Results 51 to 60 of about 151,009,840 (300)

A kinematic dataset of locomotion with gait and sit-to-stand movements of young adults

Scientific Data
Kinematic data is a valuable source of movement information that provides insights into the health status, mental state, and motor skills of individuals.
Simon Hanisch, Loreen Pogrzeba, Evelyn Muschter, Shu-Chen Li, Thorsten Strufe   +4 more
doaj   +1 more source

Human-In-The-Loop Automatic Program Repair [PDF]

2020 IEEE 13th International Conference on Software Testing, Validation and Verification (ICST), 2020
Accepted as full paper (10+2 pages) at ICST'20 (https://icst2020.info/) *** Tool and Replication Package at: https://github.com/mboehme ...
Charaka Geethal, Marcel Böhme, Van-Thuan Pham   +2 more
openaire   +4 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Human in the Loop Novelty Generation

CoRR, 2023
Developing artificial intelligence approaches to overcome novel, unexpected circumstances is a difficult, unsolved problem. One challenge to advancing the state of the art in novelty accommodation is the availability of testing frameworks for evaluating performance against novel situations.
Mark Bercasio, Allison Wong, Dustin Dannenhauer   +2 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The accessory subunit of mitochondrial DNA polymerase {gamma} determines the DNA content of mitochondrial nucleoids in human cultured cells [PDF]

, 2009
The accessory subunit of mitochondrial DNA polymerase γ, POLGβ, functions as a processivity factor in vitro. Here we show POLGβ has additional roles in mitochondrial DNA metabolism.
H. Sembongi, T. Yasukawa, Yasukawa, T, Di Re, M., I. J. Holt, L. J. Bailey, Fersht, A.R., Boyd-Kirkup, JD, Martinsson, P., Holt, I.J., J. N. Spelbrink, Sembongi, H, Spelbrink, JN, Bailey, LJ, Sembongi, H., Goffart, S, P. Martinsson, A. R. Fersht, Di Re, M, Martinsson, P, Reyes, A., J. D. Boyd-kirkup, S. Goffart, Bailey, L.J., Fersht, AR, Wong, TS, T. S. Wong, Reyes, A, M. Di Re, Holt, IJ, J. He, He, J., Goffart, S., A. Reyes, Boyd-Kirkup, J.D., Wong, T.S., He, J, Yasukawa, T., Spelbrink, J.N.   +38 more
core   +2 more sources

Observing positive and negative social touch triggers topographically distinct physical and emotional reactions in the body

Scientific Reports
Interpersonal touch is a fundamentally multidimensional and multisensory experience and as such is highly subjective. By whom, where and how we are touched determines how we react to and feel about it. Previous research using topographical body tasks has
Justyna Świdrak, Wenhan Sun, Pinar Ekin, Merle T. Fairhurst   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Human-in-the-Loop co-Design [PDF]

This study aims to enhance understanding of the performance of human-learning HITL approaches in human-AI co-design processes. The conversation mode of human-learning HITL in human-AI co-design processes and usage patterns performance in AI-learning HITL
Haoyu Zuo (20609843), Peter Childs (1568911), Pingfei Jiang (22169326), Liuqing Chen (295025), Pan Wang (198097), Yuan Yin (2004361), Ji Han (21068693), Kamyar Hazeri (24384819)   +7 more
core   +6 more sources