Results 171 to 180 of about 19,334 (259)

Computational evaluation of carnosic acid as a 4EY7 inhibitor for potential anti-Alzheimer therapy. [PDF]

Front Aging Neurosci
Alhamyani A.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Integrated Computational Profiling Links Position-specific O-Methylation to Spontaneous Complexation and Improved Binding in Flavonoid-HER2 Systems. [PDF]

Bioinform Biol Insights
Akinnusi PA, Olubode SO, Okai DNA, Akinbami OI, Oyerinde DO, Akinnusi AJ.   +5 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacokinetics and Toxicity Overview of Active Compounds Berberine, Palmatine, and Jatrorrhizine From <i>Fibraurea tinctoria</i> Lour: Drug-Likeness, ADMET Prediction, and In Vivo Extract Toxicity Assessment. [PDF]

J Toxicol
Purwaningsih I, Maksum IP, Sumiarsa D, Sriwidodo S.   +3 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Spathulenol, a Sesquiterpene from <i>Guarea macrophylla</i>, Displays Potent and Selective <i>Anthelmintic</i> Activity against <i>Angiostrongylus cantonensis</i>. [PDF]

ACS Omega
Santos JM, Fukui-Silva L, Amorim CS, Gonçalves MM, Moriconi JPV, Alborghetti IS, de Almeida RBP, Lago JHG, de Moraes J.   +8 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Recent Developments in Ferulic Acid- and Caffeic Acid-Based Hybrids with Potential Anticancer Properties. [PDF]

Molecules
Peter S, Sibali LL, Khwaza V, Paca AM.
europepmc   +1 more source

Perceptual and category processing of the Uncanny Valley hypothesis' dimension of human likeness: some methodological issues. [PDF]

J Vis Exp, 2013
Cheetham M, Jancke L.
europepmc   +1 more source