Results 31 to 40 of about 756,694 (263)

Shared genetic architecture and causal relationship between sleep behaviors and lifespan

Translational Psychiatry
Poor sleep health is associated with a wide array of increased risk for cardiovascular, metabolic and mental health problems as well as all-cause mortality in observational studies, suggesting potential links between sleep health and lifespan.
Yong Wu, Chu-Yi Zhang, Xiaolan Liu, Lu Wang, Ming Li, Yi Li, Xiao Xiao   +6 more
doaj   +1 more source

What does the public think about microplastics? Insights from an empirical analysis of mental models elicited through free associations

Frontiers in Psychology, 2022
Microplastics are an issue of rising concern, in terms of their possible implications for both the environment and human health. A survey was distributed among a representative sample of the adult Norwegian population (N = 2720) to explore the public ...
Marcos Felipe-Rodriguez, Gisela Böhm, Gisela Böhm, Rouven Doran   +3 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

A Psychological Model of Mental Disorder [PDF]

Harvard Review of Psychiatry, 2005
A coherent conceptualization of the role of psychological factors is of great importance in understanding mental disorder. Academic articles and professional reports alluding to psychological models of the etiology of mental disorder are becoming increasingly common, and there is evidence of a marked policy shift toward the provision of psychological ...
openaire   +3 more sources

Identification of 1q25.2 as a novel shared locus between schizophrenia and major depressive disorder in east Asians by integrative analyses

Translational Psychiatry
Schizophrenia (SZ) and major depressive disorder (MDD) share psychopathological features, and their overlapped genetic architectures have been well-studied in Europeans.
Xiaoge Guo, Jinhua Huo, Peiling Shi, Luwen Zhang, Chuyi Zhang, Yongfeng Yang, Ming Li, Luxian Lv, Xiao Xiao, Wenqiang Li, Chuansheng Wang   +10 more
doaj   +1 more source

Mental models and creative thinking skills in students’ physics learning

Creativity Studies, 2023
The study of mental models and creative thinking skills in students’ physics learning with the problem-based learning model has been scarce. This study aimed to analyze the relationship between mental models and creative thinking skills in high school ...
John Rafafy Batlolona, Markus Diantoro
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

A formação em Química discutida com base nos modelos proposto por estudantes de pós-graduação para o fenômeno de dissolução Graduation in chemistry discussed in relation to graduate students' models concerning the phenomenon of dissolution

Química Nova, 2009
Mental models play an important role in the evolution of an individual's so-called knowledge. Using such representations, students can explain, foresee, and attribute causality to observed phenomena. In the case of Chemistry, the ability to work mentally
Karina Aparecida de Freitas Dias de Souza, Arnaldo Alves Cardoso   +1 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source