Results 51 to 60 of about 109,968,647 (310)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Human in the Loop Novelty Generation

CoRR, 2023
Developing artificial intelligence approaches to overcome novel, unexpected circumstances is a difficult, unsolved problem. One challenge to advancing the state of the art in novelty accommodation is the availability of testing frameworks for evaluating performance against novel situations.
Mark Bercasio, Allison Wong, Dustin Dannenhauer   +2 more
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The accessory subunit of mitochondrial DNA polymerase {gamma} determines the DNA content of mitochondrial nucleoids in human cultured cells [PDF]

, 2009
The accessory subunit of mitochondrial DNA polymerase γ, POLGβ, functions as a processivity factor in vitro. Here we show POLGβ has additional roles in mitochondrial DNA metabolism.
H. Sembongi, T. Yasukawa, Yasukawa, T, Di Re, M., I. J. Holt, L. J. Bailey, Fersht, A.R., Boyd-Kirkup, JD, Martinsson, P., Holt, I.J., J. N. Spelbrink, Sembongi, H, Spelbrink, JN, Bailey, LJ, Sembongi, H., Goffart, S, P. Martinsson, A. R. Fersht, Di Re, M, Martinsson, P, Reyes, A., J. D. Boyd-kirkup, S. Goffart, Bailey, L.J., Fersht, AR, Wong, TS, T. S. Wong, Reyes, A, M. Di Re, Holt, IJ, J. He, He, J., Goffart, S., A. Reyes, Boyd-Kirkup, J.D., Wong, T.S., He, J, Yasukawa, T., Spelbrink, J.N.   +38 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Using detergent to enhance detection sensitivity of African trypanosomes in human CSF and blood by Loop-Mediated Isothermal Amplification (LAMP) [PDF]

, 2011
<p><b>Background:</b> The loop-mediated isothermal amplification (LAMP) assay, with its advantages of simplicity, rapidity and cost effectiveness, has evolved as one of the most sensitive and specific methods for the detection of a ...
Gibson, W., Thekisoe, Oriel M M, Dumler, JS, Olga V. Nikolskaia, Olga V Nikolskaia, Liam J Morrison, Inoue, N., Noboru Inoue, Liam J. Morrison, Dennis J Grab, Oriel M. M. Thekisoe, Dumler J. Stephen, Grab, DJ, J. Stephen Dumler, Dumler, J.S., J Stephen Dumler, Morrison, L.J., Nikolskaia Olga V., Dumler, J Stephen, Nikolskaia, O.V., Nikolskaia, OV, Grab, D.J., Grab, Dennis J, Wendy Gibson, Morrison Liam J., Grab Dennis J., Inoue, N, Gibson, WC, Thekisoe, Oriel M. M., Oriel M M Thekisoe, Inoue, Noboru, Thekisoe Oriel M. M., Morrison, Liam J; id_orcid, Gibson Wendy, Thekisoe, OMM, Morrison, L, Inoue Noboru, Dennis J. Grab, Nikolskaia, Olga V, Gibson, Wendy   +39 more
core   +1 more source

Baseline dependent differences in the perception of changes in visuomotor delay

Frontiers in Human Neuroscience
IntroductionThe detection of, and adaptation to delayed visual movement feedback has been extensively studied. One important open question is whether the Weber-Fechner Laws hold in the domain of visuomotor delay; i.e., whether the perception of changes ...
Gesche Vigh, Gesche Vigh, Jakub Limanowski, Jakub Limanowski   +3 more
doaj   +1 more source

Study on Human-Machine Hybrid Intelligent Decision-making Paradigm and Its Operational Application [PDF]

Jisuanji kexue
Human-machine hybrid intelligence combines machine intelligence and human intelligence,giving full play to the respective intelligence advantages of machines and humans,and realizing cross-vector and cross-cognition of intelligence.As a new form of ...
DING Yanyan, FENG Jianhang, YE Ling, ZHENG Shaoqiu, LIU Fan
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source