Results 1 to 10 of about 18,969 (70)
Pharmacological Research, 2023 As depression is projected to become the leading mental disease burden globally by 2030, understanding the underlying pathology, as well as screening potential anti-depressants with a higher efficacy, faster onset of action, and/or fewer side-effects is ...
Christiane Brandwein +10 more
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Frontiers in Behavioral Neuroscience, 2022 The use of animals in neurosciences is pivotal to gaining insights into complex functions and dysfunctions of behavior. For example, various forms of physical and/or psychological stress are inherent to various animal models for psychiatric disorders, e ...
Anne Stephanie Mallien +8 more
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Brain Sciences, 2023 Background: The Italian National Institute of Health (Istituto Superiore di Sanità) funded a 30-month project (July 2021–January 2024) to conduct a twin study of the relationships between Positive Mental Health (PMH) and cellular longevity.
Francesca Marcon +11 more
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Frontiers in Psychiatry, 2021 Extensive evidence suggests a dysfunction of the glutamate NMDA receptor (NMDAR) in schizophrenia, a severe psychiatric disorder with putative early neurodevelopmental origins, but clinical onset mainly during late adolescence.
Anne S. Mallien +8 more
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Theoretical foundations of structural components and determinants of cadets’ role interaction: Metasystem approach [PDF]
Известия Саратовского университета. Новая серия: Акмеология образования. Психология развития, 2021 The relevance of the study is conditioned by changes taking place in the Russian Armed Forces, which are associated with the growth of military conflicts, with reforms and reorganizations in the structure of the National Guard, etc. Therefore, it imposes
Nurzhan S. Mekebaev +1 more
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Frontiers in Behavioral Neuroscience, 2022 In preclinical psychiatry research, animals are central to modeling and understanding biological mechanisms of behavior and psychiatric disorders. We here present the first multimodal severity assessment of a genetically modified rat strain used in ...
Anne Stephanie Mallien +15 more
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Genome wide association study identifies four loci for early onset schizophrenia
Translational Psychiatry, 2021 Early onset schizophrenia (EOS, defined as first onset of schizophrenia before age 18) is a rare form of schizophrenia (SCZ). Though genome-wide association studies (GWASs) have identified multiple risk variants for SCZ, most of the cases included in ...
Suqin Guo +8 more
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BMC Medicine, 2021 Background Over 200 schizophrenia risk loci have been identified by genome-wide association studies (GWASs). However, the majority of risk loci were identified in populations of European ancestry (EUR), potentially missing important biological insights ...
Jiewei Liu +11 more
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Bidirectional genetic overlap between bipolar disorder and intelligence
BMC Medicine, 2022 Background Bipolar disorder (BD) is a highly heritable psychiatric illness exhibiting substantial correlation with intelligence. Methods To investigate the shared genetic signatures between BD and intelligence, we utilized the summary statistics from ...
Meng-Yuan Shang +8 more
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Transcriptome-wide association study identifies new susceptibility genes and pathways for depression
Translational Psychiatry, 2021 Depression is the most prevalent mental disorder with substantial morbidity and mortality. Although genome-wide association studies (GWASs) have identified multiple risk variants for depression, due to the complicated gene regulatory mechanisms and ...
Xiaoyan Li +7 more
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