Results 61 to 70 of about 151,009,840 (300)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Baseline dependent differences in the perception of changes in visuomotor delay
Frontiers in Human NeuroscienceIntroductionThe detection of, and adaptation to delayed visual movement feedback has been extensively studied. One important open question is whether the Weber-Fechner Laws hold in the domain of visuomotor delay; i.e., whether the perception of changes ...
Gesche Vigh +3 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Sophie Doulut, "The Ivory Horse"
, 2023 One day I rode a magnificent ivory horse It took me up high into the sky Galloping as fast as it could, Bolting from one cloud to the other, And I finally landed Onto another soil, A foreign kingdom Where strange people Spoke a ...
The LOOP team
core
Study on Human-Machine Hybrid Intelligent Decision-making Paradigm and Its Operational Application [PDF]
Jisuanji kexueHuman-machine hybrid intelligence combines machine intelligence and human intelligence,giving full play to the respective intelligence advantages of machines and humans,and realizing cross-vector and cross-cognition of intelligence.As a new form of ...
DING Yanyan, FENG Jianhang, YE Ling, ZHENG Shaoqiu, LIU Fan
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Loop is delighted and honoured to announce that poet and playwright Adam Wyeth, who lives and works in Dublin, is as of June 2024 a patron of Loop. We look forward to continuing our conversation with Adam, begun at the excellent 2024 SAES Congress at ...
The LOOP team
core +1 more source
Scientific ReportsAdvancements in minimally invasive surgery, including haptic feedback and telesurgery systems, offer potential benefits for surgical education and patient outcomes.
Denise Tzolov +9 more
doaj +1 more source
Human-in-the-Loop Interpretability Prior
Advances in neural information processing systems, 2018 To appear at NIPS 2018, selected for a spotlight. 13 pages (incl references and appendix)
Isaac Lage +4 more
openaire +5 more sources
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source