Results 71 to 80 of about 2,814,535 (299)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Multiple telecouplings and their complex interrelationships
Ecology and Society, 2015 Increasingly, the world is becoming socioeconomically and environmentally connected, but many studies have focused on human-environment interactions within a particular area. Although some studies have considered the impacts of external factors, there is
Jianguo Liu +15 more
doaj +1 more source
Human-Smart Environment Interactions in Smart Cities: Exploring Dimensionalities of Smartness
Future Internet, 2020 In the context of the challenges facing human computer interaction (HCI) on the one hand and the future Internet on the other, the purpose of this study is to explore the multi-dimensionality of smart cities, looking at relationships and ...
H. Patricia McKenna
doaj +1 more source
Smart Geographic object: Toward a new understanding of GIS Technology in Ubiquitous Computing [PDF]
, 2015 One of the fundamental aspects of ubiquitous computing is the instrumentation of the real world by smart devices. This instrumentation constitutes an opportunity to rethink the interactions between human beings and their environment on the one hand, and ...
Abdelaziz, El Fazziki +5 more
core +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The cultural epigenetics of psychopathology: The missing heritability of complex diseases found? [PDF]
, 2009 We extend a cognitive paradigm for gene expression based on the asymptotic limit theorems of information theory to the epigenetic epidemiology of mental disorders.
Wallace, Rodrick
core +1 more source
Incorporating a mucosal environment in a dynamic gut model results in a more representative colonization by lactobacilli [PDF]
, 2011 To avoid detrimental interactions with intestinal microbes, the human epithelium is covered with a protective mucus layer that traps host defence molecules. Microbial properties such as adhesion to mucus further result in a unique mucosal microbiota with
Derde, Melanie +10 more
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Situational Enterprise Services [PDF]
, 2010 The ability to rapidly find potential business partners as well as rapidly set up a collaborative business process is desirable in the face of market turbulence.
de Vrieze, Paul Ton, Xie, Li, Xu, Lai
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source