Results 61 to 70 of about 109,968,647 (310)

Human-in-the-Loop Optimization of Transcranial Electrical Stimulation at the Point of Care: A Computational Perspective

, 2022
Individual differences in the responsiveness of the brain to transcranial electrical stimulation (tES) are increasingly demonstrated by the large variability in the effects of tES.
Yashika Arora (11529693), Anirban Dutta (17171794)   +1 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Sophie Doulut, "The Ivory Horse"

, 2023
One day I rode a magnificent ivory horse It took me up high into the sky Galloping as fast as it could, Bolting from one cloud to the other, And I finally landed Onto another soil, A foreign kingdom Where strange people Spoke a ...
The LOOP team
core  

Impact of laparoscopic training, haptic feedback and visual haptic latency on virtual fine motor performance

Scientific Reports
Advancements in minimally invasive surgery, including haptic feedback and telesurgery systems, offer potential benefits for surgical education and patient outcomes.
Denise Tzolov, Jean-Paul Bereuter, Mark Enrik Geissler, Rona Berit Geissler, Grit Krause-Jüttler, Jürgen Weitz, Marius Distler, Florian Oehme, Annika Dix, Felix von Bechtolsheim   +9 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Adam Wyeth: a patron of LOOP

Loop is delighted and honoured to announce that poet and playwright Adam Wyeth, who lives and works in Dublin, is as of June 2024 a patron of Loop. We look forward to continuing our conversation with Adam, begun at the excellent 2024 SAES Congress at ...
The LOOP team
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Human-in-the-Loop Interpretability Prior

Advances in neural information processing systems, 2018
To appear at NIPS 2018, selected for a spotlight. 13 pages (incl references and appendix)
Isaac Lage, Andrew Slavin Ross, Been Kim, Samuel J. Gershman, Finale Doshi-Velez   +4 more
openaire   +4 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Jump assessment on a force plate—an approach to quantify subtle lower limb neuromuscular deficits in people with multiple sclerosis

Frontiers in Neurology
Neuromuscular impairments are common in people with multiple sclerosis (pwMS), often beginning subclinically in early disease stages and contributing to long-term disability. Traditional clinical tools such as the Expanded Disability Status Scale (EDSS),
Anne Geßner, Maximilian Hartmann, Heidi Stölzer-Hutsch, Katrin Trentzsch, Tjalf Ziemssen   +4 more
doaj   +1 more source