Justine Cole (14211761), Laetitia Marechal (17162764), Meagan King (13187146), Ana Maria Barcelos Guerra Pinto (17171113)   +3 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Effects of human-animal interaction on salivary and urinary oxytocin in children and dogs. [PDF]

Psychoneuroendocrinology
Gnanadesikan GE, King KM, Carranza E, Flyer AC, Ossello G, Smith PG, Steklis NG, Steklis HD, Carter CS, Connelly JJ, Barnett M, Gee N, Tecot SR, MacLean EL.   +13 more
europepmc   +1 more source