Results 71 to 80 of about 8,960,514 (293)

Human-like robotic handwriting and drawing

2013 IEEE International Conference on Robotics and Automation, 2013
The method of human-like handwriting and drawing is addressed with a three-link arm. Three strategies of trajectory planning are considered: the basic stroke method, the Bezier curve method, and the non-gradient numerical optimization method. Planar patterns of handwriting or drawing are converted into the vector form of joint angles in which sequence ...
Boren Li, Yuan F. Zheng, Hooshang Hemami, Da Che   +3 more
openaire   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

How Visual and Mental Human-Likeness of Virtual Influencers Affects Customer–Brand Relationship on E-Commerce Platform

Journal of Theoretical and Applied Electronic Commerce Research
Virtual influencers (VIs) on e-commerce platforms are becoming increasingly popular, enhancing the consumer experience. This study examines the consumer–brand relationship (CBR) with VIs through the perspective of social presence.
Liangbo Zhang, Linlin Mo, Xiaohui Sun, Zhimin Zhou, Jifan Ren   +4 more
doaj   +1 more source

Effect of Phosphorylation on a Human-like Osteopontin Peptide [PDF]

Biophysical Journal, 2017
The last decade established that the dynamic properties of the phosphoproteome are central to function and its modulation. The temporal dimension of phosphorylation effects remains nonetheless poorly understood, particularly for intrinsically disordered proteins.
Lenton, Samuel, Grimaldo, Marco, Roosen-Runge, Felix, Schreiber, Frank, Nylander, Tommy, Clegg, Roger, Holt, Carl, Hartlein, Michael, Sakai, Victoria Garcia, Seydel, Tilo, Teixeira, Susana C. Marujo   +10 more
openaire   +5 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Stimulus-category competition, inhibition and affective devaluation: A novel account of the Uncanny Valley

Frontiers in Psychology, 2015
Stimuli that resemble humans, but are not perfectly human-like, are disliked compared to distinctly human and nonhuman stimuli. Accounts of this Uncanny Valley effect often focus on how changes in human resemblance can evoke different emotional responses.
Anne E. Ferrey, Tyler J. Burleigh, Mark J. Fenske   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Industrial Robot Movements, Human-Likeness & Preference

In order to understand how specific movements of industrial robots lead to perception of human likeness and preferences, we conducted an online experiment with 100 participants, recruited using Prolific.
Hostettler, Damian
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source